Sophia David is a PhD student in the Pathogen Genomics team and uses whole genome sequencing to improve our understanding of the diversity and evolution of the bacterium, Legionella pneumophila.
I am a third year PhD student at the Wellcome Trust Sanger Institute and Public Health England and am supervised by Prof. Julian Parkhill and Dr Tim Harrison. My PhD project is focused on developing our understanding of the bacterium, Legionella pneumophila, the causative agent of Legionnaires’ disease. We have used whole genome sequencing (WGS) of a large number of isolates from some of the major disease-causing strains of L. pneumophila to investigate their diversity, evolution and emergence as important human pathogens.
I am also interested in the development of a new molecular typing scheme using WGS data, which will be used by the international community for surveillance purposes and outbreak investigations. As part of my PhD project, I have been evaluating different methods for using WGS data in a typing scheme, and am now part of the European Study Group for Legionella Infections (ESGLI) working group that aims to formally validate and set up the scheme.