Dr Gabriele Rinck | Project Manager

Rinck, Gabriele

Project Manager for the Prenatal Assessment of Genomes and Exomes (PAGE) study. The PAGE study analyses the genetic information of babies and parents where structural abnormalities were detected during pregnancy.

As a Project Manager I am responsible for the day-to-day management of the PAGE study, co-ordinating the different parts of the study to ensure that the project is progressing and running smoothly.

Experts from research centres, NHS fetal medicine units, diagnostic laboratories and a patient support charity are collaborating in our study, forming the PAGE consortium. This consortium consists of teams from the Wellcome Trust Sanger Institute, Great Ormond Street Hospital (London), Birmingham Women's Hospital, Ethox Centre (Oxford), the University of Birmingham, the University of Cambridge and the charity ARC (Antenatal Results and Choices). Here at the Sanger Institute we will analyse samples from 1000 families in order to gain a better understanding of genetic variants causing developmental problems during pregnancies. The ultimate aim is to improve prenatal diagnostics and parental counselling in the future.

Before joining the Sanger Institute I worked for over ten years in the diagnostic industry. Initially, my research in virology and antiviral drug resistance sparked my interest for personalised medicine, providing specific diagnostics which may allow more effective bespoke therapies for patients. My work involved projects in the area of pharmacogenetics, companion diagnostics, genetic testing and project management of analytical studies for clinical trials.

Publications

  • Osteoradionecrosis in head-and-neck cancer has a distinct genotype-dependent cause.

    Lyons AJ, West CM, Risk JM, Slevin NJ, Chan C et al.

    International journal of radiation oncology, biology, physics 2012;82;4;1479-84

  • Implications for HIV testing policy derived from combining data on voluntary confidential testing with viral sequences and serological analyses.

    Brown AE, Murphy G, Rinck G, Clewley JP, Hill C et al.

    Sexually transmitted infections 2009;85;1;4-9

  • Cell-derived sequences in the N-terminal region of the polyprotein of a cytopathogenic pestivirus.

    Müller A, Rinck G, Thiel HJ and Tautz N

    Journal of virology 2003;77;19;10663-9

  • Persistent and transient replication of full-length hepatitis C virus genomes in cell culture.

    Pietschmann T, Lohmann V, Kaul A, Krieger N, Rinck G et al.

    Journal of virology 2002;76;8;4008-21

  • A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus.

    Rinck G, Birghan C, Harada T, Meyers G, Thiel HJ and Tautz N

    Journal of virology 2001;75;19;9470-82

  • Establishment and characterization of cytopathogenic and noncytopathogenic pestivirus replicons.

    Tautz N, Harada T, Kaiser A, Rinck G, Behrens S and Thiel HJ

    Journal of virology 1999;73;11;9422-32

Rinck, Gabriele
Gabriele's Timeline
2015

Sanger Institute: Project Manager for the PAGE study

2012

Lab21 Ltd, Cambridge: Head of Clinical Trials - managing analytical work for Clinical Trials.

2010

Lab21 Ltd, Cambridge: Head of Molecular Diagnostics & Pharma Services

2008

Lab21 Ltd, Cambridge: Head of Molecular Diagnostics Development

2005

Lab21 Ltd, Cambridge: Senior Development Scientist - Diagnostics in the area of Virology, Genetics & Pharmacogenetics

2003

Health Protection Agency, Colindale: Clinical Scientist - HIV Drug Resistance

2002

Visible Genetics UK, Cambridge: Senior Scientist - HCV Diagnostics

University of Gießen, Germany: PhD in Virology / Molecular Biology

2001

Virco UK, Cambridge: Senior Scientist - HCV Diagnostics