Mouse genomes are known to contain a dozen highly polymorphic complex loci such as the major urinary proteins (MUPs), Immunity related GTPases (IRGs) and MHC. At the moment, their structure cannot be resolved. As a part of Sanger mouse genomes project, we are performing a targeted reassembly of these loci.
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse.
Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
Cell host & microbe 2014;15;2;132-8
The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes.
Mammalian genome : official journal of the International Mammalian Genome Society 2015;26;9-10;403-12