Advanced Research Assistant in the Billker Group looking at the Molecular and Cellular Genetics of Plasmodium Bergehi.
My role is primarily involved in constructing and testing new molecular tools to allow us to further probe P.bergehi biology. Initially I built a range of tagging vectors to extend the range and utilise the modular nature of our targeting vector pipeline. Since then I have produced and adapted of a range of Overexpression, FACS sortable, and Conditional systems to utilise our recombineering approach. I am also involved in the multiplexed, high throughput, growth phenotyping screen of Knock out genes produced in our PlasmoGEM pipeline.
A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite.
Cell host & microbe 2015;17;3;404-13
PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.
Nucleic acids research 2015;43;Database issue;D1176-82
A systematic genome-wide analysis of zebrafish protein-coding gene function.
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
Andersen-Tawil syndrome: new potassium channel mutations and possible phenotypic variation.
Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia.
Brain : a journal of neurology 2004;127;Pt 12;2682-92
Functional characterization of compound heterozygosity for GlyRalpha1 mutations in the startle disease hyperekplexia.
The European journal of neuroscience 2002;16;2;186-96