Herpesviridae Lymphocryptovirus

The Herpesviridae are a large family of enveloped DNA viruses that cause disease in several animal species, including humans. Herpesviruses have large double-stranded linear DNA genomes of 120-220kb encoding 100-200 genes. The Herpesviridae family can be subdivided into alpha, beta and gamma herpesviridae.

Lymphocryptoviruses are a subdivision of the gamma herpesviruses. This family includes human herpesvirus 4 (HHV-4, also known as Epstein-Barr virus, EBV) as the type species, as well as viruses that infect other primate species. These viruses predominantly infect B-lymphocytes and can be oncogenic. In humans HHV-4 is ubiquitous and is associated with infectious mononucleosis, the B-cell tumour Burkitt’s lymphoma and the epithelial tumour nasopharyngeal carcinoma (NPC).

Data Downloads

This project is ongoing and data for this organism will be made available in due course.

Human herpesvirus 4 (HHV-4 or Epstein Barr virus, EBV) is an oncogenic herpesvirus that causes infectious mononucleosis and is associated with tumours including nasopharyngeal carcinoma and Burkitt’s lymphoma. We are currently sequencing the full genome of HHV-4 present in human saliva using both Roche 454 and Illumina sequencing technology. We also aim to determine the full genome sequence from both virus present in Burkitt's lymphoma and nasopharyngeal carcinoma.

Published Genome Data

NC_007605 Human herpesvirus 4 type 1, complete genome can be found here

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk