Professor Gordon Dougan | Senior Group Leader

Dougan, Gordon

Professor Gordon Dougan's research focuses on the genetic analysis of host/pathogen interactions during infection, particularly those involving enteric bacteria. He has worked extensively in both academia and industry, making important contributions in the field of vaccinology where he has worked to improve vaccine delivery to poorly resourced regions.

Gordon has extensive teaching experience at both the undergraduate and postgraduate level. He has served on several editorial boards and regularly reviews manuscripts for high-impact journals. He is a consultant for industry and has founded biotechnology companies, including the single-chain antibody company VHSquared.


Gordon is a Fellow of the Royal Society, the Biology Society, the Academy of Medical Sciences and is an EMBO (European Molecular Biology Organization) member. He established the Centre for Molecular Microbiology and Infection (including a raising funding for a building) at Imperial College London and was the Board of Management representative for Pathogen Research for ten years (2004-2014) at the Sanger Institute where he is currently a Senior Group Leader.


Current position
Gordon is currently a Senior Group Leader at the Sanger Institute. His research focuses on the use of genomics to study host/pathogen interactions during infection. The team consists of 10-15 individuals including core scientists (in vivo, FACS (Fluorescence-activated cell sorting) and microscopy), Postdoctoral Fellows and PhD students.


On joining the Sanger Institute in 2004, Gordon reshaped the science, building new facilities and recruiting new Faculty. He nurtured links with the internal Mouse and Human Genetics programmes and established a global network of collaborators built around open-access policies. Gordon's current Faculty research investigates host/pathogen interactions associated with enteric bacterial pathogens, principally S. enterica serovar Typhi. He also directs other projects investigating the genetics of host susceptibility to infection through mouse and zebrafish infection screens.


Teaching
Gordon has been a university lecturer both in the UK and abroad (The Republic of Ireland) and has run or participated in many teaching courses for undergraduates, MSc or PhD students (both lecture courses and practical). He has lectured to science, dental, medical and pharmacy students and coordinated courses and assessments for these groups. Gordon has supervised over 60 successful PhD students, many of whom are now independent scientific leaders or occupy important positions in industry or government organisations. These include more than ten full Professors in the UK and abroad. Gordon also regularly participates in or organises scientific courses targeting young scientists and clinicians.


Industry and International work
Gordon worked for more than ten years for the multi-national pharmaceutical company, The Wellcome Foundation, which is now part of GSK. During this period he became Head of Molecular Biology, managing teams working on vaccines, humanised antibodies and scale-up systems. He contributed to the discovery of pertactin as a key protective antigen for acellular whooping cough vaccines and is now an advisor for many companies, serving as an Scientific Advisory Board (SAB) or Board member. Gordon was Chair of the SAB for Novartis Vaccines & Diagnostics for more than ten years and helped found the Novartis Vaccine Global Health Institute (NVGH).
He is currently on the board of The Hilleman Laboratories, a joint enterprise between Merck and The Wellcome Trust and has founded spin-out companies and served as a Trustee at the International Vaccine Institute in Korea. Gordon is also currently an SAB member for ICDDR-B (International Centre for Diarrhoeal Disease Research, Bangladesh) and has served as a member of several WHO (World Health Organization) Committees.

Publications

  • Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa.

    Okoro CK, Kingsley RA, Connor TR, Harris SR, Parry CM et al.

    Nature genetics 2012;44;11;1215-21

  • IFITM3 restricts the morbidity and mortality associated with influenza.

    Everitt AR, Clare S, Pertel T, John SP, Wash RS et al.

    Nature 2012;484;7395;519-23

  • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.

    Lawley TD, Clare S, Walker AW, Stares MD, Connor TR et al.

    PLoS pathogens 2012;8;10;e1002995

  • Evidence for several waves of global transmission in the seventh cholera pandemic.

    Mutreja A, Kim DW, Thomson NR, Connor TR, Lee JH et al.

    Nature 2011;477;7365;462-5

  • The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children.

    MacLennan CA, Gondwe EN, Msefula CL, Kingsley RA, Thomson NR et al.

    The Journal of clinical investigation 2008;118;4;1553-62

  • A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi.

    Baker S, Holt K, Whitehead S, Goodhead I, Perkins T et al.

    Molecular microbiology 2007;66;5;1207-18

  • Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota.

