Plasmodium yoelii

P. yoelii is a murine malaria species, originally isolated from from thicket rats in Central Africa. The species is one of four common murine models which has been utilised within vaccine research. Although the ‘core’ genome shares large block of synteny with human malaria parasites, there are several well-characterised breaks in synteny and the gene organisation in the subtelomeres is substantially different.

Three subspecies are recognized, P. yoelii yoelii, P. yoelii killicki and P. yoelii nigeriensis.

Data Downloads

This project is ongoing and data for this organism will be made available in due course.

[Genome Research Limited]

An initial analysis of a draft genome produced at The Institute for Genome Research by Sanger-sequencing and published by Carlton et al., 2002. From these data P. yoelii has an estimated genome size of 23.1 Mb distributed across 14 chromosomes, but with > 5000 gaps. DNA for this sequencing project was obtained from P. yoelii yoelii 17XNL strain.

Further sequencing of P. yoelii yoelii and several other strains and subspecies is underway using Illumina Sequence-by-synthesis technology. A publication describing the comprehensive re-assembly and annotation is underway. Please refer to Data Use Statement.

  • Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii.

    Carlton JM, Angiuoli SV, Suh BB, Kooij TW, Pertea M, Silva JC, Ermolaeva MD, Allen JE, Selengut JD, Koo HL, Peterson JD, Pop M, Kosack DS, Shumway MF, Bidwell SL, Shallom SJ, van Aken SE, Riedmuller SB, Feldblyum TV, Cho JK, Quackenbush J, Sedegah M, Shoaibi A, Cummings LM, Florens L, Yates JR, Raine JD, Sinden RE, Harris MA, Cunningham DA, Preiser PR, Bergman LW, Vaidya AB, van Lin LH, Janse CJ, Waters AP, Smith HO, White OR, Salzberg SL, Venter JC, Fraser CM, Hoffman SL, Gardner MJ and Carucci DJ

    Nature 2002;419;6906;512-9

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

* quick link - http://q.sanger.ac.uk/gpds85h0