Dr Haydn Prosser | Senior Staff Scientist

Prosser, Haydn

I have developed a resource of micro RNA knockouts in murine embryonic stem cells which is publicly available from the repositories EuMMCR at Munich, and MMRRC at UC Davis USA.

I am also involved in chromosomal engineering; having developed methods for site specific transgenesis I am currently applying similar techniques to humanize mouse genetic loci.

Publications

  • Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.

    Wong SF, Agarwal V, Mansfield JH, Denans N, Schwartz MG et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;35;E4884-93

  • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

    White K, Lu Y, Annis S, Hale AE, Chau BN et al.

    EMBO molecular medicine 2015;7;6;695-713

  • MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.

    Mok Y, Schwierzeck V, Thomas DC, Vigorito E, Rayner TF et al.

    Journal of immunology (Baltimore, Md. : 1950) 2013;191;6;3037-3048

  • ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing.

    Royo H, Prosser H, Ruzankina Y, Mahadevaiah SK, Cloutier JM et al.

    Genes & development 2013;27;13;1484-94

  • Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.

    Zhang DS, Piazza V, Perrin BJ, Rzadzinska AK, Poczatek JC et al.

    Nature 2012;481;7382;520-4

  • A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

    Prosser HM, Koike-Yusa H, Cooper JD, Law FC and Bradley A

    Nature biotechnology 2011;29;9;840-5

  • Evidence that meiotic sex chromosome inactivation is essential for male fertility.

    Royo H, Polikiewicz G, Mahadevaiah SK, Prosser H, Mitchell M et al.

    Current biology : CB 2010;20;23;2117-23

  • An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

    Pardo M, Lang B, Yu L, Prosser H, Bradley A et al.

    Cell stem cell 2010;6;4;382-95

  • Agouti C57BL/6N embryonic stem cells for mouse genetic resources.

    Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM et al.

    Nature methods 2009;6;7;493-5

  • A DNA transposon-based approach to validate oncogenic mutations in the mouse.

    Su Q, Prosser HM, Campos LS, Ortiz M, Nakamura T et al.

    Proceedings of the National Academy of Sciences of the United States of America 2008;105;50;19904-9

  • Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.

    Prosser HM, Rzadzinska AK, Steel KP and Bradley A

    Molecular and cellular biology 2008;28;5;1702-12

  • Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.

    Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH and Maywood ES

    Proceedings of the National Academy of Sciences of the United States of America 2007;104;2;648-53

Prosser, Haydn
Haydn's Timeline
2002

Senior Staff Scientist at Wellcome Trust Sanger Institute

1997

Senior investigator in Comparative Genetics at GlaxoSmithKline Pharmaceuticals

1991

Postdoctoral research in molecular immunology at Massachusetts Institute of Technology

1987

Ph.D in Molecular Immunology of T cells at The Imperial Cancer Research Fund, London