Dr Kerstin Howe | Senior Scientific Manager

Howe, Kerstin

I am a computational biologist whose primary interest is in the provision of accurate reference genome sequences and structures to support biological, agricultural and clinical science.

My original background is in molecular biology. After gaining my first degree at Ruhr-Universitaet Bochum, Germany, I worked as a project manager for a chemical laboratory for a year, before returning to university to obtain a PhD in fungal genetics.

I joined the Sanger Institute in 2000, and initially worked as a computational biologist on the annotation efforts for the human, zebrafish and C. elegans genomes. In 2003, I was appointed to lead the team responsible for producing and annotating the zebrafish reference genome assembly. Since 2007, my team has represented the Sanger Institute's involvement in the Genome Reference Consortium. We are responsible for the reference genome assemblies of human, mouse and zebrafish, and are also involved in the analysis and correction of several other genomes.

Publications

  • Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly.

    Schneider VA, Graves-Lindsay T, Howe K, Bouk N, Chen HC et al.

    Genome research 2017;27;5;849-864

  • Structure and evolutionary history of a large family of NLR proteins in the zebrafish.

    Howe K, Schiffer PH, Zielinski J, Wiehe T, Laird GK et al.

    Open biology 2016;6;4;160009

  • gEVAL - a web-based browser for evaluating genome assemblies.

    Chow W, Brugger K, Caccamo M, Sealy I, Torrance J and Howe K

    Bioinformatics (Oxford, England) 2016;32;16;2508-10

  • Using optical mapping data for the improvement of vertebrate genome assemblies.

    Howe K and Wood JM

    GigaScience 2015;4;10

  • The zebrafish reference genome sequence and its relationship to the human genome.

    Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C et al.

    Nature 2013;496;7446;498-503

  • Modernizing reference genome assemblies.

    Church DM, Schneider VA, Graves T, Auger K, Cunningham F et al.

    PLoS biology 2011;9;7;e1001091

  • Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly.

    Schneider VA, Graves-Lindsay T, Howe K, Bouk N, Chen HC et al.

    Genome research 2017;27;5;849-864

  • A New Chicken Genome Assembly Provides Insight into Avian Genome Structure.

    Warren WC, Hillier LW, Tomlinson C, Minx P, Kremitzki M et al.

    G3 (Bethesda, Md.) 2017;7;1;109-117

  • gEVAL - a web-based browser for evaluating genome assemblies.

    Chow W, Brugger K, Caccamo M, Sealy I, Torrance J and Howe K

    Bioinformatics (Oxford, England) 2016;32;16;2508-10

  • Structure and evolutionary history of a large family of NLR proteins in the zebrafish.

    Howe K, Schiffer PH, Zielinski J, Wiehe T, Laird GK et al.

    Open biology 2016;6;4;160009

  • The pig X and Y Chromosomes: structure, sequence, and evolution.

    Skinner BM, Sargent CA, Churcher C, Hunt T, Herrero J et al.

    Genome research 2016;26;1;130-9

  • Third Report on Chicken Genes and Chromosomes 2015.

    Schmid M, Smith J, Burt DW, Aken BL, Antin PB et al.

    Cytogenetic and genome research 2015;145;2;78-179

  • Using optical mapping data for the improvement of vertebrate genome assemblies.

    Howe K and Wood JM

    GigaScience 2015;4;10

  • The zebrafish reference genome sequence and its relationship to the human genome.

    Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C et al.

    Nature 2013;496;7446;498-503

  • Analyses of pig genomes provide insight into porcine demography and evolution.

    Groenen MA, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y et al.

    Nature 2012;491;7424;393-8

  • Comparison of the exomes of common carp (Cyprinus carpio) and zebrafish (Danio rerio).

    Henkel CV, Dirks RP, Jansen HJ, Forlenza M, Wiegertjes GF et al.

    Zebrafish 2012;9;2;59-67

  • Ensembl's 10th year.

    Flicek P, Aken BL, Ballester B, Beal K, Bragin E et al.

    Nucleic acids research 2010;38;Database issue;D557-62

  • The vertebrate genome annotation (Vega) database.

    Wilming LG, Gilbert JG, Howe K, Trevanion S, Hubbard T and Harrow JL

    Nucleic acids research 2008;36;Database issue;D753-60

  • Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V(L)-J(L)-C(L)) gene clusters.

    Zimmerman AM, Yeo G, Howe K, Maddox BJ and Steiner LA

    Developmental and comparative immunology 2008;32;4;421-34

  • Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates.

    Kikuta H, Laplante M, Navratilova P, Komisarczuk AZ, Engström PG et al.

    Genome research 2007;17;5;545-55

  • The genomic sequence and analysis of the swine major histocompatibility complex.

    Renard C, Hart E, Sehra H, Beasley H, Coggill P et al.

    Genomics 2006;88;1;96-110

  • The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z.

    Danilova N, Bussmann J, Jekosch K and Steiner LA

    Nature immunology 2005;6;3;295-302

  • The Vertebrate Genome Annotation (Vega) database.

    Ashurst JL, Chen CK, Gilbert JG, Jekosch K, Keenan S et al.

    Nucleic acids research 2005;33;Database issue;D459-65

  • Resolution of the novel immune-type receptor gene cluster in zebrafish.

    Yoder JA, Litman RT, Mueller MG, Desai S, Dobrinski KP et al.

    Proceedings of the National Academy of Sciences of the United States of America 2004;101;44;15706-11

  • Finishing the euchromatic sequence of the human genome.

    International Human Genome Sequencing Consortium

    Nature 2004;431;7011;931-45

  • An overview of Ensembl.

    Birney E, Andrews TD, Bevan P, Caccamo M, Chen Y et al.

    Genome research 2004;14;5;925-8

  • The zebrafish genome project: sequence analysis and annotation.

    Jekosch K

    Methods in cell biology 2004;77;225-39

  • The DNA sequence and comparative analysis of human chromosome 20.

    Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG et al.

    Nature 2001;414;6866;865-71

  • Loss of glucose repression in an Acremonium chrysogenum beta-lactam producer strain and its restoration by multiple copies of the cre1 gene.

    Jekosch K and Kück U

    Applied microbiology and biotechnology 2000;54;4;556-63

  • DNA sequence analysis of the complete mitochondrial genome of the green alga Scenedesmus obliquus: evidence for UAG being a leucine and UCA being a non-sense codon.

    Kück U, Jekosch K and Holzamer P

    Gene 2000;253;1;13-8

  • Glucose dependent transcriptional expression of the cre1 gene in Acremonium chrysogenum strains showing different levels of cephalosporin C production.

    Jekosch K and Kück U

    Current genetics 2000;37;6;388-95

Howe, Kerstin