The Wellcome Trust Sanger Institute Pathogen Genomics group is undertaking partial shotgun sequencing of a number of different species of Plasmodium. This will serve as useful comparative genomics resource to complement the almost complete Plasmodium falciparum genome. This work is being done in collaboration with Chris Newbold (Oxford) and Mike Turner (Glasgow).

Published Genome Data

The H strain of P. knowlesi was sequenced. The H strain originally came from a naturally infected patient and was acquired in peninsular Malaysia in 1965.

Genomic libraries were constructed from P.knowlesi total genomic DNA in the pUC18 vector. Two ligations have been used to produce a total of 8x coverage of the genome. Genomic DNA was provided by Clemens Kocken (BPRC).

The genome of P. knowlesi (H strain) is published.

• The genome of the simian and human malaria parasite Plasmodium knowlesi.

  Pain A, Böhme U, Berry AE, Mungall K, Finn RD, Jackson AP, Mourier T, Mistry J, Pasini EM, Aslett MA, Balasubrammaniam S, Borgwardt K, Brooks K, Carret C, Carver TJ, Cherevach I, Chillingworth T, Clark TG, Galinski MR, Hall N, Harper D, Harris D, Hauser H, Ivens A, Janssen CS, Keane T, Larke N, Lapp S, Marti M, Moule S, Meyer IM, Ormond D, Peters N, Sanders M, Sanders S, Sargeant TJ, Simmonds M, Smith F, Squares R, Thurston S, Tivey AR, Walker D, White B, Zuiderwijk E, Churcher C, Quail MA, Cowman AF, Turner CM, Rajandream MA, Kocken CH, Thomas AW, Newbold CI, Barrell BG and Berriman M

  Nature 2008;455;7214;799-803

  PUBMED: 18843368; PMC: 2656934; DOI: 10.1038/nature07306