Leishmania braziliensis

The Leishmania parasite is an intracellular pathogen of the immune system targeting macrophages and dendritic cells. The disease Leishmaniasis affects the populations of 88 counties worldwide with symptoms ranging from disfiguring cutaneous and muco-cutaneous lesions that can cause widespread destruction of mucous membranes to visceral disease affecting the haemopoetic organs.

Data Downloads

[Genome Research Limited]

Unlike previous species sequenced, Leishmania braziliensis is a New World pathogen and currently the only Leishmania genome from the Viannia species group. As well as causing localised cutaneous lesions in affected people, Leishmania braziliensis can also result in a more destructive, progressive infection in mucosal tissue in a proportion of patients.

We have generated a whole genome shotgun, to approximately 5x coverage, of Leishmania braziliensis clone MHOM/BR/75M2904. This project is a collaboration with Universidade de Sao Paulo - FMRP - USP and Debbie Smith (Imperial College).

Published Genome Data

A whole genome shotgun, to approximately 5x coverage, of Leishmania braziliensis clone MHOM/BR/75M2904 was generated. This project is a collaboration with Angela Cruz (Universidade de São Paulo - FMRP - USP) and Debbie Smith (University of York).

Studies

Genome diversity and drug resistance in L. braziliensis

Sample

Strain

Run Accession

L-3CH29BA1UnknownERR377667
LC2368A1UnknownERR377666
LH2206A1UnknownERR377665
LC2141A1UnknownERR377664
LC2125A1UnknownERR377663
LC2320A1UnknownERR377662
LC2043A1UnknownERR377661
LC1586A1UnknownERR377660
LC1580A1UnknownERR377659
LC2041A1UnknownERR377658
LC1569A1UnknownERR377657
LC1578A1UnknownERR377656
LC1568A1UnknownERR377655
LC1565A1UnknownERR377654
LC1412A1UnknownERR377653
LC1409A1UnknownERR377652
PER096A1UnknownERR449710
PER094A1UnknownERR449709
PER086A1UnknownERR449708
PER069A1UnknownERR449707
PER067A1UnknownERR449706
PER065A1UnknownERR449705
PER016A1UnknownERR449704
PER012A1UnknownERR449703
PER011A1UnknownERR449702
PER010A1UnknownERR449701
PER005A1UnknownERR449700
PER002A1UnknownERR449699
PER006A1UnknownERR449698
PER215A1UnknownERR467305
PER212A1UnknownERR467304
PER207A1UnknownERR467303
PER201A1UnknownERR467302
PER186A1UnknownERR467301
PER182A1UnknownERR467300
PER164A1UnknownERR467299
PER163A1UnknownERR467298
PER157A1UnknownERR467297
PER136A1UnknownERR467296
PER130A1UnknownERR467295
PER122A1UnknownERR467294
PER104A1UnknownERR467293
PER014A1UnknownERR449697
LC2398A1UnknownERR449696
LC2367A1UnknownERR449695
LC2353A1UnknownERR449694
LC2321A1UnknownERR449693
LC2318A1UnknownERR449692
LC2289A1UnknownERR449691
LC2284A1UnknownERR449690
LC2177A1UnknownERR449689
LC2176A1UnknownERR449688
LC2147A1UnknownERR449687
LC2143A1UnknownERR449686
LC2123A1UnknownERR449685
CUM68A1UnknownERR471309
CUM704A1UnknownERR471308
CUM52A1UnknownERR471307
CUM49-CH55A1UnknownERR471306
CUM43A1UnknownERR471305
CUM42A1UnknownERR471304
CUM41A1UnknownERR471303
CUM29A1UnknownERR471302
CEN007A1UnknownERR471301
CEN002A1UnknownERR471300
PER260A1UnknownERR471299
PER231A1UnknownERR471298
CUM700A1UnknownERR485669
CUM639A1UnknownERR485668
CUM637A1UnknownERR485667
CUM623A1UnknownERR485666
CUM505A1UnknownERR485665
CUM363A1UnknownERR485664
CUM181A1UnknownERR485663
CUM180A1UnknownERR485662
CUM153A1UnknownERR485661
CUM152A1UnknownERR485660
CUM138A1UnknownERR485659
CUM97A1UnknownERR485658

Leishmania species

Sample

Strain

Run Accession

LbrazilM2904MHOM/BR/75/M2904ERR013296
  • Comparative genomic analysis of three Leishmania species that cause diverse human disease.

    Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, Quail MA, Peters N, Adlem E, Tivey A, Aslett M, Kerhornou A, Ivens A, Fraser A, Rajandream MA, Carver T, Norbertczak H, Chillingworth T, Hance Z, Jagels K, Moule S, Ormond D, Rutter S, Squares R, Whitehead S, Rabbinowitsch E, Arrowsmith C, White B, Thurston S, Bringaud F, Baldauf SL, Faulconbridge A, Jeffares D, Depledge DP, Oyola SO, Hilley JD, Brito LO, Tosi LR, Barrell B, Cruz AK, Mottram JC, Smith DF and Berriman M

    Nature genetics 2007;39;7;839-47

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

* quick link - http://q.sanger.ac.uk/pmb41vxg