Mouse & zebrafish genetics

The model organism programme carries out research to understand biological processes and generates and distributes a wide range of community resources, accelerating research globally.

Its principal focus is on Mouse and zebrafish genetics, information and biological resources. In-house research focuses on the biological function of genes identified in other Sanger Institute programmes, such as Human genetics and the Cancer Genome Project, or of potential importance to human development and health.

  • Projects - a list of Faculty-led research projects in mouse and zebrafish genetics
  • Collaborations and resources - a list of collaborations and resources in Mouse and zebrafish genetics in which the Sanger Institute plays a leading role

[Genome Research Limited]

Projects

*Cell surface signalling laboratory
Gavin Wright's team aims to discover entirely new signalling pathways by identifying novel cell surface receptor-ligand pairs
*Epigenetic mechanisms in health and disease
Adrian Bird's Associate Faculty group studies the way chemical marking of chromosomes affects the activity of the genome in normal and diseased cells
* Epigenetic reprogramming
Wolf Reik's Associate Faculty group studies how processes that add additional information to the genome (known as epigenetics) enable reprogramming in stem cells and disease
*Experimental cancer genetics
David Adams' team aims to understand mechanisms of cancer development by generating and characterising mutations in mice
*Gene expression genomics
Sarah Teichmann's team uses genomic approaches to study global regulation of gene expression in the mouse immune system
*Genetics of behaviour
Darren Logan's team aims to understand the genes that enable animals to detect and respond to social signals with an appropriate behaviour
*Haematological cancer genetics
George Vassiliou's team studies the genes and genetic pathways involved in the development of haematological cancers
*Mouse cancer genetics
Pentao Liu's team uses genetic, genomic and biochemical approaches to understand cancer biology in mouse models
*Archived Page: Mouse developmental genetics
Bill Skarnes' team used mouse embryonic stem cells as a model of early development in the womb
*Mouse genomics
Allan Bradley's team uses disruption of genes in mouse embryonic stem cells to discover genes involved in cellular processes and diseases
*Systems biology of bone
Vijay Yadav's team uses mice as a model organism to identify the genes and their interactions that determine bone mass
*Vertebrate development and genetics
Derek Stemple's team aims to understand the mechanistic basis of human genetic diseases by using zebrafish and Xenopus tropicalis as models

Collaborations and resources

* Ensembl genome browser
Produces genome databases for vertebrates and other eukaryotic species and makes this information freely available online
*Genome analysis pipelines
The pipelines are dedicated to high-throughput sample logistics, genome-wide data generation, PCR target preparation for re-sequencing, genotyping, data quality control, analysis and storage
* Genome Reference Consortium (GRC)
Aims to ensure that the human, mouse and zebrafish reference assemblies are biologically relevant by closing gaps, fixing errors and representing complex variation
*HAVANA
The HAVANA group provides the manual annotation of human, mouse, zebrafish and other vertebrate genomes that appears in the Vega browser
*High Throughput Gene Targeting (HTGT)
Generates conditional targeted mutations in C57BL/6 embryonic stem cells
*Mouse Strain Genome Sequencing
Sequenced 17 key mouse strain genomes to provide genomic foundation for phenotypic study
*Mouse Resource Portal
Provides unified access to mouse resources from the Institute or its collaborators, including BACs, gene targeting vectors, targeted embryonic stem cells, mutant mouse lines, and phenotypic data
*Mutagenic Insertion and Chromosome Engineering Resource (MICER)
Provides vector sequences and information on using MICER vectors for generating knockout mice and for chromosome engineering for the scientific community
*Non-Obese Diabetic (NOD) Mouse
Sequenced the Insulin-dependent diabetes (Idd) regions in the non-obese diabetic (NOD) mouse
*Sequencing
The Institute harnesses cutting-edge technologies to generate DNA sequence in order to answer questions about biology and disease
*Sanger Institute-EBI Single-Cell Genomics Centre
Explores the DNA, RNA and epigenetic features of single cells in order to better understand normal biology and disease
*Sanger Institute Gene Trap Resource (SIGTR)
Catalogues more than 10,000 characterised lacZ-tagged insertional mutations in 129 mouse embryonic stem cells
* Vertebrate Genome Annotation database (VEGA)
A central repository for high-quality manual annotation of vertebrate finished genome sequence, including annotation of the mouse and zebrafish genomes
*Xenopus tropicalis EST Project
Generates 5' EST sequences from three Xenopus tropicalis cDNA libraries and makes these clones available through Geneservice
*Zebrafish Mutation Resource
Identifies, phenotypes and distributes a large number of chemically mutagenised zebrafish lines
*Zebrafish Sequencing Project
Produces regular sequence annotations and assemblies data through clone mapping and sequencing from BAC and PAC libraries and whole genome shotgun sequencing
*ZF-MODELS
Data on mutations, microarrays and gene expression are mapped onto the genome, producing disease models, drug targets and insight into pathways of gene regulation
* quick link - http://q.sanger.ac.uk/en0e7zbf