Dr Leonor Sánchez Busó | Postdoctoral Fellow

Sánchez Busó, Leonor

Leonor Sánchez Busó is a Postdoctoral Fellow at the Pathogen Variation group. She is involved in the bioinformatic analysis of high-throughput sequencing data obtained from pathogenic microorganisms, mainly from the Neisseria genus. Her main interests are to unveil their mechanisms of genomic variation and evolution and how these relate to virulence and antibiotic resistance.

I recently started my first Postdoctoral position in the Pathogen Genomics group after a four-year PhD program in Spain. During this time I was involved in the research of microorganisms that pose a risk for public health, with special focus on the molecular epidemiology of the opportunistic pathogen Legionella pneumophila. This work introduced me both into the wet lab and the analysis of high-throughput sequencing data, in which I am now deeply interested in keeping involved.

My main Postdoctoral research is focused on the phylodynamic and phylogeographic genomic analysis of globally-distributed isolates from the Neisseria genus, with special interests in the sexually-transmitted Neisseria gonorrhoeae and the meningococcus-causing Neisseria meningitidis. My main research interests are to study the genomic mechanisms of variation related to virulence, antibiotic resistance and host-pathogen interaction.

Specifically, I am approaching these aims through the study of mechanisms of recombination, gene conversion for antigenic variation, phase variation, the role of restriction-modification systems, methylation patterns, etc. Results from these in silico analyses come from the integration of data from different sequencing platforms (Illumina, PacBio), which coupled with phenotypic data can provide relevant information about the biology and pathogenicity of the Neisseria genus.

Publications

  • Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.

    Sánchez-Busó L, Comas I, Jorques G and González-Candelas F

    Nature genetics 2014;46;11;1205-11

  • Geographical and Temporal Structures of Legionella pneumophila Sequence Types in Comunitat Valenciana (Spain), 1998 to 2013.

    Sánchez-Busó L, Coscollà M, Palero F, Camaró ML, Gimeno A et al.

    Applied and environmental microbiology 2015;81;20;7106-13

  • Phylogenetic analysis of environmental Legionella pneumophila isolates from an endemic area (Alcoy, Spain).

    Sánchez-Busó L, Olmos MP, Camaró ML, Adrián F, Calafat JM and González-Candelas F

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2015;30;45-54

  • Geographical and Temporal Structures of Legionella pneumophila Sequence Types in Comunitat Valenciana (Spain), 1998 to 2013.

    Sánchez-Busó L, Coscollà M, Palero F, Camaró ML, Gimeno A et al.

    Applied and environmental microbiology 2015;81;20;7106-13

  • Phylogenetic analysis of environmental Legionella pneumophila isolates from an endemic area (Alcoy, Spain).

    Sánchez-Busó L, Olmos MP, Camaró ML, Adrián F, Calafat JM and González-Candelas F

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2015;30;45-54

  • Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.

    Sánchez-Busó L, Comas I, Jorques G and González-Candelas F

    Nature genetics 2014;46;11;1205-11

  • [Molecular epidemiology studies on the immigrant population in Spain].

    González-Candelas F, Alma Bracho M, Comas I, d'Auria G, D Unková M et al.

    Revista española de salud pública 2014;88;6;819-28

  • Mixed infection by Legionella pneumophila in outbreak patients.

    Coscollá M, Fernández C, Colomina J, Sánchez-Busó L and González-Candelas F

    International journal of medical microbiology : IJMM 2014;304;3-4;307-13

Career/Research Highlights