Daniel Mead | 25th Anniversary Sequencing Project Coordinator

Mead, Dan

Daniel works for the Directors' office running the 25th Anniversary Sequencing Project. The Sanger Institute is turning 25 in 2018 and as part of this Daniel is coordinating the sequencing of 25 novel genomes.

I joined the Directors' office in May 2017, working closely with Drs Wilson and Rayner, to deliver 25 novel genomes for public release. This will be in partnership with the Natural History Museum (amongst others) and will be focussed on aspects celebrating UK biodiversity.

Before this I worked in the PMO from October 2016 and strived to take a professional, proactive, positive, resilient, resourceful and tenacious approach to ensure success; working to get agreement from project team members at all levels of the Institute, demonstrating transparent progress and the delivery of projects.

Previously I worked on a number of projects; co-ordinating the data collection and distribution, maintaining an overview of the QC and analysis and the editing of related manuscripts. These projects are large collaborations involving up to eight different institutes based in six countries, as well as departments within the WTSI. The main projects were:

  • INTERVAL/UKBB. Investigating blood phenotype/genotype correlations in a 550,000 sample UK cohort.
  • Blueprint WP10. Broad spectrum epigenomics of three human blood cell types.

Previous to this role I worked as an advanced research assistant in the Kwiatkowski group, which was split between being focused on sample processing, management of the lab and delivery of the results to collaborators. Projects I have contributed to included:

  • TRAC. Tracking artemisinin resistance in plasmodium (malaria) parasites
  • MalariaGen genomic epidemiology network
    • Anopheles 100 genomes project
    • Human genetic variation in malaria endemic countries

Before joining the WTSI in 2008 I worked as a forensic DNA analyst at the now defunct government agency the Forensic Science Service, helping to DNA profile thousands of suspected criminals.

Publications

  • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

    Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D et al.

    Cell 2016;167;5;1415-1429.e19

  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

    Chen L, Ge B, Casale FP, Vasquez L, Kwan T et al.

    Cell 2016;167;5;1398-1414.e24

  • An interactive genome browser of association results from the UK10K cohorts project.

    Geihs M, Yan Y, Walter K, Huang J, Memari Y et al.

    Bioinformatics (Oxford, England) 2015;31;24;4029-31

  • Optimized whole-genome amplification strategy for extremely AT-biased template.

    Oyola SO, Manske M, Campino S, Claessens A, Hamilton WL et al.

    DNA research : an international journal for rapid publication of reports on genes and genomes 2014;21;6;661-71

  • Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.

    Ocholla H, Preston MD, Mipando M, Jensen AT, Campino S et al.

    The Journal of infectious diseases 2014;210;12;1991-2000

  • K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

    Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D et al.

    The Journal of infectious diseases 2015;211;8;1352-5

  • Imputation-based meta-analysis of severe malaria in three African populations.

    Band G, Le QS, Jostins L, Pirinen M, Kivinen K et al.

    PLoS genetics 2013;9;5;e1003509

  • Genome-wide and fine-resolution association analysis of malaria in West Africa.

    Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P et al.

    Nature genetics 2009;41;6;657-65

  • Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.

    Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S et al.

    Nature genetics 2013;45;6;648-55

  • Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J et al.

    Nature genetics 2015;47;3;226-34

  • A novel locus of resistance to severe malaria in a region of ancient balancing selection.

    Malaria Genomic Epidemiology Network, Band G, Rockett KA, Spencer CC and Kwiatkowski DP

    Nature 2015;526;7572;253-7

  • Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

    Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J et al.

    Nature 2012;487;7407;375-9

  • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

    Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D et al.

    Cell 2016;167;5;1415-1429.e19

  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

    Chen L, Ge B, Casale FP, Vasquez L, Kwan T et al.

    Cell 2016;167;5;1398-1414.e24

  • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.

    Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C et al.

    Nature genetics 2016;48;11;1303-1312

  • Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum.

    Miles A, Iqbal Z, Vauterin P, Pearson R, Campino S et al.

    Genome research 2016;26;9;1288-99

  • Genomic analysis of local variation and recent evolution in Plasmodium vivax.

    Pearson RD, Amato R, Auburn S, Miotto O, Almagro-Garcia J et al.

    Nature genetics 2016;48;8;959-964

  • An interactive genome browser of association results from the UK10K cohorts project.

    Geihs M, Yan Y, Walter K, Huang J, Memari Y et al.

    Bioinformatics (Oxford, England) 2015;31;24;4029-31

  • Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae.

    Redmond SN, Eiglmeier K, Mitri C, Markianos K, Guelbeogo WM et al.

    BMC genomics 2015;16;779

  • A novel locus of resistance to severe malaria in a region of ancient balancing selection.

    Malaria Genomic Epidemiology Network, Band G, Rockett KA, Spencer CC and Kwiatkowski DP

    Nature 2015;526;7572;253-7

  • K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

    Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D et al.

    The Journal of infectious diseases 2015;211;8;1352-5

  • Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J et al.

    Nature genetics 2015;47;3;226-34

  • Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.

    Ocholla H, Preston MD, Mipando M, Jensen AT, Campino S et al.

    The Journal of infectious diseases 2014;210;12;1991-2000

  • Optimized whole-genome amplification strategy for extremely AT-biased template.

    Oyola SO, Manske M, Campino S, Claessens A, Hamilton WL et al.

    DNA research : an international journal for rapid publication of reports on genes and genomes 2014;21;6;661-71

  • A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.

    Wendler JP, Okombo J, Amato R, Miotto O, Kiara SM et al.

    PloS one 2014;9;5;e96486

  • Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.

    Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S et al.

    Nature genetics 2013;45;6;648-55

  • Imputation-based meta-analysis of severe malaria in three African populations.

    Band G, Le QS, Jostins L, Pirinen M, Kivinen K et al.

    PLoS genetics 2013;9;5;e1003509

  • Efficient depletion of host DNA contamination in malaria clinical sequencing.

    Oyola SO, Gu Y, Manske M, Otto TD, O'Brien J et al.

    Journal of clinical microbiology 2013;51;3;745-51

  • Effective preparation of Plasmodium vivax field isolates for high-throughput whole genome sequencing.

    Auburn S, Marfurt J, Maslen G, Campino S, Ruano Rubio V et al.

    PloS one 2013;8;1;e53160

  • Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

    Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J et al.

    Nature 2012;487;7407;375-9

  • Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.

    Auburn S, Campino S, Miotto O, Djimde AA, Zongo I et al.

    PloS one 2012;7;2;e32891

  • An effective method to purify Plasmodium falciparum DNA directly from clinical blood samples for whole genome high-throughput sequencing.

    Auburn S, Campino S, Clark TG, Djimde AA, Zongo I et al.

    PloS one 2011;6;7;e22213

  • Genome-wide and fine-resolution association analysis of malaria in West Africa.

    Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P et al.

    Nature genetics 2009;41;6;657-65

  • A global network for investigating the genomic epidemiology of malaria.

    Malaria Genomic Epidemiology Network

    Nature 2008;456;7223;732-7

Mead, Dan
Daniel's Timeline
2017

Appointed to 25th Anniversary Seq. Coordinator position

2016

Joined PMO

2014

Joined Soranzo Group

2008

Joined Kwiatkowski Goup