The Sanger Institute has been funded by the Wellcome Trust/Beowulf Genomics to sequence the genomes of strains from serogroups A and C:

N. meningitidis serogroup A strain Z2491, in collaboration with Brian Spratt (Imperial College, UK) and Mark Achtman (University of Cork, Ireland)

N. meningitidis serogroup C strain FAM18, in collaboration with Mark Achtman (University of Cork, Ireland)

We also have a broad ranging collaboration with Martin Maiden (University of Oxford) looking at diversity across the genus, within species, within clones and within infections.

Published Genome Data

The genomes of The genome of Neisseria meningitidis serogroup A strain Z2491 and Neisseria meningitidis serogroup C strain FAM18 are both available in the EMBL/GenBank databases with accession numbers AL157959 and AM421808 respectively.

Shotgun and assembly data from these projects are available from the our FTP site.

• Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.

  Bentley SD, Vernikos GS, Snyder LA, Churcher C, Arrowsmith C, Chillingworth T, Cronin A, Davis PH, Holroyd NE, Jagels K, Maddison M, Moule S, Rabbinowitsch E, Sharp S, Unwin L, Whitehead S, Quail MA, Achtman M, Barrell B, Saunders NJ and Parkhill J

  PLoS genetics 2007;3;2;e23

  PUBMED: 17305430; PMC: 1797815; DOI: 10.1371/journal.pgen.0030023

• Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.

  Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, Klee SR, Morelli G, Basham D, Brown D, Chillingworth T, Davies RM, Davis P, Devlin K, Feltwell T, Hamlin N, Holroyd S, Jagels K, Leather S, Moule S, Mungall K, Quail MA, Rajandream MA, Rutherford KM, Simmonds M, Skelton J, Whitehead S, Spratt BG and Barrell BG

  Nature2000;404;6777;502-6

  PUBMED: 10761919; DOI: 10.1038/35006655