Herpesviridae Lymphocryptovirus

The Herpesviridae are a large family of enveloped DNA viruses that cause disease in several animal species, including humans. Herpesviruses have large double-stranded linear DNA genomes of 120-220kb encoding 100-200 genes. The Herpesviridae family can be subdivided into alpha, beta and gamma herpesviridae.

Lymphocryptoviruses are a subdivision of the gamma herpesviruses. This family includes human herpesvirus 4 (HHV-4, also known as Epstein-Barr virus, EBV) as the type species, as well as viruses that infect other primate species. These viruses predominantly infect B-lymphocytes and can be oncogenic. In humans HHV-4 is ubiquitous and is associated with infectious mononucleosis, the B-cell tumour Burkitt’s lymphoma and the epithelial tumour nasopharyngeal carcinoma (NPC).

Data Downloads

This project is ongoing and data for this organism will be made available in due course.

[Genome Research Limited]

Human herpesvirus 4 (HHV-4 or Epstein Barr virus, EBV) is an oncogenic herpesvirus that causes infectious mononucleosis and is associated with tumours including nasopharyngeal carcinoma and Burkitt’s lymphoma. We are currently sequencing the full genome of HHV-4 present in human saliva using both Roche 454 and Illumina sequencing technology. We also aim to determine the full genome sequence from both virus present in Burkitt's lymphoma and nasopharyngeal carcinoma.

Published Genome Data

NC_007605 Human herpesvirus 4 type 1, complete genome can be found here

Studies

Herpesvirus whole genome sequencing

Sample

Strain

Run Accession

1210_JSC1_SN_EBUnknownERR244000
1210_JSC1_SN_EBUnknownERR244018
1215_HBL6_SN_EBUnknownERR244001
1215_HBL6_SN_EBUnknownERR244019
1204_Akata_SN_EBUnknownERR244002
1204_Akata_SN_EBUnknownERR244020
1207_Daudi_SN_EBUnknownERR244003
1207_Daudi_SN_EBUnknownERR244021
1403_JSC1_EBUnknownERR244009
1403_JSC1_EBUnknownERR244027
1402_HBL6_EBUnknownERR244010
1402_HBL6_EBUnknownERR244028
1401_BC1_EBUnknownERR244011
1401_BC1_EBUnknownERR244029
1438_saliva8_EBUnknownERR244012
1438_saliva8_EBUnknownERR244030
1440_saliva6_EBUnknownERR244013
1440_saliva6_EBUnknownERR244031
1441_saliva9_EBUnknownERR244014
1441_saliva9_EBUnknownERR244032
123_saliva4_EBUnknownERR244015
123_saliva4_EBUnknownERR244033
2022_1-1_EUnknownERR244037
2023_1-2_EUnknownERR244038
2024_1-3_EUnknownERR244039
2025_1-4_EUnknownERR244040
2026_2-1_EUnknownERR244067
2027_2-2_EUnknownERR244068
2028_2-3_EUnknownERR244043
2029_3-1_EUnknownERR244044
2030_3-2_EUnknownERR244045
2031_3-3_EUnknownERR244046
2033_4-1_EUnknownERR244048
2032_3-4_EUnknownERR244054
2034_4_2_EUnknownERR244065
2035_4_3_EUnknownERR244066
425STDY5139010UnknownERR244074
425STDY5139011UnknownERR244075
425STDY5139012UnknownERR244076
425STDY5139013UnknownERR244077
425STDY5139014UnknownERR244123
425STDY5139014UnknownERR244117
425STDY5139015UnknownERR244118
425STDY5139015UnknownERR244124
425STDY5139017UnknownERR244078
425STDY5139018UnknownERR244079
425STDY5139023UnknownERR244080
425STDY5139024UnknownERR244081
425STDY5139025UnknownERR244082
425STDY5139026UnknownERR244083
425STDY5139027UnknownERR244084
425STDY5139028UnknownERR244085
425STDY5139029UnknownERR244086
425STDY5139030UnknownERR244087
425STDY5139031UnknownERR244088
425STDY5139032UnknownERR244089
425STDY5139033UnknownERR244125
425STDY5139033UnknownERR244119
425STDY5139034UnknownERR244106
425STDY5139034UnknownERR244126
425STDY5139035UnknownERR244107
425STDY5139035UnknownERR244127
425STDY5139036UnknownERR244108
425STDY5139036UnknownERR244128
425STDY5139037UnknownERR244109
425STDY5139037UnknownERR244129
425STDY5139038UnknownERR244110
425STDY5139038UnknownERR244130
425STDY5139039UnknownERR244090
425STDY5139040UnknownERR244091
425STDY5139041UnknownERR244092
425STDY5139042UnknownERR244093
425STDY5139043UnknownERR244094
425STDY5139044UnknownERR244095
425STDY5139045UnknownERR244096
425STDY5139046UnknownERR244097
425STDY5139047UnknownERR244131
425STDY5139047UnknownERR244111
425STDY5139048UnknownERR244112
425STDY5139048UnknownERR244132
425STDY5139049UnknownERR244133
425STDY5139049UnknownERR244113
425STDY5139050UnknownERR244114
425STDY5139050UnknownERR244120
425STDY5139051UnknownERR244098
425STDY5139052UnknownERR244099
425STDY5139053UnknownERR244100
425STDY5139054UnknownERR244101
425STDY5139055UnknownERR244102
425STDY5139056UnknownERR244103
425STDY5139057UnknownERR244104
425STDY5139059UnknownERR244115
425STDY5139059UnknownERR244121
425STDY5139060UnknownERR244116
425STDY5139060UnknownERR244122

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

* quick link - http://q.sanger.ac.uk/lvrvrw7l