Dr Danesh Moradigaravand | Senior Bioinformatician

Moradigaravand, Danesh

I am an evolutionary biologist and genomic data scientist, broadly interested in the epidemiology and population genomics of major pathogens, particularly in the context of the dissemination and emergence of antimicrobial resistance. Furthermore, I developed mathematical and simulation frameworks to elucidate complex evolutionary dynamics of microbial populations during adaptation and the impact of recombination on adaptation.

Publications

  • The dissemination of multidrug-resistant Enterobacter cloacae throughout the UK and Ireland.

    Moradigaravand D, Reuter S, Martin V, Peacock SJ and Parkhill J

    Nature microbiology 2016;1;16173

  • Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland.

    Moradigaravand D, Boinett CJ, Martin V, Peacock SJ and Parkhill J

    Genome research 2016;26;8;1101-9

  • Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland.

    Moradigaravand D, Martin V, Peacock SJ and Parkhill J

    mBio 2017;8;1

  • Evolution of the Staphylococcus argenteus ST2250 Clone in Northeastern Thailand Is Linked with the Acquisition of Livestock-Associated Staphylococcal Genes.

    Moradigaravand D, Jamrozy D, Mostowy R, Anderson A, Nickerson EK et al.

    mBio 2017;8;4

  • The evolution of natural competence: disentangling costs and benefits of sex in bacteria.

    Moradigaravand D and Engelstädter J

    The American naturalist 2013;182;4;E112-26

  • Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1.

    Moradigaravand D, Kouyos R, Hinkley T, Haddad M, Petropoulos CJ et al.

    PLoS genetics 2014;10;6;e1004439

  • The effect of bacterial recombination on adaptation on fitness landscapes with limited peak accessibility.

    Moradigaravand D and Engelstädter J

    PLoS computational biology 2012;8;10;e1002735

  • The impact of natural transformation on adaptation in spatially structured bacterial populations.

    Moradigaravand D and Engelstädter J

    BMC evolutionary biology 2014;14;141

  • Population structure of multidrug resistant Klebsiella oxytoca within hospitals across the UK and Ireland identifies sharing of virulence and resistance genes with K. pneumoniae.

    Moradigaravand D, Martin V, Peacock SJ and Parkhill J

    Genome biology and evolution 2017

  • Whole genome sequencing reveals high-resolution epidemiological links between clinical and environmental Klebsiella pneumoniae.

    Runcharoen C, Moradigaravand D, Blane B, Paksanont S, Thammachote J et al.

    Genome medicine 2017;9;1;6

Moradigaravand, Danesh