Dr Vera Grinkevich

Former Postdoctoral Fellow at the Sanger Institute

Alumni

This person is a member of Sanger Institute Alumni.

Resistance to chemotherapeutic and targeted anticancer drugs is one of the major causes for the lethal cancer progression. Genetic alterations (point mutations, amplifications and deletions) in the genomic DNA are the major causes of the both intrinsic and acquired resistance. Genome-wide CRISPR screens allow us to create a population of cells with single deletions covering whole human genome. Using cancer cell lines of different origin and current cancer treatments we perform resistance and sensitivity screens. This lets us to uncover the pathways which lead to cancer drug resistance, cancer sensitivity and understand better biology of cancer cells.

TOOLS

GeneSpy – Simple and fast gene-protein visualisation, gRNA and template design.

https://github.com/kulesha/geneSpy

My timeline

• Joined WTSI Sanger Insititute as a PostDoc, Cancer Genome Project.

• Started EMBO PostDoc, Department of Molecular BIology, Siena University, Italy.

• Received PhD at Karolinska Institute, Department of Microbiology, Tumour and Cell biology, Sweden.

• Master's Degree in Genetics St.Petersburg State University, Russia. Thesis at Cytology Institute.

• Bachelor's degree in Biology, St.Petersburg State University, Russia Thesis at Cytology Institute.

• Finished school-colledge 130, Novosibirsk, Russia.