P. ovale is considered as one of the minor parasites of the five human malaria species along with P. malariae because of low prevalence rates in most endemic areas and its relatively mild and chronic nature. The parasite, like P. vivax, has a true relapse mechanism with a dormant liver stage (hypnozoite).
Production of a high quality reference sequence has been attempted from multiple sources of P. ovale DNA. Using the Nigeria I/CDC strain (isolated in 1977 from a Peace Corps worker in Nigeria), provided by John Barnwell (CDC, Atlanta), a low coverage draft has been produced using Sanger sequencing. Further sequencing has been attempted using DNA provided by Colin Sutherland.
Further sequencing and full annotation is planned. We would welcome any source of high quality DNA.
Data Use Statement
This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.
Please address all sequencing enquiries to: firstname.lastname@example.org