Echinococcus multilocularis

Echinococcus multilocularis is a member of the Cyclophyllidea, which comprise the majority of tapeworms that are of medical importance. The disease alveolar echinococcosis, which is caused by the larval stage of E. multilocularis, is considered to be one of the most dangerous worm infections in the world. Larval stages of the related tapeworms E. granulosus and Taenia solium cause the serious and life-threatening diseases cystic echinococcosis and neurocysticercosis, respectively. While E. granulosus, T. solium and T. saginata have a worldwide distribution E. multilocularis has a limited distribution within the Northern Hemisphere. However, recent data indicate a spread of E. multilocularis in Europe, Japan, and North America to areas that were previously free of the parasite leading to the classification of alveolar echinococcosis as an emerging zoonosis.

Data Downloads

[Klaus Brehm laboratory]

This is a Wellcome Trust funded project to sequence the nuclear genome of E. multilocularis, in collaboration with Prof. Klaus Brehm of Institute for Hygiene and Microbiology, University of Wurzburg. The assembled sequence data suggests the genome of E. multilocularis is approximately 110 MB and is being produced by whole genome shotgun sequencing using a mixture of capillary sequencing, illumina sequencing and 454 pyrosequencing. We are also profiling the transcriptome of different life cycle stages of this organism using RNA-seq.

Studies

E.multilocularis transcriptome

Sample

Strain

Run Accession

mm-aRNA2E. multilocularis isolate H95ERR037232
mbup_pfE. multilocularis isolate H95ERR037233

Analysis of RNA expression in tapeworm species

Sample

Strain

Run Accession

246137EmuIngAPS_miIngridERR568829
246137EmuIngAPS_miIngridERR568853
246137EmuIngNonAPS_miIngridERR568828
246137EmuIngNonAPS_miIngridERR568852
EmuIng_8dHU_AB_316318_miIngridERR568826
EmuIng_8dHU_AB_316318_miIngridERR568850
EmuIng_8d_AB_316318_miIngridERR568825
EmuIng_8d_AB_316318_miIngridERR568849
EmH95vivoMC2_296774_miH95ERR568848
EmH95vivoMC2_296774_miH95ERR568824
EmuH95_1B_318177_miH95ERR568823
EmuH95_1B_318177_miH95ERR568847
250942EmuH95MVNoBC_1_miH95ERR568822
250942EmuH95MVNoBC_1_miH95ERR568846
247828EmuH95PC16d_miH95ERR568821
247828EmuH95PC16d_miH95ERR568845
247828EmuH95PC9d_miH95ERR568820
247828EmuH95PC9d_miH95ERR568844
EmuIng48_268268_miIngridERR568843
EmuIng48_268268_miIngridERR568819
246137EmuGH0910APS_miGH09ERR568841
246137EmuGH0910APS_miGH09ERR568817
246137EmuGH0910NonAPS_miGH09ERR568840
246137EmuGH0910NonAPS_miGH09ERR568816
EmuIngHU_318177_miIngridERR568814
EmuIngHU_318177_miIngridERR568838
EmuIng0_318177_miIngridERR568837
EmuIng0_318177_miIngridERR568813
EmH95vivoMC3_296774_miH95ERR568812
EmH95vivoMC3_296774_miH95ERR568836
EmuH95_2B_318177_miH95ERR568811
EmuH95_2B_318177_miH95ERR568835
250942EmuGT10MVNoBC_1_miGT10ERR568834
250942EmuGT10MVNoBC_1_miGT10ERR568810
EmuIng145_268268_miIngridERR568833
EmuIng145_268268_miIngridERR568809
247828Emu8065PC11d_miG8065ERR568832
247828Emu8065PC11d_miG8065ERR568808
EmuG806548_268268_miG8065ERR568831
EmuG806548_268268_miG8065ERR568807
246137EmuMS10APS_miMS10ERR568791
246137EmuMS10APS_miMS10ERR568804
246137EmuMS10NonAPS_miMS10ERR568790
246137EmuMS10NonAPS_miMS10ERR568803
EmuIng_7dHU_AB_316318_miIngridERR568801
EmuIng_7dHU_AB_316318_miIngridERR568788
EmuIng_7d_AB_316318_miIngridERR568800
EmuIng_7d_AB_316318_miIngridERR568787
EmH95vivoMC1_296774_miH95ERR568785
EmH95vivoMC1_296774_miH95ERR568798
EmINGvitro4_296774_miIngridERR568784
EmINGvitro4_296774_miIngridERR568797
250942EmuIngMVNoBC_1_miIngridERR568796
250942EmuIngMVNoBC_1_miIngridERR568783
247828Emu7030PC22d_mi7030ERR568795
247828Emu7030PC22d_mi7030ERR568782
247828Emu7030PC7d_1_2_mi7030ERR568794
247828Emu7030PC7d_1_2_mi7030ERR568781
EmuH9548_268268_miH95ERR568793
EmuH9548_268268_miH95ERR568780
  • The genomes of four tapeworm species reveal adaptations to parasitism.

    Tsai IJ, Zarowiecki M, Holroyd N, Garciarrubio A, Sanchez-Flores A, Brooks KL, Tracey A, Bobes RJ, Fragoso G, Sciutto E, Aslett M, Beasley H, Bennett HM, Cai J, Camicia F, Clark R, Cucher M, De Silva N, Day TA, Deplazes P, Estrada K, Fernández C, Holland PW, Hou J, Hu S, Huckvale T, Hung SS, Kamenetzky L, Keane JA, Kiss F, Koziol U, Lambert O, Liu K, Luo X, Luo Y, Macchiaroli N, Nichol S, Paps J, Parkinson J, Pouchkina-Stantcheva N, Riddiford N, Rosenzvit M, Salinas G, Wasmuth JD, Zamanian M, Zheng Y, Taenia solium Genome Consortium, Cai X, Soberón X, Olson PD, Laclette JP, Brehm K and Berriman M

    Nature 2013;496;7443;57-63

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

* quick link - http://q.sanger.ac.uk/4xu25r73