We have sequenced the whole genome sequences of three Streptococcus suis strains from the same lineage: one from European pigs, and two from human cases from China and Vietnam.

The strains are:

• P1/7 was isolated from an ante-mortem blood culture from a pig dying with meningitis, and is sequence type (ST)1 by MLST
• BM407 was isolated from CSF from a human case of meningitis in Ho Chi Minh City, Vietnam in 2004, and is is ST1
• SC84 was isolated from a case of streptococcal toxic shock-like syndrome in Sichuan Province, China in 2005, and is is ST7, a single locus varient of ST1

We have also undertaken some deep sequencing within the ST1 lineages, examining human and pig isolates from in and around Ho Chi Minh City, Vietnam

Collaborators

Stephen Baker, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

Constance Schultsz, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

Published Genome Data

The sequences and annotations of the Streptococcus suis P1/7, SC84 and BM407 genomes have been deposited in the EMBL database under accession numbers AM946016, FM252031, FM252032 and FM252033 respectively.

Shotgun and assembly data from these projects are available from our FTP site.

• Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.

  Holden MT, Hauser H, Sanders M, Ngo TH, Cherevach I, Cronin A, Goodhead I, Mungall K, Quail MA, Price C, Rabbinowitsch E, Sharp S, Croucher NJ, Chieu TB, Mai NT, Diep TS, Chinh NT, Kehoe M, Leigh JA, Ward PN, Dowson CG, Whatmore AM, Chanter N, Iversen P, Gottschalk M, Slater JD, Smith HE, Spratt BG, Xu J, Ye C, Bentley S, Barrell BG, Schultsz C, Maskell DJ and Parkhill J

  PloS one 2009;4;7;e6072

  PUBMED: 19603075; PMC: 2705793; DOI: 10.1371/journal.pone.0006072