Loz Southam is a Senior Staff Scientist at the Wellcome Trust Sanger Institute where she aims to identify novel genetic variants that are associated with complex disease. Loz focuses on isolated populations in order to help discover rare and low frequency genetic variants that predispose individuals to common cardiometabolic diseases.
Using ancestry-informative markers to identify fine structure across 15 populations of European origin.
European journal of human genetics : EJHG 2014;22;10;1190-200
A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.
Nature communications 2014;5;4871
Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.
Nature communications 2014;5;5345
Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study.
Annals of human genetics 2013;77;3;268-74
A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.
Nature communications 2013;4;2872
Genome-wide meta-analysis of common variant differences between men and women.
Human molecular genetics 2012;21;21;4805-15
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
Lancet (London, England) 2012;380;9844;815-23
A variant in MCF2L is associated with osteoarthritis.
American journal of human genetics 2011;89;3;446-50
Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis.
BMC medical genetics 2009;10;141