The Sanger Institute has been funded by the Wellcome Trust/Beowulf Genomics to sequence the genomes of strains from serogroups A and C:
N. meningitidis serogroup A strain Z2491, in collaboration with Brian Spratt (Imperial College, UK) and Mark Achtman (University of Cork, Ireland)
N. meningitidis serogroup C strain FAM18, in collaboration with Mark Achtman (University of Cork, Ireland)
We also have a broad ranging collaboration with Martin Maiden (University of Oxford) looking at diversity across the genus, within species, within clones and within infections.
Published Genome Data
The genomes of The genome of Neisseria meningitidis serogroup A strain Z2491, Neisseria meningitidis serogroup C strain FAM18 and Neisseria lactamica 020-06 are all available in the EMBL/GenBank databases with accession numbers AL157959, AM421808 and FN995097respectively.
Shotgun and assembly data from these projects are available from the our FTP site.
Studies
- Neisseria meningitidis diversity
- Neisseria meningitidis study
- Emergence and spread of antibiotic resistant Neisseria gonorrhoeae in the US
- Discovery of sequence diversity in Neisseria spp.
- Genome sequencing of Neisseria gonorrhoeae isolates
- Neisseria meningitidis transformation study
- Neisseria lactamica Colonisation
- Neisseria meningitidis variation during infection
Neisseria meningitidis diversity
Neisseria meningitidis study
Emergence and spread of antibiotic resistant Neisseria gonorrhoeae in the US
Discovery of sequence diversity in Neisseria spp.
Genome sequencing of Neisseria gonorrhoeae isolates
Neisseria meningitidis transformation study
Sample | Strain | Run Accession |
|---|---|---|
| 624s01 | MC58 | ERR021998 |
| 624s02 | MC58 | ERR021999 |
| 624s03 | MC58 | ERR022000 |
| 624s04 | Fam18 | ERR022001 |
Neisseria lactamica Colonisation
Neisseria meningitidis variation during infection
Sample | Strain | Run Accession |
|---|---|---|
| NMBI | Z8.14 | ERR015596 |
| 243 | Z8.14 | ERR015597 |
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Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06.
BMC genomics 2010;11;652
PUBMED: 21092259; PMC: 3091772; DOI: 10.1186/1471-2164-11-652
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Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.
PLoS genetics 2007;3;2;e23
PUBMED: 17305430; PMC: 1797815; DOI: 10.1371/journal.pgen.0030023
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Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.
Nature 2000;404;6777;502-6
PUBMED: 10761919; DOI: 10.1038/35006655
