Corynebacterium

The genus Corynebacterium consists of Gram-positive aerobic, rod shaped bacteria. These include Corynebacterium diphtheriae which produces a potent bacteriophage-encoded protein exotoxin, diphtheria toxin, which causes the symptoms of diphtheria. This potentially fatal infectious disease is controlled in many developed countries by an effective immunisation programme. However, the disease has made a dramatic return in recent years, in particular within the Eastern European region.

Data Downloads

C. diphtheriae biotype gravis strain NCTC13129 was isolated in 1997 from a 72-year-old female with clinical diphtheria who had returned to the UK from a Baltic cruise.

Published Genome Data

The C. diphtheriae NCTC 13129 genome is composed of a single circular chromosome of 2,488,635 bp, and was sequenced in collaboration with Dr. Androulla Efstratiou of the W.H.O. collaborating centre for diphtheria, Respiratory and Systemic Infection Laboratory, at the Health Protection Agency.

The fully annotated genome is available from the EMBL/GenBank databases with accession number BX248353.

Shotgun and assembly data from this project are available from our FTP site.

Studies

NCTC 3000
SampleStrainRun Accession
3012STDY5814528NCTC11397ERR550493
3012STDY5814528NCTC11397ERR550508
3012STDY5814528NCTC11397ERR550510
3012STDY6362597NCTC4656ERR1424486
3012STDY6362599NCTC4681ERR1424487
3012STDY6362601NCTC7908ERR1424488
3012STDY6362602NCTC11140ERR1424489
3012STDY6362603NCTC11142ERR1424490
3012STDY6383826NCTC8660ERR1456747
3012STDY6387764NCTC8666ERR1466823
3012STDY6387766NCTC10284ERR1475869
3012STDY6430053NCTC10285ERR1588636
3012STDY6430054NCTC8639ERR1588637
3012STDY6430055NCTC10838ERR1588638
3012STDY6430057NCTC11914ERR1588645
3012STDY6430058NCTC11917ERR1588646
3012STDY6435336NCTC1386ERR1599921
3012STDY6430051NCTC11913ERR1612403
3012STDY6430051NCTC11913ERR1716474
3012STDY6439496NCTC10604ERR1612404
3012STDY6439497NCTC10606ERR1612405
3012STDY6439498NCTC10288ERR1612406
3012STDY6439502NCTC7448ERR1612408
3012STDY6593595NCTC7910ERR1892119
3012STDY6593599NCTC3224ERR1892123
3012STDY6593599NCTC3224ERR2125652
3012STDY6593599NCTC3224ERR2125826
3012STDY6593600NCTC9864ERR1892124
3012STDY6593601NCTC10254ERR1892102
3012STDY6593602NCTC949ERR1892103
3012STDY6606167NCTC764ERR1911794
3012STDY6617323UnknownERR1948261
3012STDY6617324UnknownERR1948262
3012STDY6617325UnknownERR1948263
3012STDY6617332UnknownERR1954482
3012STDY6622176NCTC13391_1ERR1954485
3012STDY6622194NCTC13015_1ERR1954499
3012STDY6651987NCTC7243ERR2125646
3012STDY6667048NCTC3655ERR2125688
3012STDY6667056NCTC934_1ERR2125693
3012STDY6733939NCTC7449ERR2125787
3012STDY6839330NCTC9755ERR2125858
3012STDY6839331NCTC10289ERR2125859
3012STDY6934487NCTC3450ERR2171924
3012STDY6981869NCTC10206ERR2199655
3012STDY7040872NCTC11141ERR2237797
3012STDY7069323NCTC11398ERR2246642
3012STDY7069329NCTC12078ERR2246647

Bibliography

  • The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.

    Cerdeño-Tárraga AM, Efstratiou A, Dover LG, Holden MT, Pallen M, Bentley SD, Besra GS, Churcher C, James KD, De Zoysa A, Chillingworth T, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Quail MA, Rabbinowitsch E, Rutherford KM, Thomson NR, Unwin L, Whitehead S, Barrell BG and Parkhill J

    Nucleic acids research 2003;31;22;6516-23

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

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