Klaudia Walter, PhD | Senior Staff Scientist

Walter, Klaudia

Klaudia works as a senior staff scientist in Nicole Soranzo's team. She is a mathematician and statistician by training and she has contributed to the UK10K project and the 1000 Genomes Project.

When I first started at the Sanger Institute, I joined Matt Hurles' team as a postdoctoral fellow to work mainly on structural variations in the 1000 Genomes Project. Later I moved to Nicole Soranzo's team as a statistical geneticist to work on many different aspects in the UK10K project, especially variant sites and sample QC, association analyses of common and rare variants, population structure, loss-of-function variants and large deletions.

Publications

  • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.

    Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C et al.

    Nature genetics 2016;48;11;1303-1312

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • An integrated map of structural variation in 2,504 human genomes.

    Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A et al.

    Nature 2015;526;7571;75-81

  • A global reference for human genetic variation.

    , Auton A, Brooks LD, Durbin RM, Garrison EP et al.

    Nature 2015;526;7571;68-74

  • Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

    Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A et al.

    Nature 2015;526;7571;112-7

  • A systematic survey of loss-of-function variants in human protein-coding genes.

    MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J et al.

    Science (New York, N.Y.) 2012;335;6070;823-8

  • Mapping copy number variation by population-scale genome sequencing.

    Mills RE, Walter K, Stewart C, Handsaker RE, Chen K et al.

    Nature 2011;470;7332;59-65

  • Striking nucleotide frequency pattern at the borders of highly conserved vertebrate non-coding sequences.

    Walter K, Abnizova I, Elgar G and Gilks WR

    Trends in genetics : TIG 2005;21;8;436-40

  • An interactive genome browser of association results from the UK10K cohorts project.

    Geihs M, Yan Y, Walter K, Huang J, Memari Y et al.

    Bioinformatics (Oxford, England) 2015;31;24;4029-31

  • A global reference for human genetic variation.

    , Auton A, Brooks LD, Durbin RM, Garrison EP et al.

    Nature 2015;526;7571;68-74

  • An integrated map of structural variation in 2,504 human genomes.

    Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A et al.

    Nature 2015;526;7571;75-81

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

    Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A et al.

    Nature 2015;526;7571;112-7

  • Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel.

    Huang J, Howie B, McCarthy S, Memari Y, Walter K et al.

    Nature communications 2015;6;8111

  • Whole-genome sequence-based analysis of thyroid function.

    Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M et al.

    Nature communications 2015;6;5681

  • A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.

    Timpson NJ, Walter K, Min JL, Tachmazidou I, Malerba G et al.

    Nature communications 2014;5;4871

  • Estimating genome-wide significance for whole-genome sequencing studies.

    Xu C, Tachmazidou I, Walter K, Ciampi A, Zeggini E et al.

    Genetic epidemiology 2014;38;4;281-90

  • An integrated map of genetic variation from 1,092 human genomes.

    1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA et al.

    Nature 2012;491;7422;56-65

  • A systematic survey of loss-of-function variants in human protein-coding genes.

    MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J et al.

    Science (New York, N.Y.) 2012;335;6070;823-8

  • Mapping copy number variation by population-scale genome sequencing.

    Mills RE, Walter K, Stewart C, Handsaker RE, Chen K et al.

    Nature 2011;470;7332;59-65

  • A map of human genome variation from population-scale sequencing.

    1000 Genomes Project Consortium, Abecasis GR, Altshuler D, Auton A, Brooks LD et al.

    Nature 2010;467;7319;1061-73

  • Accurate whole human genome sequencing using reversible terminator chemistry.

    Bentley DR, Balasubramanian S, Swerdlow HP, Smith GP, Milton J et al.

    Nature 2008;456;7218;53-9

  • Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens.

    Walter K, Fulford AJ, McBeath R, Joseph S, Jones FM et al.

    Journal of immunology (Baltimore, Md. : 1950) 2006;177;8;5490-8

  • Striking nucleotide frequency pattern at the borders of highly conserved vertebrate non-coding sequences.

    Walter K, Abnizova I, Elgar G and Gilks WR

    Trends in genetics : TIG 2005;21;8;436-40

  • Highly conserved non-coding sequences are associated with vertebrate development.

    Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK et al.

    PLoS biology 2005;3;1;e7

  • Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel.

    Joseph S, Jones FM, Walter K, Fulford AJ, Kimani G et al.

    The Journal of infectious diseases 2004;190;4;835-42

Career/Research Highlights

Walter, Klaudia
Klaudia's Timeline
2016

Senior Staff Scientist at Sanger Institute

2011

Staff Scientist at Sanger Institute

2008

PhD in Comparative Genomics (University of Cambridge)

2007

Postdoctoral Fellow at Sanger Institute

2003

MSc in Statistics (University of Sheffield)

2002

Database Manager/Statistician at Department of Pathology (University of Cambridge)

2001

Diploma in Statistics (Open University)

2000

Internship at EBI

1987

Mag.rer.nat. in Mathematics and Physical Education (University of Vienna)