Eva Heinz | Senior Staff Scientist

Heinz, Eva

I am interested in the evolution of bacterial pathogens, using bioinformatics and large genomic datasets to understand why some lineages are highly successful, and how transmission efficiency, antimicrobial resistance, virulence mechanisms and other factors interplay.

My current work focuses on gram-negative bacterial (opportunistic) pathogens; to understand how antimicrobial resistance spreads via mobile elements as well as repeated independent acquisitions of intrinsic mechanisms through changes in the chromosome, and what impact the resistance mechanisms have on the bacterial cell beyond protection from antimicrobials. Part of my work also focuses on bacterial cell envelopes, where my interests are in improved vaccine design, as well as to study membrane proteins to understand how changes of proteins performing import/efflux can influence drug resistance.

Publications

  • Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan.

    Ejaz H, Wang N, Wilksch JJ, Page AJ, Cao H et al.

    Emerging infectious diseases 2017;23;11;1872-1875

  • The diversity of Klebsiella pneumoniae surface polysaccharides.

    Follador R, Heinz E, Wyres KL, Ellington MJ, Kowarik M et al.

    Microbial genomics 2016;2;8;e000073

  • Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.

    Heinz E, Stubenrauch CJ, Grinter R, Croft NP, Purcell AW et al.

    Genome biology and evolution 2016;8;6;1690-705

  • Evolution of the Translocation and Assembly Module (TAM).

    Heinz E, Selkrig J, Belousoff MJ and Lithgow T

    Genome biology and evolution 2015;7;6;1628-43

  • Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites.

    Heinz E, Hacker C, Dean P, Mifsud J, Goldberg AV et al.

    PLoS pathogens 2014;10;12;e1004547

  • The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.

    Heinz E, Williams TA, Nakjang S, Noël CJ, Swan DC et al.

    PLoS pathogens 2012;8;10;e1002979

  • Reshaping the tree of life.

    Heinz E and Domman D

    Nature reviews. Microbiology 2017;15;6;322

  • Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis.

    Freibert SA, Goldberg AV, Hacker C, Molik S, Dean P et al.

    Nature communications 2017;8;13932

  • The diversity of Klebsiella pneumoniae surface polysaccharides.

    Follador R, Heinz E, Wyres KL, Ellington MJ, Kowarik M et al.

    Microbial genomics 2016;2;8;e000073

  • Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.

    Heinz E, Stubenrauch CJ, Grinter R, Croft NP, Purcell AW et al.

    Genome biology and evolution 2016;8;6;1690-705

  • Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module.

    Selkrig J, Belousoff MJ, Headey SJ, Heinz E, Shiota T et al.

    Scientific reports 2015;5;12905

  • Evolution of the Translocation and Assembly Module (TAM).

    Heinz E, Selkrig J, Belousoff MJ and Lithgow T

    Genome biology and evolution 2015;7;6;1628-43

  • Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites.

    Heinz E, Hacker C, Dean P, Mifsud J, Goldberg AV et al.

    PLoS pathogens 2014;10;12;e1004547

  • Mitochondrial protein translocases for survival and wellbeing.

    Sokol AM, Sztolsztener ME, Wasilewski M, Heinz E and Chacinska A

    FEBS letters 2014;588;15;2484-95

  • A comprehensive analysis of the Omp85/TpsB protein superfamily structural diversity, taxonomic occurrence, and evolution.

    Heinz E and Lithgow T

    Frontiers in microbiology 2014;5;370

  • Back to basics: a revealing secondary reduction of the mitochondrial protein import pathway in diverse intracellular parasites.

    Heinz E and Lithgow T

    Biochimica et biophysica acta 2013;1833;2;295-303

  • The cellular roles of Ccr4-NOT in model and pathogenic fungi-implications for fungal virulence.

    Panepinto JC, Heinz E and Traven A

    Frontiers in genetics 2013;4;302

  • Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS.

    Dunstan RA, Heinz E, Wijeyewickrema LC, Pike RN, Purcell AW et al.

    PLoS pathogens 2013;9;1;e1003117

  • Identification and characterization of a novel porin family highlights a major difference in the outer membrane of chlamydial symbionts and pathogens.

    Aistleitner K, Heinz C, Hörmann A, Heinz E, Montanaro J et al.

    PloS one 2013;8;1;e55010

  • Reduction and expansion in microsporidian genome evolution: new insights from comparative genomics.

    Nakjang S, Williams TA, Heinz E, Watson AK, Foster PG et al.

    Genome biology and evolution 2013;5;12;2285-303

  • A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways.

    Hewitt VL, Heinz E, Shingu-Vazquez M, Qu Y, Jelicic B et al.

    Proceedings of the National Academy of Sciences of the United States of America 2012;109;49;E3358-66

  • Evolution of the β-barrel assembly machinery.

    Webb CT, Heinz E and Lithgow T

    Trends in microbiology 2012;20;12;612-20

  • A bioinformatic strategy for the detection, classification and analysis of bacterial autotransporters.

    Celik N, Webb CT, Leyton DL, Holt KE, Heinz E et al.

    PloS one 2012;7;8;e43245

  • The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.

    Heinz E, Williams TA, Nakjang S, Noël CJ, Swan DC et al.

    PLoS pathogens 2012;8;10;e1002979

  • Proteomic analysis reveals a virtually complete set of proteins for translation and energy generation in elementary bodies of the amoeba symbiont Protochlamydia amoebophila.

    Sixt BS, Heinz C, Pichler P, Heinz E, Montanaro J et al.

    Proteomics 2011;11;10;1868-92

  • Informational gene phylogenies do not support a fourth domain of life for nucleocytoplasmic large DNA viruses.

    Williams TA, Embley TM and Heinz E

    PloS one 2011;6;6;e21080

  • Proteomic analysis of the outer membrane of Protochlamydia amoebophila elementary bodies.

    Heinz E, Pichler P, Heinz C, Op den Camp HJ, Toenshoff ER et al.

    Proteomics 2010;10;24;4363-76

  • Comprehensive in silico prediction and analysis of chlamydial outer membrane proteins reflects evolution and life style of the Chlamydiae.

    Heinz E, Tischler P, Rattei T, Myers G, Wagner M and Horn M

    BMC genomics 2009;10;634

  • Diversity of bacterial endosymbionts of environmental acanthamoeba isolates.

    Schmitz-Esser S, Toenshoff ER, Haider S, Heinz E, Hoenninger VM et al.

    Applied and environmental microbiology 2008;74;18;5822-31

  • An Acanthamoeba sp. containing two phylogenetically different bacterial endosymbionts.

    Heinz E, Kolarov I, Kästner C, Toenshoff ER, Wagner M and Horn M

    Environmental microbiology 2007;9;6;1604-9

  • Recovery of an environmental Chlamydia strain from activated sludge by co-cultivation with Acanthamoeba sp.

    Collingro A, Poppert S, Heinz E, Schmitz-Esser S, Essig A et al.

    Microbiology (Reading, England) 2005;151;Pt 1;301-9

Heinz, Eva
Eva's Timeline
2016

Joined the Sanger Institute as Senior Staff Scientist in the Microbial Pathogenesis team

2012

Research Fellow/Fellow Laureate Post-Doctoral Research Associate; Monash University, Melbourne, Australia

2009

Marie-Curie Fellow at Newcastle University, Newcastle, UK

2008

PhD, University of Vienna, Austria

2004

Magistra, University of Vienna, Austria