I am a third year PhD student, jointly supervised by Paul Kellam and Carl Anderson. I am using immune repertoire sequencing to characterise adaptive immune responses to virus challenge. I am interested in studying the relationship between virus infection and host susceptibility to autoimmune disease.
My current research interests fit at the interface between infectious diseases and immunology. Being co-supervised by members of two different faculties gives me the opportunity to work on a very interdisciplinary project, investigating complex patterns of host-pathogen interaction. My work as a PhD student so far has been focused on the development of methods for error-correctable amplification and sequencing of immune receptor repertoires. Over the next few years, I will use these methods to investigate the immunological footprint of infection with lymphotropic viruses and their long-term effects on immune memory.
My previous work as a Placement student in Paul Kellam's team was based on developing methodologies for full-genome sequencing of diverse RNA viruses and applying these methods to understand the genetic diversity and evolution of Norovirus from a large outbreak study in Ho Chi Minh, Vietnam.
As an undergraduate student at the University of Bristol, I worked with Dr. David Matthews on the characterisation of transcriptomic and proteomic changes occurring in response to Adenovirus infection, using the PIT analysis developed in his group.
Deep sequencing of norovirus genomes defines evolutionary patterns in an urban tropical setting.
Journal of virology 2014;88;19;11056-69
Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.
PloS one 2014;9;10;e108384
Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus.
Emerging infectious diseases 2013;19;5;736-42B
Genome watch: The chronicles of virus-host affairs.
Nature reviews. Microbiology 2015;13;8;460