Projects
Cell surface signalling laboratory- Gavin Wright's team aims to discover entirely new signalling pathways by identifying novel cell surface receptor-ligand pairs
Experimental cancer genetics- David Adams' team aims to understand mechanisms of cancer development by generating and characterising mutations in mice
Genes to cognition- Seth Grant's team carries out genome-wide and gene-specific studies to understand synapse and multiprotein mechanisms
Genetics of deafness- Karen Steel's team studies mice with hearing impairments to identify genes associated with deafness and determine their function
Genetics of instinctive behaviour- Darren Logan's team investigates the sensory mechanisms that regulate stereotyped social behaviour by altering selected genes in mice
Haematological cancer genetics- George Vassiliou's team studies the genes and genetic pathways involved in the development of haematological cancers
Mouse cancer genetics- Pentao Liu's team uses genetic, genomic and biochemical approaches to understand cancer biology in mouse models
Mouse developmental genetics- Bill Skarnes' team uses mouse embryonic stem cells as a model of early development in the womb
Mouse genomics- Allan Bradley's team uses disruption of genes in mouse embryonic stem cells to discover genes involved in cellular processes and diseases
Systems biology of bone- Vijay Yadav's team uses mice as a model organism to identify the genes and their interactions that determine bone mass
Vertebrate development and genetics- Derek Stemple's team aims to understand the mechanistic basis of human genetic diseases by using zebrafish and Xenopus tropicalis as models
Collaborations and resources
Ensembl genome browser- Produces genome databases for vertebrates and other eukaryotic species and makes this information freely available online
Genome analysis pipelines- The pipelines are dedicated to high-throughput sample logistics, genome-wide data generation, PCR target preparation for re-sequencing, genotyping, data quality control, analysis and storage
Genome Reference Consortium (GRC)- Aims to ensure that the human, mouse and zebrafish reference assemblies are biologically relevant by closing gaps, fixing errors and representing complex variation
HAVANA- The HAVANA group provides the manual annotation of human, mouse, zebrafish and other vertebrate genomes that appears in the Vega browser
High Throughput Gene Targeting (HTGT)- Generates conditional targeted mutations in C57BL/6 embryonic stem cells
Mouse Resource Portal- Provides unified access to mouse resources from the Institute or its collaborators, including BACs, gene targeting vectors, targeted embryonic stem cells, mutant mouse lines, and phenotypic data
Mutagenic Insertion and Chromosome Engineering Resource (MICER)- Provides vector sequences and information on using MICER vectors for generating knockout mice and for chromosome engineering for the scientific community
Sequencing- The Institute harnesses cutting-edge technologies to generate DNA sequence in order to answer questions about biology and disease
Sanger Institute Gene Trap Resource (SIGTR)- Catalogues more than 10,000 characterised lacZ-tagged insertional mutations in 129 mouse embryonic stem cells
Vertebrate Genome Annotation database (VEGA)- A central repository for high-quality manual annotation of vertebrate finished genome sequence, including annotation of the mouse and zebrafish genomes
Xenopus tropicalis EST Project- Generates 5' EST sequences from three Xenopus tropicalis cDNA libraries and makes these clones available through Geneservice
Zebrafish Mutation Resource- Identifies, phenotypes and distributes a large number of chemically mutagenised zebrafish lines
Zebrafish Sequencing Project- Produces regular sequence annotations and assemblies data through clone mapping and sequencing from BAC and PAC libraries and whole genome shotgun sequencing
ZF-MODELS- Data on mutations, microarrays and gene expression are mapped onto the genome, producing disease models, drug targets and insight into pathways of gene regulation
