Projects
Classification of proteins and RNAs- Alex Bateman's team classifies proteins and RNAs into families to allow researchers to understand their properties and functions
Genome informatics- Richard Durbin's team explores various types of sequence and variation informatics, often involving evolutionary analysis
Population genomics of molecular phenotypes- Ville Mustonen's team develops population genetic methods for integrated sequencing and functional data to help explain natural variation
Vertebrate genome analysis- Tim Hubbard's team generates vertebrate genome annotations and maintains the reference human, mouse and zebrafish sequences
Collaborations and resources
1000 Genomes project- Sequences the genomes of a large number of people, to provide a comprehensive resource on human genetic variation
Distributed Annotation System (DAS)- A data exchange protocol for open sharing of biological information
ENCODE and GENCODE- Aims to identify all functional elements across the entire human genome sequence and annotate evidence-based gene features at a high accuracy
Ensembl genome browser- Produces genome databases for vertebrates and other eukaryotic species and makes this information freely available online
Genome Reference Consortium (GRC)- Aims to ensure that the human, mouse and zebrafish reference assemblies are biologically relevant by closing gaps, fixing errors and representing complex variation
GeneDB- Provides the latest sequence data and annotation for pathogens sequenced at the Institute and tools to aid the community in accessing and obtaining the maximum value from these data
HAVANA- The HAVANA group provides the manual annotation of human, mouse, zebrafish and other vertebrate genomes that appears in the Vega browser
iPfam- Describes Pfam domain interactions that are observed in Protein Data Bank entries
MEROPS- Provides the internationally recognised classification of peptidases and their inhibitors
miRBase- A searchable database of published microRNA sequences and annotation with downloadable data
MitoCheck- An integrated research project which systematically studies the regulation of mitosis in human cells
Pfam- Provides a classification of proteins into families and domains using hidden Markov models
Rfam- Provides a classification of RNA families using covariance models
Tiffin- A database of predicted regulatory motifs, a subset with predicted functional annotation
TreeFam- Provides curated phylogenetic trees of animal genes, that give reliable ortholog and paralog assignments
UK10K- Aims to understand the link between low-frequency and rare genetic changes, and human disease by studying the genetic code of 10,000 people
Vertebrate Genome Annotation database (VEGA)- Central database repository for high-quality manual annotation of vertebrate finished genome sequence
