Dr Leonor Sánchez Busó | Staff Scientist

Sánchez Busó, Leonor

Leonor Sánchez Busó is a Staff Scientist in the Infection Genomics group. She is involved in the bioinformatic analysis of high-throughput sequencing data obtained from pathogenic microorganisms, mainly from the Neisseria genus. Her main interests are to unveil their mechanisms of genomic variation and evolution and how these relate to virulence and antibiotic resistance.

I joined the Sanger Institute in 2015 as a Postdoctoral Fellow in the Infection Genomics group after a four-year PhD program in Spain and I enrolled in a Staff Scientist position in the same group in 2017. I understand high-quality research as a way of making an impact in science, which I believe I can achieve through my problem-solving skills but, most importantly, bringing together expertise through collaboration with different groups working in the field.

My PhD was focused in the research of microorganisms that pose a risk for public health, with special focus on the molecular epidemiology of the opportunistic pathogen Legionella pneumophila. This work introduced me into the analysis of high-throughput sequencing data, in which I am currently deeply involved.

My main postdoctoral research has been focused on the phylodynamic and phylogeographic genomic analysis of globally-distributed isolates from the Neisseria genus, with special interests in the sexually-transmitted Neisseria gonorrhoeae and the meningococcus-causing Neisseria meningitidis. My main research interests are to study its genomic epidemiology, mechanisms of variation related to virulence and antibiotic resistance. I am approaching these aims through the study of mechanisms of recombination, gene conversion for antigenic variation, phase variation, the role of restriction-modification systems, methylation patterns, etc. Results from these in silico analyses come from the integration of data from different sequencing platforms (Illumina, PacBio), which coupled with phenotypic data can provide relevant information about the biology and pathogenicity of the Neisseria genus.

Publications

  • Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.

    David S, Sánchez-Busó L, Harris SR, Marttinen P, Rusniok C et al.

    PLoS genetics 2017;13;6;e1006855

  • The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization.

    Unemo M, Golparian D, Sánchez-Busó L, Grad Y, Jacobsson S et al.

    The Journal of antimicrobial chemotherapy 2016;71;11;3096-3108

  • Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.

    Sánchez-Busó L, Comas I, Jorques G and González-Candelas F

    Nature genetics 2014;46;11;1205-11

  • ARIBA: rapid antimicrobial resistance genotyping directly from sequencing reads.

    Hunt M, Mather AE, Sánchez-Busó L, Page AJ, Parkhill J et al.

    Microbial genomics 2017;3;10;e000131

  • Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.

    David S, Sánchez-Busó L, Harris SR, Marttinen P, Rusniok C et al.

    PLoS genetics 2017;13;6;e1006855

  • European Chlamydia abortus livestock isolate genomes reveal unusual stability and limited diversity, reflected in geographical signatures.

    Seth-Smith HMB, Busó LS, Livingstone M, Sait M, Harris SR et al.

    BMC genomics 2017;18;1;344

  • Genomic epidemiology of a national outbreak of post-surgical<i>Mycobacterium abscessus</i>wound infections in Brazil.

    Everall I, Nogueira CL, Bryant JM, Sánchez-Busó L, Chimara E et al.

    Microbial genomics 2017;3;5;e000111

  • Bringing Treponema into the spotlight.

    Everall I and Sánchez-Busó L

    Nature reviews. Microbiology 2017;15;4;196

  • Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster.

    Arora N, Schuenemann VJ, Jäger G, Peltzer A, Seitz A et al.

    Nature microbiology 2016;2;16245

  • The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization.

    Unemo M, Golparian D, Sánchez-Busó L, Grad Y, Jacobsson S et al.

    The Journal of antimicrobial chemotherapy 2016;71;11;3096-3108

  • Linking an unchained malady.

    Sánchez-Busó L and Harris SR

    Nature reviews. Microbiology 2016;14;10;608

  • Geographical and Temporal Structures of Legionella pneumophila Sequence Types in Comunitat Valenciana (Spain), 1998 to 2013.

    Sánchez-Busó L, Coscollà M, Palero F, Camaró ML, Gimeno A et al.

    Applied and environmental microbiology 2015;81;20;7106-13

  • Phylogenetic analysis of environmental Legionella pneumophila isolates from an endemic area (Alcoy, Spain).

    Sánchez-Busó L, Olmos MP, Camaró ML, Adrián F, Calafat JM and González-Candelas F

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2015;30;45-54

  • Genomic Investigation of a Legionellosis Outbreak in a Persistently Colonized Hotel.

    Sánchez-Busó L, Guiral S, Crespi S, Moya V, Camaró ML et al.

    Frontiers in microbiology 2015;6;1556

  • [Molecular epidemiology studies on the immigrant population in Spain].

    González-Candelas F, Alma Bracho M, Comas I, d'Auria G, D Unková M et al.

    Revista espanola de salud publica 2014;88;6;819-28

  • Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.

    Sánchez-Busó L, Comas I, Jorques G and González-Candelas F

    Nature genetics 2014;46;11;1205-11

  • Mixed infection by Legionella pneumophila in outbreak patients.

    Coscollá M, Fernández C, Colomina J, Sánchez-Busó L and González-Candelas F

    International journal of medical microbiology : IJMM 2014;304;3-4;307-13

  • Genetic Characterization of Legionella pneumophila Isolated from a Common Watershed in Comunidad Valenciana, Spain.

    Sánchez-Busó L, Coscollá M, Pinto-Carbó M, Catalán V and González-Candelas F

    PloS one 2013;8;4;e61564

Career/Research Highlights

Sánchez Busó, Leonor
Leonor's Timeline
2017

Staff Scientist, Wellcome Sanger Institute (Infection Genomics Programme), UK

2015

Postdoctoral Fellow, Wellcome Trust Sanger Institute (Infection Genomics Programme), UK

PhD in Biotechnology, Polytechnic University of Valencia, Spain

2014

Visiting PhD student at the Wellcome Trust Sanger Institute (Pathogen Genomics), UK

2010

MSc in Biomedical Biotechnology, Polytechnic University of Valencia, Spain

2009

BSc in Biotechnology, Polytechnic University of Valencia, Spain