Dr Elisa Viciani | Postdoctoral Fellow

Viciani, Elisa

Elisa's work combines microbiology, molecular biology and cell biology to understand the complexity of intestinal communities as well as their genetic and metabolic potential.

Studying what constitutes a healthy gut microbiota, what it needs in order to survive, and what it produces in response to the host-stimuli provides important information about the role of gut microbes in intestinal homeostasis.

Elisa’s research is focused on the role of microbiota in host defence against opportunistic pathogens like Clostridium difficile and in intestinal chronic inflammatory diseases such as Crohn’s disease.

Her work is based on:

  • 16S rRNA community profiling and sequence-based metagenomic analysis of bacterial intestinal species in the human host
  • Study of gut microbiota carbohydrate utilization and by-products release in health, dysbiotic state or disease
  • Analysis of host cell inflammatory response to health- or disease-related intestinal commensal bacteria using in vitro and in vivo models of natural homeostatic or dysbiotic intestinal microbiota.

This research ultimately seeks to provide novel anti-microbials and bacteriotherapies in order to help the development of other therapeutic interventions to improve human health

Publications

  • Protective activity of the CnaBE3 domain conserved among Staphylococcus aureus Sdr proteins.

    Becherelli M, Prachi P, Viciani E, Biagini M, Fiaschi L et al.

    PloS one 2013;8;9;e74718

  • The ancillary protein 1 of Streptococcus pyogenes FCT-1 pili mediates cell adhesion and biofilm formation through heterophilic as well as homophilic interactions.

    Becherelli M, Manetti AG, Buccato S, Viciani E, Ciucchi L et al.

    Molecular microbiology 2012;83;5;1035-47

  • Paediatric obstructive sleep apnoea syndrome (OSAS) is associated with tonsil colonisation by Streptococcus pyogenes.

    Viciani E, Montagnani F, Tavarini S, Tordini G, Maccari S et al.

    Scientific reports 2016;6;20609

  • Prevalence of M75 Streptococcus pyogenes Strains Harboring slaA Gene in Patients Affected by Pediatric Obstructive Sleep Apnea Syndrome in Central Italy.

    Viciani E, Montagnani F, Tordini G, Romano A, Salerni L et al.

    Frontiers in microbiology 2017;8;294

  • Protective activity of the CnaBE3 domain conserved among Staphylococcus aureus Sdr proteins.

    Becherelli M, Prachi P, Viciani E, Biagini M, Fiaschi L et al.

    PloS one 2013;8;9;e74718

  • The ancillary protein 1 of Streptococcus pyogenes FCT-1 pili mediates cell adhesion and biofilm formation through heterophilic as well as homophilic interactions.

    Becherelli M, Manetti AG, Buccato S, Viciani E, Ciucchi L et al.

    Molecular microbiology 2012;83;5;1035-47

Viciani, Elisa
Elisa's Timeline
2015

Joined the Host-Microbiota Interactions team, Wellcome Trust Sanger Institute, UK

Awarded PhD in Life Sciences, Biology and Physiology of the Cell, University of Siena in collaboration with Novartis Vaccines, Italy

2011

Research Associate at Novartis Vaccines and Diagnostics, Italy

2010

Post-graduation Intern, Novartis Vaccines and Diagnostics, Italy

Awarded a MDs in Molecular Biology, University of Siena, Italy

2007

BSc in Biology awarded by the University of Siena, Italy