    Stecher B, Robbiani R, Walker AW, Westendorf AM, Barthel M et al.

    PLoS biology 2007;5;10;2177-89

  • Requirement of bic/microRNA-155 for normal immune function.

    Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P et al.

    Science (New York, N.Y.) 2007;316;5824;608-11

  • DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.

    Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J et al.

    Gut 2017

  • Genomic history of the seventh pandemic of cholera in Africa.

    Weill FX, Domman D, Njamkepo E, Tarr C, Rauzier J et al.

    Science (New York, N.Y.) 2017;358;6364;785-789

  • Integrated view of Vibrio cholerae in the Americas.

    Domman D, Quilici ML, Dorman MJ, Njamkepo E, Mutreja A et al.

    Science (New York, N.Y.) 2017;358;6364;789-793

  • Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.

    Stubenrauch CJ, Dougan G, Lithgow T and Heinz E

    Open biology 2017;7;11

  • Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan.

    Ejaz H, Wang N, Wilksch JJ, Page AJ, Cao H et al.

    Emerging infectious diseases 2017;23;11;1872-1875

  • Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391.

    Sullivan MJ, Forde BM, Prince DW, Ipe DS, Ben Zakour NL et al.

    Genome announcements 2017;5;42

  • Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.

    Berger CN, Crepin VF, Roumeliotis TI, Wright JC, Carson D et al.

    Cell metabolism 2017

  • Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).

    Mentzer AV, Tobias J, Wiklund G, Nordqvist S, Aslett M et al.

    Scientific reports 2017;7;1;12514

  • Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights.

    Kiu R, Caim S, Alcon-Giner C, Belteki G, Clarke P et al.

    Genome biology and evolution 2017;9;10;2707-2714

  • NBEAL2 is required for neutrophil and NK cell function and pathogen defense.

    Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA et al.

    The Journal of clinical investigation 2017;127;9;3521-3526

  • The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26-27 October 2016, Oxford, UK.

    Meiring JE, Gibani M and TyVAC Consortium Meeting Group

    Vaccine 2017

  • The role of sapA and yfgA in susceptibility to antibody-mediated complement-dependent killing and virulence of Salmonella enterica Typhimurium.

    Ondari EM, Heath JN, Klemm EJ, Langridge G, Barquist L et al.

    Infection and immunity 2017

  • Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

    Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G et al.

    Nature genetics 2017

  • Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

    Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W et al.

    Nature communications 2017;8;15013

  • Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

    Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK et al.

    The Journal of experimental medicine 2017;214;4;1111-1128

  • Typhoid in Africa and vaccine deployment.

    Dougan G

    The Lancet. Global health 2017;5;3;e236-e237

  • Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.

    Blohmke CJ, Hill J, Darton TC, Carvalho-Burger M, Eustace A et al.

    Frontiers in immunology 2017;8;1276

  • Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency.

    Kuijpers TW, Tool AT, van der Bijl I, de Boer M, van Houdt M et al.

    The Journal of allergy and clinical immunology 2016

  • The type III secretion system effector SptP of Salmonella enterica serovar Typhi.

    Johnson R, Byrne A, Berger CN, Klemm E, Crepin VF et al.

    Journal of bacteriology 2016

  • Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

    Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT et al.

    Cell metabolism 2016;24;5;740-752

  • New Approaches for Needed Vaccines: Bacteria

    MacLennan,C.A., Mutreja,A. and Dougan,G.

    The Vaccine Book: Second Edition 2016;311-29

  • Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway.

    Yu Y, Tsang JC, Wang C, Clare S, Wang J et al.

    Nature 2016;539;7627;102-106

  • ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

    Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G and Lehner PJ

    Cell reports 2016;17;3;653-659

  • An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid.

    Wong VK, Baker S, Connor TR, Pickard D, Page AJ et al.

    Nature communications 2016;7;12827

  • Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

    Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J et al.

    Nature genetics 2016;48;10;1211-7

  • Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.

    Karlsson SL, Thomson N, Mutreja A, Connor T, Sur D et al.

    PLoS neglected tropical diseases 2016;10;10;e0005044

  • Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.

    International Typhoid Consortium, Wong VK, Holt KE, Okoro C, Baker S et al.

    PLoS neglected tropical diseases 2016;10;9;e0004781

  • Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.

