Plasmodium chabaudi

P. chabaudi is one of the four malaria species that infect murine rodents from Central Africa that are infectious to laboratory rodents and easily maintained and transmitted by Anopheles stephensi in the laboratory. It serves as a good model for the human parasites with which it shares high homology in most essential aspects of structure, biochemistry and life cycle. Genome organisation is conserved between rodent and human parasites and the two share detailed synteny.

Data Downloads

[Genome Research Limited]

The nuclear genome of the rodent malaria parasite P. chabaudi AS is 18.8 Mb in size, with a karyotype of 14 chromosomes. The G+C content is approximately 23%.

Published Genome Data

The Wellcome Trust Sanger Institute Pathogen Genomics team initially undertook a partial shotgun sequencing of a number of different species of Plasmodium, including P. chabaudi. This contibues to serve as useful comparative genomics resource to complement the complete Plasmodium falciparum genome. This work was done in collaboration with Chris Newbold (Oxford) and Mike Turner (Glasgow).

Whole genome shotgun sequencing has continued to 8x coverage. Finishing (gap closure) was started in 2008 and will be followed by a publication of the completed and annotated genome sequence.

  • A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses.

    Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR, Kafatos FC, Janse CJ, Barrell B, Turner CM, Waters AP and Sinden RE

    Science (New York, N.Y.) 2005;307;5706;82-6

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

* quick link - http://q.sanger.ac.uk/rt8oo5gk