Charles Mulamba | Staff Scientist

Mulamba, Charles

Charles is a Medical Laboratory Scientist with keen interests in Medical Parasitology and Molecular Entomology.

My current research focuses on mapping genetic variation associated with mosquito susceptibility to P. falciparum. This work includes collecting wild Anopheles species and exposing them to field strains of P. falciparum. Genome-wide association studies (GWAS) will then be used to identify genetic variation associated with significant impacts on the outcome of mosquito infection with malaria parasites. Understanding the molecular basis of vector–parasite interactions is particularly important for designing and implementing alternative malaria control methods.

Prior to my appointment at WTSI, I have characterised the extent and mechanisms of insecticide resistance mainly in the malaria vector Anopheles funestus across Africa. Part of this work has influenced the recent shift to the use of carbamates for indoor spraying programs across Uganda. I have also been involved in laboratory systems’ strengthening for malaria diagnosis and neglected tropical disease control in low income countries particularly in Uganda, Kenya, DRC, Malawi, Ghana and Sri Lanka.

Publications

  • Widespread pyrethroid and DDT resistance in the major malaria vector Anopheles funestus in East Africa is driven by metabolic resistance mechanisms.

    Mulamba C, Riveron JM, Ibrahim SS, Irving H, Barnes KG et al.

    PloS one 2014;9;10;e110058

  • Contrasting Plasmodium infection rates and insecticide susceptibility profiles between the sympatric sibling species Anopheles parensis and Anopheles funestus s.s: a potential challenge for malaria vector control in Uganda.

    Mulamba C, Irving H, Riveron JM, Mukwaya LG, Birungi J and Wondji CS

    Parasites & vectors 2014;7;71

Mulamba, Charles
Charles's Timeline
2015

Joined the WTSI

2013

Laboratory Systems Specialist/ Post-graduate Research Assistant (Liverpool School of Tropical Medicine)

2011

Began MSc at University of Liverpool, School of Tropical Medicine (with Charles Wondji)

2010

Awarded a Wellcome Trust Masters’ Training Fellowship

2009

Medical Laboratory Scientist (Mbarara University Regional Referral Hospital (U))