    Forbester JL, Hannan N, Vallier L and Dougan G

    Methods in molecular biology (Clifton, N.J.) 2016

  • C13orf31 (FAMIN) is a central regulator of immunometabolic function.

    Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL et al.

    Nature immunology 2016

  • Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.

    Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L et al.

    PLoS neglected tropical diseases 2016;10;8;e0004926

  • Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants.

    Crosnier C, Iqbal Z, Knuepfer E, Maciuca S, Perrin AJ et al.

    The Journal of biological chemistry 2016;291;27;14285-99

  • Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences.

    Mottram L, Speak AO, Selek RM, Cambridge EL, McIntyre Z et al.

    mBio 2016;7;3

  • Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.

    Heinz E, Stubenrauch CJ, Grinter R, Croft NP, Purcell AW et al.

    Genome biology and evolution 2016;8;6;1690-705

  • Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

    Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC et al.

    Nature communications 2016;7;11786

  • The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia.

    Pham Thanh D, Thompson CN, Rabaa MA, Sona S, Sopheary S et al.

    PLoS neglected tropical diseases 2016;10;6;e0004785

  • Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.

    Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS et al.

    The Journal of experimental medicine 2016;213;6;1061-77

  • Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics.

    Klemm E and Dougan G

    Cell host & microbe 2016;19;5;599-610

  • Microevolution of Monophasic Salmonella Typhimurium during Epidemic, United Kingdom, 2005-2010.

    Petrovska L, Mather AE, AbuOun M, Branchu P, Harris SR et al.

    Emerging infectious diseases 2016;22;4;617-24

  • T cell fate and clonality inference from single-cell transcriptomes.

    Stubbington MJT, Lönnberg T, Proserpio V, Clare S, Speak AO et al.

    Nature methods 2016;13;4;329-332

  • Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain.

    Pérez-Vázquez M, Oteo J, García-Cobos S, Aracil B, Harris SR et al.

    The Journal of antimicrobial chemotherapy 2016;71;4;887-96

  • Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

    Klemm EJ, Gkrania-Klotsas E, Hadfield J, Forbester JL, Harris SR et al.

    Nature microbiology 2016;1;3

  • A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions.

    Makendi C, Page AJ, Wren BW, Le Thi Phuong T, Clare S et al.

    PLoS neglected tropical diseases 2016;10;2;e0004446

  • Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1.

    Holt K, Kenyon JJ, Hamidian M, Schultz MB, Pickard DJ et al.

    Microbial genomics 2016;2;2;e000052

  • Quantitative proteomic analysis of Shigella flexneri and Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) reveals highly pure preparations.

    Maggiore L, Yu L, Omasits U, Rossi O, Dougan G et al.

    International journal of medical microbiology : IJMM 2016;306;2;99-108

  • Invasive Group A Streptococcus Infection among Children, Rural Kenya.

    Seale AC, Davies MR, Anampiu K, Morpeth SC, Nyongesa S et al.

    Emerging infectious diseases 2016;22;2;224-32

  • Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.

    Ingle DJ, Tauschek M, Edwards DJ, Hocking DM, Pickard DJ et al.

    Nature microbiology 2016;1;15010

  • A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure.

    Pham Thanh D, Karkey A, Dongol S, Ho Thi N, Thompson CN et al.

    eLife 2016;5

  • Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae.

    Ipe DS, Ben Zakour NL, Sullivan MJ, Beatson SA, Ulett KB et al.

    Infection and immunity 2015;84;1;307-19

  • Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription.

    Alasoo K, Martinez FO, Hale C, Gordon S, Powrie F et al.

    Scientific reports 2015;5;12524

  • Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells.

    Forbester JL, Goulding D, Vallier L, Hannan N, Hale C et al.

    Infection and immunity 2015;83;7;2926-34

  • GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

    Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R et al.

    Science (New York, N.Y.) 2015;348;6242;1481-5

  • Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.

    Carter GP, Chakravorty A, Pham Nguyen TA, Mileto S, Schreiber F et al.

    mBio 2015;6;3;e00551

  • The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.

    Yu Y, Wang C, Clare S, Wang J, Lee SC et al.

    The Journal of experimental medicine 2015;212;6;865-74

  • Non-typhoidal Salmonella Typhimurium ST313 isolates that cause bacteremia in humans stimulate less inflammasome activation than ST19 isolates associated with gastroenteritis.

