Bacteroides is a genus of Gram-negative, obligately anaerobic bacteria.
Bacteroides fragilis is usually a commensal organism, forming a large component of the normal human gut microbiota. However it is also an important opportunistic pathogen, with the potential to severly limit the success of gastro-intestinal surgery.
The Sanger Institute has been funded by the Wellcome Trust to sequence the genomes of two Bacteroides fragilis, strains NCTC9343 and 638R, in collaboration with Sheila Patrick (Queen's University of Belfast, UK), Garry Blakely (University of Edinburgh, UK), Val Abratt of the Department of Molecular anf Cell Biology at the University of Cape Town (South Africa), Prof. Brian Duerden (University of Wales College of Medicine, UK) and Prof. Ian Poxton (University of Edinburgh Medical School, UK).
Extensive DNA inversions in the B. fragilis genome control variable gene expression.
Cerdeño-Tárraga AM, Patrick S, Crossman LC, Blakely G, Abratt V, Lennard N, Poxton I, Duerden B, Harris B, Quail MA, Barron A, Clark L, Corton C, Doggett J, Holden MT, Larke N, Line A, Lord A, Norbertczak H, Ormond D, Price C, Rabbinowitsch E, Woodward J, Barrell B and Parkhill J
This sequencing centre plans on publishing the completed and annotated sequences in a
peer-reviewed journal as soon as possible. Permission of the principal investigator should be
obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or
genome scale. See our data sharing policy.