Colin Herd | Advanced Research Assistant

This person is a member of Sanger Institute Alumni.

Herd, Colin

Advanced Research Assistant in the Billker Group looking at the Molecular and Cellular Genetics of Plasmodium Bergehi.

My role is primarily involved in constructing and testing new molecular tools to allow us to further probe P.bergehi biology. Initially I built a range of tagging vectors to extend the range and utilise the modular nature of our targeting vector pipeline. Since then I have produced and adapted of a range of Overexpression, FACS sortable, and Conditional systems to utilise our recombineering approach. I am also involved in the multiplexed, high throughput, growth phenotyping screen of Knock out genes produced in our PlasmoGEM pipeline.

Publications

  • A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite.

    Gomes AR, Bushell E, Schwach F, Girling G, Anar B et al.

    Cell host & microbe 2015;17;3;404-13

  • PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.

    Schwach F, Bushell E, Gomes AR, Anar B, Girling G et al.

    Nucleic acids research 2015;43;Database issue;D1176-82

  • A systematic genome-wide analysis of zebrafish protein-coding gene function.

    Kettleborough RN, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E et al.

    Nature 2013;496;7446;494-7

  • The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.

    Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A et al.

    Nature 2012;486;7402;266-70

  • Andersen-Tawil syndrome: new potassium channel mutations and possible phenotypic variation.

    Davies NP, Imbrici P, Fialho D, Herd C, Bilsland LG et al.

    Neurology 2005;65;7;1083-9

  • Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia.

    Imbrici P, Jaffe SL, Eunson LH, Davies NP, Herd C et al.

    Brain : a journal of neurology 2004;127;Pt 12;2682-92

  • Functional characterization of compound heterozygosity for GlyRalpha1 mutations in the startle disease hyperekplexia.

    Rea R, Tijssen MA, Herd C, Frants RR and Kullmann DM

    The European journal of neuroscience 2002;16;2;186-96

Herd, Colin