    Carden S, Okoro C, Dougan G and Monack D

    Pathogens and disease 2015;73;4

  • Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

    Toapanta FR, Bernal PJ, Fresnay S, Darton TC, Jones C et al.

    PLoS neglected tropical diseases 2015;9;6;e0003837

  • Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.

    Wong VK, Baker S, Pickard DJ, Parkhill J, Page AJ et al.

    Nature genetics 2015;47;6;632-9

  • Ceftriaxone-resistant Salmonella enterica serotype typhimurium sequence type 313 from Kenyan patients is associated with the blaCTX-M-15 gene on a novel IncHI2 plasmid.

    Kariuki S, Okoro C, Kiiru J, Njoroge S, Omuse G et al.

    Antimicrobial agents and chemotherapy 2015;59;6;3133-9

  • Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.

    McArthur MA, Fresnay S, Magder LS, Darton TC, Jones C et al.

    PLoS pathogens 2015;11;5;e1004914

  • Rapid emergence of multidrug resistant, H58-lineage Salmonella typhi in Blantyre, Malawi.

    Feasey NA, Gaskell K, Wong V, Msefula C, Selemani G et al.

    PLoS neglected tropical diseases 2015;9;4;e0003748

  • Multidrug-resistant Salmonella enterica serotype Typhi, Gulf of Guinea Region, Africa.

    Baltazar M, Ngandjio A, Holt KE, Lepillet E, Pardos de la Gandara M et al.

    Emerging infectious diseases 2015;21;4;655-9

  • Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.

    Yeung AT, Hale C, Xia J, Tate PH, Goulding D et al.

    Scientific reports 2015;5;8908

  • An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei.

    Caboni M, Pédron T, Rossi O, Goulding D, Pickard D et al.

    PLoS pathogens 2015;11;3;e1004749

  • Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa.

    Okoro CK, Barquist L, Connor TR, Harris SR, Clare S et al.

    PLoS neglected tropical diseases 2015;9;3;e0003611

  • The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions.

    Schreiber F, Kay S, Frankel G, Clare S, Goulding D et al.

    Scientific reports 2015;5;7947

  • Patterns of genome evolution that have accompanied host adaptation in Salmonella.

    Langridge GC, Fookes M, Connor TR, Feltwell T, Feasey N et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;3;863-8

  • Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance.

    Davies MR, Holden MT, Coupland P, Chen JH, Venturini C et al.

    Nature genetics 2015;47;1;84-7

  • Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

    Hale C, Yeung A, Goulding D, Pickard D, Alasoo K et al.

    PloS one 2015;10;5;e0124307

  • Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone.

    Ben Zakour NL, Davies MR, You Y, Chen JH, Forde BM et al.

    Scientific reports 2015;5;15877

  • Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution.

    von Mentzer A, Connor TR, Wieler LH, Semmler T, Iguchi A et al.

    Nature genetics 2014;46;12;1321-6

  • Drug resistance in Salmonella enterica ser. Typhimurium bloodstream infection, Malawi.

    Feasey NA, Cain AK, Msefula CL, Pickard D, Alaerts M et al.

    Emerging infectious diseases 2014;20;11;1957-9

  • CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

    Linterman MA, Denton AE, Divekar DP, Zvetkova I, Kane L et al.

    eLife 2014;3

  • Emergence of a new epidemic Neisseria meningitidis serogroup A Clone in the African meningitis belt: high-resolution picture of genomic changes that mediate immune evasion.

    Lamelas A, Harris SR, Röltgen K, Dangy JP, Hauser J et al.

    mBio 2014;5;5;e01974-14

  • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

    Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD et al.

    Cell host & microbe 2014;16;4;504-16

  • Typhoid fever in Fiji: a reversible plague?

    Thompson CN, Kama M, Acharya S, Bera U, Clemens J et al.

    Tropical medicine & international health : TM & IH 2014;19;10;1284-92

  • Antibacterial resistance in sub-Saharan Africa: an underestimated emergency.

    Kariuki S and Dougan G

    Annals of the New York Academy of Sciences 2014;1323;43-55

  • Transient Darwinian selection in Salmonella enterica serovar Paratyphi A during 450 years of global spread of enteric fever.

    Zhou Z, McCann A, Weill FX, Blin C, Nair S et al.

