Cellular genetics

The Cellular Genetics programme explores the way in which natural variation in the genome affects how human cells function in health and in disease. The results help researchers to understand disease processes.

The programme makes use of human induced pluripotent stem (iPS) cells to follow the effects of genome variation on the development of tissues and organs in the body. Human iPS cells are derived from mature tissue cells whose genetic clocks have been reset to turn them back into stem cells, giving them the ability to develop into almost every cell type in the body.

Our researchers are developing stem cell resources, such as human iPS cells from thousands of apparently healthy people and specific patient groups, and are using these (and other) cell resources to examine cellular activity to better understand biology in health and disease.

• Projects - a list of Faculty-led research projects in cellular genetics
• Groups - a list of Faculty-led research groups in cellular genetics
• Collaborations and resources - a list of collaborations and resources in cellular genetics in which the Sanger Institute plays a leading role

[Genome Research Limited]