Dr Trevor Lawley | Group Leader

Lawley, Trevor

Trevor's research investigates the mechanisms that underlie how micro-organisms on mucosal surfaces (gut, nasopharnyx, uro-gential tract) interact with their host during periods of health and disease. In particular he seeks to develop novel ways to treat diseases that are associated with unwanted imbalances in the micro-organism communities.

Trevor uses high-throughput genome sequencing to investigate the microbial communities contained on and within host organisms that are associated with health and disease. He uses clinical samples and mouse models to identify the pathogen and host factors that are linked to disease and infectivity.

Trevor obtained his PhD from the University of Alberta, Canada, where he studied the mechanisms that pathogenic bacteria use to disseminate antibiotic resistance genes. Dr Diane Taylor and Dr Laura Frost were his supervisors. His PhD thesis culminated in 2004 with him receiving the 'Gold Award' (Graduate Student of the Year) from the Canadian Society of Microbiologists.

After his PhD Trevor was awarded a Canadian Institutes of Health Research post-doctoral fellowship to work in the Laboratory of Professor Stanley Falkow and Dr Denise Monack at Stanford University, USA, where he studied the impact of antibiotic treatment on Salmonella disease and transmission. In 2007 Trevor received a Royal Society of London Award - sponsored by Professor Gordon Dougan - to start a research programme on Clostridium difficile disease and transmission within the Microbial Pathogenesis group at the Wellcome Trust Sanger Institute.

In 2010, Trevor was appointed as a Career Development Fellow in the Sanger Institute Faculty and was promoted to Group Leader in 2014. He receives funding from the Medical Research Council.

Publications

  • Systematic discovery of probiotics.

    Forster SC and Lawley TD

    Nature biotechnology 2015;33;1;47-9

  • Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011.

    Knetsch CW, Connor TR, Mutreja A, van Dorp SM, Sanders IM et al.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2014;19;45;20954

  • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

    Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD et al.

    Cell host & microbe 2014;16;4;504-16

  • Emerging insights on intestinal dysbiosis during bacterial infections.

    Pham TA and Lawley TD

    Current opinion in microbiology 2014;17;67-74

  • Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.

    Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP et al.

    BMC genomics 2014;15;160

  • Bacteriotherapy for the treatment of intestinal dysbiosis caused by Clostridium difficile infection.

    Adamu BO and Lawley TD

    Current opinion in microbiology 2013;16;5;596-601

  • Current application and future perspectives of molecular typing methods to study Clostridium difficile infections.

    Knetsch CW, Lawley TD, Hensgens MP, Corver J, Wilcox MW and Kuijper EJ

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2013;18;4;20381

  • Intestinal colonization resistance.

    Lawley TD and Walker AW

    Immunology 2013;138;1;1-11

  • Emergence and global spread of epidemic healthcare-associated Clostridium difficile.

    He M, Miyajima F, Roberts P, Ellison L, Pickard DJ et al.

    Nature genetics 2013;45;1;109-13

  • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.

    No authors listed

    PLoS pathogens 2012;8;10;e1002995

  • Transmission of the gut microbiota: spreading of health.

    Browne HP, Neville BA, Forster SC and Lawley TD

    Nature reviews. Microbiology 2017

  • Comparative genome analysis and global phylogeny of the toxin variant Clostridium difficile PCR Ribotype 017 reveals the evolution of two independent sub-lineages.

    Cairns MD, Preston MD, Hall CL, Gerding DN, Hawkey PM et al.

    Journal of clinical microbiology 2016

  • Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.

    Browne HP, Forster SC, Anonye BO, Kumar N, Neville BA et al.

    Nature 2016;533;7604;543-6

  • Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes.

    O Sheridan P, Martin JC, Lawley TD, Browne HP, Harris HM et al.

    Microbial genomics 2016;2;2;e000043

  • HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes.

    Forster SC, Browne HP, Kumar N, Hunt M, Denise H et al.

    Nucleic acids research 2016;44;D1;D604-9

  • Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.

    Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C et al.

    Infection and immunity 2016;84;3;856-65

  • Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial-Microbiota Interface.

    Schreiber F, Arasteh JM and Lawley TD

    Journal of molecular biology 2015;427;23;3676-82

  • Genomic Epidemiology of a Protracted Hospital Outbreak Caused by a Toxin A-Negative Clostridium difficile Sublineage PCR Ribotype 017 Strain in London, England.

    Cairns MD, Preston MD, Lawley TD, Clark TG, Stabler RA and Wren BW

    Journal of clinical microbiology 2015;53;10;3141-7

  • Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.

    Carter GP, Chakravorty A, Pham Nguyen TA, Mileto S, Schreiber F et al.

    mBio 2015;6;3;e00551

  • As Clear as Mud? Determining the Diversity and Prevalence of Prophages in the Draft Genomes of Estuarine Isolates of Clostridium difficile.

    Hargreaves KR, Otieno JR, Thanki A, Blades MJ, Millard AD et al.

    Genome biology and evolution 2015;7;7;1842-55

  • Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci.

    Couchman EC, Browne HP, Dunn M, Lawley TD, Songer JG et al.

