Candida dubliniensis

The genus Candida contains a range of clinically important yeast-like fungi including the important human pathogen Candida albicans .

Diseases caused by Candida species include superficial infections of the oral cavity and vagina and deep-seated systemic infections, which have a mortality rate of 35-50%. In the majority of cases, these infections occur in immunocompromised individuals. In addition to C. albicans , a number of other species belonging to the genus Candida have increasingly been identified as important human pathogens. One of the most interesting of these species is C. dubliniensis .

C. dubliniensis was first identified and described in 1995. It is particularly associated with oral candidosis in HIV-infected individuals. Prior to this date, C. dubliniensis isolates were misidentified as C. albicans due to their ability to produce germ tubes and chlamydospores, traits previously used for the definitive identification of C. albicans .

[Image from http://commons.wikimedia.org/wiki/File:Candida_albicans.jpg]

Published Genome Data

The Wellcome Trust Sanger Institute Pathogen Genomics group sequenced the genome of Candida dubliniensis in collaboration with Dr. Derek Sullivan, Dr. Gary Moran and Prof. David Coleman of the School of Dental Science, Trinity College, Dublin and Prof. Neil Gow of the Department of Molecular and Cell Biology, University of Aberdeen.

The genome currently consists of 8 chromosomal contigs larger than 100kb containing 262288 reads with a total length of 14.6 Mb. These contigs represent the majority of a haploid assembly. Work is continuing to finalise the assembly and resolve the ribosomal gene repeats.

The sequence data are available via GenBank/EMBL/DDBJ with accession numbers FM992688 to FM992695.

Selected Publications

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

* quick link - http://q.sanger.ac.uk/hcav9pqo