Dr Sarah Teichmann, FMedSci | Head of Cellular Genetics and Senior Group Leader

Sarah Teichmann is interested in global principles of protein interactions and gene expression . In particular, her research now focuses on genomics and immunity. From 2016, Sarah is the Head of Cellular Genetics at the Wellcome Trust Sanger Institute.

Sarah did her PhD at the MRC Laboratory of Molecular Biology, Cambridge, UK and was a Beit Memorial Fellow at University College London. She started a group at the MRC Laboratory of Molecular Biology in 2001. In 2013, she moved to the Wellcome Genome Campus in Hinxton, Cambridge, where her group was joint between the EMBL-European Bioinformatics Institute and the WT Sanger Institute. Sarah is an EMBO member and fellow of the Academy of Medical Sciences, and her work has been recognized by a number of prizes, including the Lister Prize, Biochemical Society Colworth Medal, Royal Society Crick Lecture and EMBO Gold Medal.

Publications

  • T cell fate and clonality inference from single-cell transcriptomes.

    Stubbington MJ, Lönnberg T, Proserpio V, Clare S, Speak AO et al.

    Nature methods 2016;13;4;329-32

  • Principles of assembly reveal a periodic table of protein complexes.

    Ahnert SE, Marsh JA, Hernández H, Robinson CV and Teichmann SA

    Science (New York, N.Y.) 2015;350;6266;aaa2245

  • Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation.

    Kolodziejczyk AA, Kim JK, Tsang JC, Ilicic T, Henriksson J et al.

    Cell stem cell 2015;17;4;471-85

  • Aging increases cell-to-cell transcriptional variability upon immune stimulation.

    Martinez-Jimenez CP, Eling N, Chen HC, Vallejos CA, Kolodziejczyk AA et al.

    Science (New York, N.Y.) 2017;355;6332;1433-1436

  • Are cells from a snowman realistic? Cryopreserved tissues as a source for single-cell RNA-sequencing experiments.

    Vieira Braga FA, Teichmann SA and Stubbington MJ

    Genome biology 2017;18;1;54

  • Power analysis of single-cell RNA-sequencing experiments.

    Svensson V, Natarajan KN, Ly LH, Miragaia RJ, Labalette C et al.

    Nature methods 2017

  • Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

    Lönnberg T, Svensson V, James KR, Fernandez-Ruiz D, Sebina I et al.

    Science immunology 2017;2;9

  • Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE.

    Wu YL, Stubbington MJ, Daly M, Teichmann SA and Rada C

    The Journal of experimental medicine 2017;214;1;183-196

  • Regulation, evolution and consequences of cotranslational protein complex assembly.

    Natan E, Wells JN, Teichmann SA and Marsh JA

    Current opinion in structural biology 2016;42;90-97

  • Single-cell analysis at the threshold.

    Chen X, Love JC, Navin NE, Pachter L, Stubbington MJ et al.

    Nature biotechnology 2016;34;11;1111-1118

  • Data on publications, structural analyzes, and queries used to build and utilize the AlloRep database

    Sousa,Filipa L., Parente,Daniel J., Hessman,Jacob A., Chazelle,Allen, Teichmann,Sarah A. and Swint-Kruse,Liskin;

    Data in Brief 2016;8;948–957

  • Single-cell RNA-seq identifies a PD-1(hi) ILC progenitor and defines its development pathway.

    Yu Y, Tsang JC, Wang C, Clare S, Wang J et al.

    Nature 2016;539;7627;102-106

  • MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.

    Eckersley-Maslin MA, Svensson V, Krueger C, Stubbs TM, Giehr P et al.

    Cell reports 2016;17;1;179-92

  • Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.

    Sousa FL, Parente DJ, Hessman JA, Chazelle A, Teichmann SA and Swint-Kruse L

    Data in brief 2016;8;948-57

  • Genetics and immunity in the era of single cell genomics.

