Marin Menendez, Alejandro
My research focus on investigating the functional impact of human genetic factors that confer protection against severe malaria. Aiming to unravel specific host-pathogen interactions from both sides, parasite and red blood cell, I am generating parasite mutant lines using the CRISPR-Cas9 system and characterizing the red blood cell membrane by flow cytometry and mass spectrometry. These complementary approaches will further characterize which of those interplays are essential for invasion to occur and help develop more efficient tools to tackle malaria infections.
Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin.
Scientific reports 2017;7;41242
Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia.
PLoS neglected tropical diseases 2013;7;4;e2155
A family of cyclophilin-like molecular chaperones in Plasmodium falciparum.
Molecular and biochemical parasitology 2012;184;1;44-7
Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum.
Protein expression and purification 2011;78;2;225-34
Susceptibility of Plasmodium falciparum to glutamate dehydrogenase inhibitors--a possible new antimalarial target.
Molecular and biochemical parasitology 2010;172;2;152-5