Dr Stephen Doyle | Postdoctoral Fellow

Doyle, Stephen

I joined the Parasite Genomics group in 2015 as a Postdoctoral Fellow to work on the population genomics of drug selection in two important veterinary parasites, Haemonchus contortus and Teladorsagia circumcincta. This work is part of a larger BBSRC-funded project to utilise genomic resources to develop novel interventions to control endemic gastrointestinal parasites of small ruminants.

Publications

  • Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

    Doyle SR, Bourguinat C, Nana-Djeunga HC, Kengne-Ouafo JA, Pion SDS et al.

    PLoS neglected tropical diseases 2017;11;7;e0005816

  • Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.

    Choi YJ, Bisset SA, Doyle SR, Hallsworth-Pepin K, Martin J et al.

    PLoS genetics 2017;13;6;e1006857

  • Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus.

    Armoo S, Doyle SR, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2017;10;1;188

  • The genome of Onchocerca volvulus, agent of river blindness.

    Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A et al.

    Nature microbiology 2016;2;16216

  • Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay.

    Doyle SR, Armoo S, Renz A, Taylor MJ, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2016;9;1;536

  • PLAG1 deficiency impairs spermatogenesis and sperm motility in mice.

    Juma AR, Grommen SVH, O'Bryan MK, O'Connor AE, Merriner DJ et al.

    Scientific reports 2017;7;1;5317

  • Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

    Doyle SR, Bourguinat C, Nana-Djeunga HC, Kengne-Ouafo JA, Pion SDS et al.

    PLoS neglected tropical diseases 2017;11;7;e0005816

  • Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.

    Choi YJ, Bisset SA, Doyle SR, Hallsworth-Pepin K, Martin J et al.

    PLoS genetics 2017;13;6;e1006857

  • Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus.

    Armoo S, Doyle SR, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2017;10;1;188

  • You Are What You Eat: A Genomic Analysis of the Gut Microbiome of Captive and Wild Octopus vulgaris Paralarvae and Their Zooplankton Prey.

    Roura Á, Doyle SR, Nande M and Strugnell JM

    Frontiers in physiology 2017;8;362

  • The genome of Onchocerca volvulus, agent of river blindness.

    Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A et al.

    Nature microbiology 2016;2;16216

  • Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay.

    Doyle SR, Armoo S, Renz A, Taylor MJ, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2016;9;1;536

  • Massively parallel sequencing of customised forensically informative SNP panels on the MiSeq.

    Mehta B, Daniel R, Phillips C, Doyle S, Elvidge G and McNevin D

    Electrophoresis 2016;37;21;2832-2840

  • MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing.

    Wong NC, Pope BJ, Candiloro IL, Korbie D, Trau M et al.

    BMC bioinformatics 2016;17;98

  • Locating and Activating Molecular 'Time Bombs': Induction of Mycolata Prophages.

    Dyson ZA, Brown TL, Farrar B, Doyle SR, Tucci J et al.

    PloS one 2016;11;8;e0159957

  • Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat.

    Wong NC, Pope BJ, Candiloro I, Korbie D, Trau M et al.

    GigaScience 2015;4;55

  • Low-coverage MiSeq next generation sequencing reveals the mitochondrial genome of the Eastern Rock Lobster, Sagmariasus verreauxi.

    Doyle SR, Griffith IS, Murphy NP and Strugnell JM

    Mitochondrial DNA 2015;26;6;844-5

  • Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signals.

    Doyle SR, Kasinadhuni NR, Chan CK and Grant WN

    PloS one 2013;8;6;e67938

  • Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism.

    Doyle SR, Chan CK and Grant WN

    BMC biotechnology 2011;11;83

  • Mitochondrial gene therapy: an evaluation of strategies for the treatment of mitochondrial DNA disorders.

    Doyle SR and Chan CK

    Human gene therapy 2008;19;12;1335-48

  • Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells.

    Doyle SR and Chan CK

    Genetic vaccines and therapy 2007;5;11

Doyle, Stephen
Stephen's Timeline
2015

Joined the Parasite Genomics group, Wellcome Trust Sanger Institute

2012

Early Career Development Fellow, La Trobe University

2011

PhD, La Trobe University