    Vieira Braga FA, Teichmann SA and Chen X

    Human molecular genetics 2016

  • T cell fate and clonality inference from single-cell transcriptomes.

    Stubbington MJ, Lönnberg T, Proserpio V, Clare S, Speak AO et al.

    Nature methods 2016;13;4;329-32

  • Voices of biotech.

    Amit I, Baker D, Barker R, Berger B, Bertozzi C et al.

    Nature biotechnology 2016;34;3;270-5

  • AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription Regulators.

    Sousa FL, Parente DJ, Shis DL, Hessman JA, Chazelle A et al.

    Journal of molecular biology 2016;428;4;671-8

  • Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells.

    Macaulay IC, Svensson V, Labalette C, Ferreira L, Hamey F et al.

    Cell reports 2016;14;4;966-77

  • Principles of assembly reveal a periodic table of protein complexes.

    Ahnert SE, Marsh JA, Hernández H, Robinson CV and Teichmann SA

    Science (New York, N.Y.) 2015;350;6266;aaa2245

  • Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation.

    Kolodziejczyk AA, Kim JK, Tsang JC, Ilicic T, Henriksson J et al.

    Cell stem cell 2015;17;4;471-85

  • Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.

    Tsang JC, Yu Y, Burke S, Buettner F, Wang C et al.

    Genome biology 2015;16;178

  • Computational assignment of cell-cycle stage from single-cell transcriptome data.

    Scialdone A, Natarajan KN, Saraiva LR, Proserpio V, Teichmann SA et al.

    Methods (San Diego, Calif.) 2015;85;54-61

  • Structural and evolutionary versatility in protein complexes with uneven stoichiometry.

    Marsh JA, Rees HA, Ahnert SE and Teichmann SA

    Nature communications 2015;6;6394

  • Computational and analytical challenges in single-cell transcriptomics.

    Stegle O, Teichmann SA and Marioni JC

    Nature reviews. Genetics 2015;16;3;133-45

  • Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells.

    Buettner F, Natarajan KN, Casale FP, Proserpio V, Scialdone A et al.

    Nature biotechnology 2015;33;2;155-60

  • Structure, dynamics, assembly, and evolution of protein complexes.

    Marsh JA and Teichmann SA

    Annual review of biochemistry 2015;84;551-75

  • Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.

    Mahata B, Zhang X, Kolodziejczyk AA, Proserpio V, Haim-Vilmovsky L et al.

    Cell reports 2014;7;4;1130-42

  • Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.

    Marsh JA and Teichmann SA

    BioEssays : news and reviews in molecular, cellular and developmental biology 2014;36;2;209-18

Teichmann, Sarah
Sarah's Timeline
2016

Head of Cellular Genetics, Wellcome Trust Sanger Institute & Visiting Group Leader, EMBL-European Bioinformatics Institute

2015

Director of Research, Cavendish Laboratory/Physics Dept., Cambridge University

2013

Principal Research Associate, Cavendish Laboratory/Physics Dept., Cambridge University

Research Group Leader at EMBL-European Bioinformatics Institute & Senior Group Leader at the Wellcome Trust Sanger Institute

2006

MRC Programme Leader at the MRC Laboratory of Molecular Biology, Cambridge, UK

2005

Fellow, Trinity College, Cambridge

2001

MRC Career Track Programme Leader at the MRC Laboratory of Molecular Biology, Cambridge, UK & Research Fellow of Trinity College, Cambridge

2000

Postdoctoral research with Prof. Dame J. Thornton CBE FRS FMedSci in the Department of Biochemistry & Molecular Biology, University College London on a Beit Memorial Fellowship for Medical Research

Trinity College Research Fellowship

Awarded PhD, MRC Laboratory of Molecular Biology and Trinity College, Cambridge, in laboratory of Dr. C. Chothia FRS

1996

Awarded B.A. Biochemistry, Trinity College, Cambridge University