As an Associate Faculty member Danesh will be working with the Institute to further understand cardiometabolic traits through combining cardiovascular epidemiology with genomic research techniques. His research focus is on providing novel insights into the causes and predictors of coronary heart disease.
Danesh’s research has helped to pioneer the use, at scale, of integrative population approaches to provide novel insights into the causes and predictors of coronary heart disease (CHD), demonstrating causal roles for interleukin-6 signalling, IL-1 signalling, and triglyceride-mediated pathways. His work on risk prediction has significantly influenced risk management, and has been cited in no less than 10 major guidelines since 2009. More recently, he has led major initiatives to improve the safety and efficiency of blood donation through strategic collaborations with NHS Blood and Transplant.
Danesh has been a leader and advocate of “team science” in international health research. For example, he created and direct the 2.5 million-participant Emerging Risk Factors Collaboration which elucidates the relevance of cardiovascular risk factors (>100 scientists from >25 countries) and the 520,000-participant pan-European EPIC-CVD consortium which studies the interplay of genetic and lifestyle factors (>60 scientists from 12 countries). He has led the creation of major bioresources that benefit the UK research community (eg, the 50,000-participant INTERVAL study) and the international research community (eg, as co-PI of studies in Bangladesh and Pakistan that have recruited >50,000 participants).
Danesh has helped shape national research strategy through external advisory roles (eg, MRC PSM Board, MRC Global Health Group, Wellcome Trust Genetics Panel, UK Biobank Steering Committee).
Since 2001, Danesh has led the Department of Public Health and Primary Care (University of Cambridge), one of Europe's leading academic population health departments, which has expanded >4-fold during his tenure (currently >400 members). He has helped to create joint appointments and innovative collaborations with strategic partners, including the NHS (eg, NHSBT), industry (eg, Pfizer-Cambridge Cardiovascular Genomics Centre), the not-for-profit sector (eg, RAND-Europe) and the Wellcome Trust Genome Campus.
Association of Cardiometabolic Multimorbidity With Mortality.
Glycated hemoglobin measurement and prediction of cardiovascular disease.
C-reactive protein, fibrinogen, and cardiovascular disease prediction.
The New England journal of medicine 2012;367;14;1310-20
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
Lancet (London, England) 2012;379;9822;1205-13
Lipid-related markers and cardiovascular disease prediction.
Diabetes mellitus, fasting glucose, and risk of cause-specific death.
The New England journal of medicine 2011;364;9;829-41
Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies.
Lancet (London, England) 2011;377;9771;1085-95
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
Lancet (London, England) 2010;375;9726;1634-9
Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies.
Lancet (London, England) 2010;375;9725;1536-44
C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.
The New England journal of medicine 2004;350;14;1387-97