Dr Rebecca A Gladstone | Senior Bioinformatician

Gladstone, Rebecca A

I am currently a bioinformatician for the Global pneumococcal sequencing project AKA GPS (tweets as @pneumowatch). GPS is sequencing the genomes of over 20,000 Streptococcus pneumoniae, collected from around the globe focusing on the developing world where the burden of disease is often highest. The collection covers both disease and carriage isolates from children and adults from before during and after post pneumococcal conjugate vaccine. GPS aims to assess vaccine impact on the bacterial population structure, resistance and capsular switching, and further describe gene content, recombination and phylogeography.

I also regularly get involved in a number of other collaborative pneumococcal projects that are sequenced at The Sanger Institute and have a general interest in infectious disease epidemiology. I have come from a microbiology background, acquiring bioinformatic skills during my PhD at the University of Southampton studying 500 pneumococcal genomes.

Tweets as @becctococcus

Publications

  • Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA.

    Metcalf BJ, Gertz RE, Gladstone RA, Walker H, Sherwood LK et al.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2016;22;1;60.e9-60.e29

  • Genetic stability of pneumococcal isolates during 35 days of human experimental carriage.

    Gladstone RA, Gritzfeld JF, Coupland P, Gordon SB and Bentley SD

    Vaccine 2015;33;29;3342-5

  • Current methods for capsular typing of Streptococcus pneumoniae.

    Jauneikaite E, Tocheva AS, Jefferies JM, Gladstone RA, Faust SN et al.

    Journal of microbiological methods 2015;113;41-9

  • Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction.

    Gladstone RA, Jefferies JM, Tocheva AS, Beard KR, Garley D et al.

    Vaccine 2015;33;17;2015-21

  • R-M systems go on the offensive.

    Lees J and Gladstone RA

    Nature reviews. Microbiology 2015;13;3;131

  • Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine.

    Loman NJ, Gladstone RA, Constantinidou C, Tocheva AS, Jefferies JM et al.

    PloS one 2013;8;5;e64731

  • Sampling methods for the study of pneumococcal carriage: a systematic review.

    Gladstone RA, Jefferies JM, Faust SN and Clarke SC

    Vaccine 2012;30;48;6738-44

  • Continued control of pneumococcal disease in the UK - the impact of vaccination.

    Gladstone RA, Jefferies JM, Faust SN and Clarke SC

    Journal of medical microbiology 2011;60;Pt 1;1-8