Dr Ellen Bushell | Senior Staff Scientist

Bushell, Ellen

Working with Oliver Billker and Julian Rayner, I am the project manager for PlasmoGEM (http://plasmogem.sanger.ac.uk/), a Wellcome Trust Sanger Institute based project that generates and freely distributes tools for the genetic manipulation of the Plasmodium malaria parasites.

My primary research interest is the development of scable experimental genetic tools for the manipulation of the rodent malaria parasite Plasmodium berghei. My focus is on tools that allow for high-throughput screening of multiple genes in parallel, in loss-of-function as well as gain-of-function in vivo assays. I am particularly interested in using data from such assays to gain novel insight into mechanisms underpinning parasite pathogensis, metabolism and drug resistance.

Publications

  • A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite.

    Gomes AR, Bushell E, Schwach F, Girling G, Anar B et al.

    Cell host & microbe 2015;17;3;404-13

  • PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.

    Schwach F, Bushell E, Gomes AR, Anar B, Girling G et al.

    Nucleic acids research 2015;43;Database issue;D1176-82

  • A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.

    Sinha A, Hughes KR, Modrzynska KK, Otto TD, Pfander C et al.

    Nature 2014;507;7491;253-257

  • Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates.

    Ning J, Otto TD, Pfander C, Schwach F, Brochet M et al.

    Genes & development 2013;27;10;1198-215

  • Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion.

    Frénal K, Tay CL, Mueller C, Bushell ES, Jia Y et al.

    Traffic (Copenhagen, Denmark) 2013;14;8;895-911

  • Characterization of Plasmodium developmental transcriptomes in Anopheles gambiae midgut reveals novel regulators of malaria transmission.

    Akinosoglou KA, Bushell ES, Ukegbu CV, Schlegelmilch T, Cho JS et al.

    Cellular microbiology 2015;17;2;254-68

  • Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector.

    Bushell ES, Ecker A, Schlegelmilch T, Goulding D, Dougan G et al.

    PLoS pathogens 2009;5;8;e1000539

Bushell, Ellen
Ellen's Timeline
2011

Joined Wellcome Trust Sanger Institute Malaria Program as Staff Scientist

2009

Postdoctoral Fellowship FP7 EU Grant "Monitoring of transcriptional responses of Anopheles gambiae sympatric infections with Plasmodium falciparum", Imperial College London and Institut de Recherche pour le Développement (IRD), Bobo Dioulasso

2005

PhD Wellcome Trust 4-year PhD program, thesis title "Plasmodium genes responsible for oocyst development and interaction with its Anopheline vector", Imperial College London

2004

MRes Wellcome Trust 4-year PhD program, Molecular and Cellular Basis of Infection, Imperial College London

2000

BSc Hons Applied Biology, Cardiff University