Bioinformatics

Computational genome biology: Chris Ponting's Associate Faculty group analyses next-generation sequencing data to better understand basic biological and disease processes
Genome informatics: Richard Durbin's team explores various types of sequence and variation informatics, often involving evolutionary analysis
Population and evolutionary genomics of gene regulation: Explores how changes in gene regulation affect disease susceptibility and human evolution

Population genomics of molecular phenotypes: Ville Mustonen's team develops population genetic methods for integrated sequencing and functional data to help explain natural variation
Using outbred genetic variation to understand basic biology: Ewan Birney's group is using genomic data to study basic biological process and changes in shape and form in whole organisms and individual cells
Vertebrate genome analysis: Tim Hubbard's team generates vertebrate genome annotations and maintains the reference human, mouse and zebrafish sequences

1000 Genomes project: Sequences the genomes of a large number of people, to provide a comprehensive resource on human genetic variation
Distributed Annotation System (DAS): A data exchange protocol for open sharing of biological information
ENCODE and GENCODE: Aims to identify all functional elements across the entire human genome sequence and annotate evidence-based gene features at a high accuracy
Ensembl genome browser: Produces genome databases for vertebrates and other eukaryotic species and makes this information freely available online
Genome Reference Consortium (GRC): Aims to ensure that the human, mouse and zebrafish reference assemblies are biologically relevant by closing gaps, fixing errors and representing complex variation
GeneDB: Provides the latest sequence data and annotation for pathogens sequenced at the Institute and tools to aid the community in accessing and obtaining the maximum value from these data
HAVANA: The HAVANA group provides the manual annotation of human, mouse, zebrafish and other vertebrate genomes that appears in the Vega browser
iPfam: Describes Pfam domain interactions that are observed in Protein Data Bank entries
MEROPS: Provides the internationally recognised classification of peptidases and their inhibitors

miRBase: A searchable database of published microRNA sequences and annotation with downloadable data
MitoCheck: An integrated research project which systematically studies the regulation of mitosis in human cells
Pfam: Provides a classification of proteins into families and domains using hidden Markov models
Rfam: Provides a classification of RNA families using covariance models
Sanger Institute-EBI Single-Cell Genomics Centre: Explores the DNA, RNA and epigenetic features of single cells in order to better understand normal biology and disease
Tiffin: A database of predicted regulatory motifs, a subset with predicted functional annotation
TreeFam: Provides curated phylogenetic trees of animal genes, that give reliable ortholog and paralog assignments
UK10K: Aims to understand the link between low-frequency and rare genetic changes, and human disease by studying the genetic code of 10,000 people
Vertebrate Genome Annotation database (VEGA): Central database repository for high-quality manual annotation of vertebrate finished genome sequence