Working with Oliver Billker and Julian Rayner, I am the project manager for PlasmoGEM (http://plasmogem.sanger.ac.uk/), a Wellcome Trust Sanger Institute based project that generates and freely distributes tools for the genetic manipulation of the Plasmodium malaria parasites.
My primary research interest is the development of scable experimental genetic tools for the manipulation of the rodent malaria parasite Plasmodium berghei. My focus is on tools that allow for high-throughput screening of multiple genes in parallel, in loss-of-function as well as gain-of-function in vivo assays. I am particularly interested in using data from such assays to gain novel insight into mechanisms underpinning parasite pathogensis, metabolism and drug resistance.
A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite.
Cell host & microbe 2015;17;3;404-13
PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.
Nucleic acids research 2015;43;Database issue;D1176-82
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.
Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates.
Genes & development 2013;27;10;1198-215
Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion.
Traffic (Copenhagen, Denmark) 2013;14;8;895-911
Characterization of Plasmodium developmental transcriptomes in Anopheles gambiae midgut reveals novel regulators of malaria transmission.
Cellular microbiology 2015;17;2;254-68
Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector.
PLoS pathogens 2009;5;8;e1000539