The Wellcome Trust and DEFRA has funded the Sanger Instiute to sequence reference genomes for Mycobacterium africanum
Mycobacterium bovis strains AF2122/97 and BCG Pasteur
Mycobacterium canetti
Mycobacterium leprae
Mycobacterium marinum
Mycobacterium microti
Mycobacterium tuberculosis
In collaboration with
Dr. Bouke de Jong, Bacterial Diseases Programme, MRC Laboratories, The Gambia
Prof. Stewart Cole, Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Dr. Glyn Hewinson, Veterinary Laboratories Agency, UK.
Dr. Roland Brosch, Unit de Genetique Moleculaire Bacterienne, Institut Pasteur.
Dr. Lalita Ramakrishnan, University of Washington, Seattle, USA.
Dr. John Davies, Department of Microbiology, Monash University, Australia.
Dr. Pamela Small, Department of Microbiology, University of Tennessee, Knoxville, USA.
Dr. Paul Johnson, Department of Infections Diseases, Monash Medical Centre, Australia.
The Sanger Institute has also initiated a Wellcome Trust funded genomics program to look at various aspect of
mycobacterial evolution and epidemiology in collaboration with Douglas Young and Sebastian Gagneux, MRC National
Institute for Medical Research, Division of Mycobacterial Research, London, UK.
Francis Drobniewski, Barts and The London School of Medicine and Dentistry, London, UK.
Mike Prentice, Department of Microbiology, University College Cork, Cork, Ireland.
Dick van Soolingen, National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Sandra Newton, Imperial College, London, UK.
Derrick Crook, Oxford University, Oxford, UK.
Helen Donoghue, UCL School of Life and Medical Sciences, London, UK.
Noel Smith, Centre for the Study of Evolution, University of Sussex, Brighton, UK.
Dr. Glyn Hewinson, Veterinary Laboratories Agency, UK.
Dr. Roland Brosch, Unit de Genetique Moleculaire Bacterienne, Institut Pasteur.
Published Genome Data
The following genomes are available from EMBL/GenBank with their respective accession numbers
Mycobacterium bovis BCG Pasteur 1173P2 - AM408590
Mycobacterium bovis subsp. bovis AF2122/97 - BX248333
Mycobacterium leprae - AL450380
Mycobacterium tuberculosis H37Rv - AL123456
Mycobacterium marinum ATCC BAA-535 - CP000854. Plasmid: CP000895
Shotgun and assembly data from these projects are available from the FTP link on the right.
Discovery of sequence diversity in Mycobacterium tuberculosis
Sample | Strain | Run Accession |
|---|---|---|
| N438R | N438R | ERR027082 |
| N438R | N438R | ERR027083 |
Whole genome sequencing of Mycobacterium tuberculosis from a population in Malawi - transmission dynamics and associations with HIV
Evolution of drug resistance in Mycobacterium tuberculosis
Discovery of sequence diversity in Mycobacterium tuberculosis (Russia collection)
Discovery of sequence diversity in Mycobacterium bovis
Sample | Strain | Run Accession |
|---|---|---|
| MbovisAN5 | AN5 | ERR016863 |
| Mbovis1121_T17 | 1121_T17 | ERR016864 |
| M.bovis2451_T25 | AF2451/01 | ERR016865 |
| Mbovis1307_T35 | 1307_T35 | ERR016866 |
| Mbovis2122_PDIMpos | 2122_PDIMpos | ERR016867 |
| Mbovis2122_PDIMneg | 2122_PDIMneg | ERR016868 |
| MbT17R | AF1121/01 | ERR016861 |
| MbT25R | AF2451/01 | ERR032132 |
| MbT35R | AF1307/01 | ERR032133 |
| MbAN5R | AN5 | ERR032134 |
The genome sequence of antelope associated clade of the Mycobacterium tuberculosis complex (strain VIC4031ORYX)
Sample | Strain | Run Accession |
|---|---|---|
| VIC4031ORYX | VIC4031ORYX | ERR015582 |
Deep sequencing within the Streptococcus pneumoniae antibiotic resistant pandemic clone PMEN1
Sample | Strain | Run Accession |
|---|
Mycobacterium tuberculosis from archeological samples
Sample | Strain | Run Accession |
|---|---|---|
| 92chest | Unknown | ERR037234 |
| 121pleural | Unknown | ERR037235 |
Discovery of sequence diversity in Mycobacterium tuberculosis during outbreak
Sample | Strain | Run Accession |
|---|---|---|
| H37Rv | H37Rv | ERR045759 |
| Gurung024 | Gurung 024 | ERR045760 |
| Gurung256 | Gurung 256 | ERR045761 |
| Gurung333 | Gurung 333 | ERR045762 |
| NPH | NPH | ERR045763 |
Discovery of sequence diversity in Mycobacterium tuberculosis (key strains)
Mycobacterium microti genome diversity
Sample | Strain | Run Accession |
|---|---|---|
| OV254 | OV254 | ERR027294 |
| ATCC35782 | ATCC35782 | ERR027295 |
| MausIII | MausIII | ERR027296 |
| MausIV | MausIV | ERR027297 |
| 942272 | 94-2272 | ERR027298 |
| MUSA | M-USA | ERR027299 |
| MVU | M-VU | ERR027300 |
Epidemiology of tuberculosis
Mycobacterium canetti genome assembly
Sample | Strain | Run Accession |
|---|---|---|
| CAN | CIPT140010059 | ERR015598 |
Mycobacterium avium subspecies paratuberculosis diversity
Mycobacterium tuberculosis pilot
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Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.
Genome research 2008;18;5;729-41
PUBMED: 18403782; PMC: 2336800; DOI: 10.1101/gr.075069.107
-
The complete genome sequence of Mycobacterium bovis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100;13;7877-82
PUBMED: 12788972; PMC: 164681; DOI: 10.1073/pnas.1130426100
-
Massive gene decay in the leprosy bacillus.
Nature 2001;409;6823;1007-11
PUBMED: 11234002; DOI: 10.1038/35059006
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature 1998;393;6685;537-44
PUBMED: 9634230; DOI: 10.1038/31159
