Hannes uses computational and statistical methods to support studies dissecting the molecular basis of cancers and other diseases.
Together with wet lab scientists Hannes currently works mainly on genetic screens using CRISPR/Cas9 technology. He also writes software and is the author of the SMALT aligner for DNA sequencing reads.
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis.
Cell reports 2015;10;8;1239-45
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.
Nature genetics 2015;47;1;47-56
Systematic evaluation of spliced alignment programs for RNA-seq data.
Nature methods 2013;10;12;1185-91
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
Cancer cell 2013;24;1;15-29
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.
Nature genetics 2008;40;10;1163-5