    BMC genomics 2015;16;392

  • Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

    Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D et al.

    Immunity 2015;42;4;744-55

  • Emergence of an outbreak-associated Clostridium difficile variant with increased virulence.

    Quesada-Gómez C, López-Ureña D, Acuña-Amador L, Villalobos-Zúñiga M, Du T et al.

    Journal of clinical microbiology 2015;53;4;1216-26

  • High-throughput analysis of gene essentiality and sporulation in Clostridium difficile.

    Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M et al.

    mBio 2015;6;2;e02383

  • A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity.

    Gebhart D, Lok S, Clare S, Tomas M, Stares M et al.

    mBio 2015;6;2

  • Complete genome sequence of BS49 and draft genome sequence of BS34A, Bacillus subtilis strains carrying Tn916.

    Browne HP, Anvar SY, Frank J, Lawley TD, Roberts AP and Smits WK

    FEMS microbiology letters 2015;362;3;1-4

  • Systematic discovery of probiotics.

    Forster SC and Lawley TD

    Nature biotechnology 2015;33;1;47-9

  • Pathogens' exploitation of the intestinal food web.

    Pham N TA and Lawley TD

    Cell host & microbe 2014;16;6;703-5

  • Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011.

    Knetsch CW, Connor TR, Mutreja A, van Dorp SM, Sanders IM et al.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2014;19;45;20954

  • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

    Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD et al.

    Cell host & microbe 2014;16;4;504-16

  • Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

    Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G et al.

    Cell host & microbe 2014;15;4;471-83

  • Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.

    Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP et al.

    BMC genomics 2014;15;160

  • Emerging insights on intestinal dysbiosis during bacterial infections.

    Pham TA and Lawley TD

    Current opinion in microbiology 2014;17;67-74

  • Abundant and diverse clustered regularly interspaced short palindromic repeat spacers in Clostridium difficile strains and prophages target multiple phage types within this pathogen.

    Hargreaves KR, Flores CO, Lawley TD and Clokie MR

    mBio 2014;5;5;e01045-13

  • Bacteriotherapy for the treatment of intestinal dysbiosis caused by Clostridium difficile infection.

    Adamu BO and Lawley TD

    Current opinion in microbiology 2013;16;5;596-601

  • The agr locus regulates virulence and colonization genes in Clostridium difficile 027.

    Martin MJ, Clare S, Goulding D, Faulds-Pain A, Barquist L et al.

    Journal of bacteriology 2013;195;16;3672-81

  • Proteomic comparison of historic and recently emerged hypervirulent Clostridium difficile strains.

    Chen JW, Scaria J, Mao C, Sobral B, Zhang S et al.

    Journal of proteome research 2013;12;3;1151-61

  • SpoIVA and SipL are Clostridium difficile spore morphogenetic proteins.

    Nock AM, Lawley TD and Shen A

    Journal of bacteriology 2013;195;6;1214-25

  • Therapeutic modulation of intestinal dysbiosis.

    Walker AW and Lawley TD

    Pharmacological research 2013;69;1;75-86

  • Current application and future perspectives of molecular typing methods to study Clostridium difficile infections.

    Knetsch CW, Lawley TD, Hensgens MP, Corver J, Wilcox MW and Kuijper EJ

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2013;18;4;20381

  • Emergence and global spread of epidemic healthcare-associated Clostridium difficile.

    He M, Miyajima F, Roberts P, Ellison L, Pickard DJ et al.

    Nature genetics 2013;45;1;109-13

  • Global analysis of the sporulation pathway of Clostridium difficile.

    Fimlaid KA, Bond JP, Schutz KC, Putnam EE, Leung JM et al.

    PLoS genetics 2013;9;8;e1003660

  • Intestinal colonization resistance.

    Lawley TD and Walker AW

    Immunology 2013;138;1;1-11

  • The Clostridium difficile spo0A gene is a persistence and transmission factor.

    Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ et al.

    Infection and immunity 2012;80;8;2704-11

  • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.

    No authors listed

    PLoS pathogens 2012;8;10;e1002995

  • Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens.

    Lawley TD, Clare S, Deakin LJ, Goulding D, Yen JL et al.

    Applied and environmental microbiology 2010;76;20;6895-900

  • Evolutionary dynamics of Clostridium difficile over short and long time scales.

    He M, Sebaihia M, Lawley TD, Stabler RA, Dawson LF et al.

    Proceedings of the National Academy of Sciences of the United States of America 2010;107;16;7527-32

  • Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts.

    Lawley TD, Clare S, Walker AW, Goulding D, Stabler RA et al.

    Infection and immunity 2009;77;9;3661-9

  • Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.

    Lawley TD, Croucher NJ, Yu L, Clare S, Sebaihia M et al.

    Journal of bacteriology 2009;191;17;5377-86

  • Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium.

    Stabler RA, He M, Dawson L, Martin M, Valiente E et al.

    Genome biology 2009;10;9;R102

  • Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse.

    Lawley TD, Chan K, Thompson LJ, Kim CC, Govoni GR and Monack DM

    PLoS pathogens 2006;2;2;e11

Lawley, Trevor