Charles is a Medical Laboratory Scientist with keen interests in Medical Parasitology and Molecular Entomology.
My current research focuses on mapping genetic variation associated with mosquito susceptibility to P. falciparum. This work includes collecting wild Anopheles species and exposing them to field strains of P. falciparum. Genome-wide association studies (GWAS) will then be used to identify genetic variation associated with significant impacts on the outcome of mosquito infection with malaria parasites. Understanding the molecular basis of vector–parasite interactions is particularly important for designing and implementing alternative malaria control methods.
Prior to my appointment at WTSI, I have characterised the extent and mechanisms of insecticide resistance mainly in the malaria vector Anopheles funestus across Africa. Part of this work has influenced the recent shift to the use of carbamates for indoor spraying programs across Uganda. I have also been involved in laboratory systems’ strengthening for malaria diagnosis and neglected tropical disease control in low income countries particularly in Uganda, Kenya, DRC, Malawi, Ghana and Sri Lanka.
Widespread pyrethroid and DDT resistance in the major malaria vector Anopheles funestus in East Africa is driven by metabolic resistance mechanisms.
PloS one 2014;9;10;e110058
Contrasting Plasmodium infection rates and insecticide susceptibility profiles between the sympatric sibling species Anopheles parensis and Anopheles funestus s.s: a potential challenge for malaria vector control in Uganda.
Parasites & vectors 2014;7;71