    Proceedings of the National Academy of Sciences of the United States of America 2014;111;33;12199-204

  • TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

    van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K et al.

    Proceedings of the National Academy of Sciences of the United States of America 2014;111;31;11425-30

  • Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.

    Da Cunha V, Davies MR, Douarre PE, Rosinski-Chupin I, Margarit I et al.

    Nature communications 2014;5;4544

  • The population structure of Vibrio cholerae from the Chandigarh Region of Northern India.

    Abd El Ghany M, Chander J, Mutreja A, Rashid M, Hill-Cawthorne GA et al.

    PLoS neglected tropical diseases 2014;8;7;e2981

  • Insertions in the OCL1 locus of Acinetobacter baumannii lead to shortened lipooligosaccharides.

    Kenyon JJ, Holt KE, Pickard D, Dougan G and Hall RM

    Research in microbiology 2014;165;6;472-5

  • Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.

    Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K et al.

    The Journal of clinical investigation 2014;124;7;2988-3002

  • The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.

    van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK et al.

    Cell host & microbe 2014;15;6;729-740

  • Complete Genome Sequences of Two Citrobacter rodentium Bacteriophages, CR8 and CR44b.

    Toribio AL, Pickard D, Cerdeño-Tárraga AM, Petty NK, Thomson N et al.

    Genome announcements 2014;2;3

  • An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.

    Waddington CS, Darton TC, Jones C, Haworth K, Peters A et al.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014;58;9;1230-40

  • Global dissemination of a multidrug resistant Escherichia coli clone.

    Petty NK, Ben Zakour NL, Stanton-Cook M, Skippington E, Totsika M et al.

    Proceedings of the National Academy of Sciences of the United States of America 2014;111;15;5694-9

  • Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

    Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G et al.

    Cell host & microbe 2014;15;4;471-83

  • Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure.

    De Chiara M, Hood D, Muzzi A, Pickard DJ, Perkins T et al.

    Proceedings of the National Academy of Sciences of the United States of America 2014;111;14;5439-44

  • A GC1 Acinetobacter baumannii isolate carrying AbaR3 and the aminoglycoside resistance transposon TnaphA6 in a conjugative plasmid.

    Hamidian M, Holt KE, Pickard D, Dougan G and Hall RM

    The Journal of antimicrobial chemotherapy 2014;69;4;955-8

  • Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.

    Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP et al.

    BMC genomics 2014;15;160

  • Identification of a marker for two lineages within the GC1 clone of Acinetobacter baumannii.

    Hamidian M, Wynn M, Holt KE, Pickard D, Dougan G and Hall RM

    The Journal of antimicrobial chemotherapy 2014;69;2;557-8

  • Genomic epidemiology of Vibrio cholerae O1 associated with floods, Pakistan, 2010.

    Shah MA, Mutreja A, Thomson N, Baker S, Parkhill J et al.

    Emerging infectious diseases 2014;20;1;13-20

  • Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever.

    Dougan G and Baker S

    Annual review of microbiology 2014;68;317-36

  • Tracking the establishment of local endemic populations of an emergent enteric pathogen.

    Holt KE, Thieu Nga TV, Thanh DP, Vinh H, Kim DW et al.

    Proceedings of the National Academy of Sciences of the United States of America 2013;110;43;17522-7

  • Identification of Salmonella enterica serovar Typhi genotypes by use of rapid multiplex ligation-dependent probe amplification.

    Pham Thanh D, Tran Vu Thieu N, Tran Thuy C, Lodén M, Tuin K et al.

    Journal of clinical microbiology 2013;51;9;2950-8

  • The agr locus regulates virulence and colonization genes in Clostridium difficile 027.

    Martin MJ, Clare S, Goulding D, Faulds-Pain A, Barquist L et al.

    Journal of bacteriology 2013;195;16;3672-81

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Characterization of the yehUT two-component regulatory system of Salmonella enterica Serovar Typhi and Typhimurium.

    Wong VK, Pickard DJ, Barquist L, Sivaraman K, Page AJ et al.

    PloS one 2013;8;12;e84567

  • Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.

    Everitt AR, Clare S, McDonald JU, Kane L, Harcourt K et al.

    PloS one 2013;8;11;e80723

  • Emergence and global spread of epidemic healthcare-associated Clostridium difficile.

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Dougan, Gordon