P. yoelii is a murine malaria species, originally isolated from from thicket rats in Central Africa. The species is one of four common murine models which has been utilised within vaccine research. Although the ‘core’ genome shares large block of synteny with human malaria parasites, there are several well-characterised breaks in synteny and the gene organisation in the subtelomeres is substantially different.
Three subspecies are recognized, P. yoelii yoelii, P. yoelii killicki and P. yoelii nigeriensis.
An initial analysis of a draft genome produced at The Institute for Genome Research by Sanger-sequencing and published by Carlton et al., 2002. From these data P. yoelii has an estimated genome size of 23.1 Mb distributed across 14 chromosomes, but with > 5000 gaps. DNA for this sequencing project was obtained from P. yoelii yoelii 17XNL strain.
Further sequencing of P. yoelii yoelii and several other strains and subspecies has been completed using Illumina Sequence-by-synthesis technology. The re-assembly and annotation of P. yoelii yoelii YM and P. yoelii yoelii 17X has been published (PMID:25359557).
A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
BMC biology 2014;12;86
This project is ongoing and data for this organism will be made available in due course.
Data Use Statement
This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.
Please address all sequencing enquiries to: firstname.lastname@example.org