Dr Rebecca A Gladstone | Senior Bioinformatician
I am currently a bioinformatician for the Global pneumococcal sequencing project AKA GPS (tweets as @pneumowatch). GPS is sequencing the genomes of over 20,000 Streptococcus pneumoniae, collected from around the globe focusing on the developing world where the burden of disease is often highest. The collection covers both disease and carriage isolates from children and adults from before during and after post pneumococcal conjugate vaccine. GPS aims to assess vaccine impact on the bacterial population structure, resistance and capsular switching, and further describe gene content, recombination and phylogeography.
I also regularly get involved in a number of other collaborative pneumococcal projects that are sequenced at The Sanger Institute and have a general interest in infectious disease epidemiology. I have come from a microbiology background, acquiring bioinformatic skills during my PhD at the University of Southampton studying 500 pneumococcal genomes.
Tweets as @becctococcus
Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2016;22;1;60.e9-60.e29
Genetic stability of pneumococcal isolates during 35 days of human experimental carriage.
Current methods for capsular typing of Streptococcus pneumoniae.
Journal of microbiological methods 2015;113;41-9
Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction.
R-M systems go on the offensive.
Nature reviews. Microbiology 2015;13;3;131
Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine.
PloS one 2013;8;5;e64731
Sampling methods for the study of pneumococcal carriage: a systematic review.
Continued control of pneumococcal disease in the UK - the impact of vaccination.
Journal of medical microbiology 2011;60;Pt 1;1-8