Allan Bradley | Senior Group Leader & Director Emeritus

Allan served as the Institute’s Director from 2000 to 2010.  During his ten-year tenure he shifted the Institute’s scientific programmes from a sequence production and informatics to a more genetically and biologically focused academic genome centre.  He emphasised investment in young scientists, recruiting a cadre of young PIs, established international PhD programs for both basic and clinically trained candidates.    

Professor Bradley led a research group through his tenure as Institute Director and continues to do so as a Senior Group Leader.  Allan’s laboratory environment emphasises intellectual rigour but with a flair for innovation and creativity.  His laboratory’s research is strongly focused on using genetics to discover genes involved in various biological systems, using somatic mutagenesis in mice to discover cancer genes and genetic screens in  ES cells in culture.  He is considers himself to be an “educator”, inspiring and mentoring graduate students and fellows.  His laboratory is an active and successful training environment for postdoctoral and clinical fellows.  Professor Bradley places special emphasis in mentoring and preparing young scientists for independent academic positions both in the UK and globally.  Laboratory alumni include 22 independent PIs in 6 countries of whom 10 are full professors, or equivalent.

Allan is also a serial entrepreneur, establishing  several biotechnology companies.  While in the USA he founded two companies; Lexicon Pharmaceuticals Inc. is publicly traded while Spectral Genomics Inc. was acquired.  In 2010 he founded Kymab Ltd., which now employs more than 80 scientists.  Many of Prof. Bradley’s trainees have joined these spin-outs.

 

Publications

  • Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines.

    Bradley A, Evans M, Kaufman MH and Robertson E

    Nature 1984;309;5965;255-6

  • A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice.

    Kuehn MR, Bradley A, Robertson EJ and Evans MJ

    Nature 1987;326;6110;295-8

  • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.

    Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA et al.

    Nature 1992;356;6366;215-21

  • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.

    Lee EY, Chang CY, Hu N, Wang YC, Lai CC et al.

    Nature 1992;359;6393;288-94

  • Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.

    Matzuk MM, Finegold MJ, Su JG, Hsueh AJ and Bradley A

    Nature 1992;360;6402;313-9

  • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.

    Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E et al.

    Nature 1997;386;6627;804-10

  • p63 is a p53 homologue required for limb and epidermal morphogenesis.

    Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR and Bradley A

    Nature 1999;398;6729;708-13

  • Engineering a mouse balancer chromosome.

    Zheng B, Sage M, Cai WW, Thompson DM, Tavsanli BC et al.

    Nature genetics 1999;22;4;375-8

  • Cancer predisposition caused by elevated mitotic recombination in Bloom mice.

    Luo G, Santoro IM, McDaniel LD, Nishijima I, Mills M et al.

    Nature genetics 2000;26;4;424-9

  • Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.

    Guo G, Wang W and Bradley A

    Nature 2004;429;6994;891-5

  • Requirement of bic/microRNA-155 for normal immune function.

    Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P et al.

    Science (New York, N.Y.) 2007;316;5824;608-11

  • Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.

    Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H et al.

    Cell 2009;137;7;1235-46

  • A conditional knockout resource for the genome-wide study of mouse gene function.

    Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W et al.

    Nature 2011;474;7351;337-42

  • A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

    Prosser HM, Koike-Yusa H, Cooper JD, Law FC and Bradley A

    Nature biotechnology 2011;29;9;840-5

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.

    Lee EC, Liang Q, Ali H, Bayliss L, Beasley A et al.

    Nature biotechnology 2014;32;4;356-63

  • High-throughput discovery of novel developmental phenotypes.

    Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD et al.

    Nature 2016;537;7621;508-514

  • Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice.

    Sok D, Briney B, Jardine JG, Kulp DW, Menis S et al.

    Science (New York, N.Y.) 2016

  • Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.

    Zhang M, Cheng L, Jia Y, Liu G, Li C et al.

    The EMBO journal 2016

  • C13orf31 (FAMIN) is a central regulator of immunometabolic function.

    Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL et al.

    Nature immunology 2016

  • Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

    Rouhani FJ, Nik-Zainal S, Wuster A, Li Y, Conte N et al.

    PLoS genetics 2016;12;4;e1005932

  • Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.

    Maresch R, Mueller S, Veltkamp C, Öllinger R, Friedrich M et al.

    Nature communications 2016;7;10770

  • Chromosome engineering in zygotes with CRISPR/Cas9.

    Boroviak K, Doe B, Banerjee R, Yang F and Bradley A

    Genesis (New York, N.Y. : 2000) 2016;54;2;78-85

  • CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

    Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;45;13982-7

  • A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

    Dietlein F, Kalb B, Jokic M, Noll EM, Strong A et al.

    Cell 2015;162;1;146-59

  • Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.

    Tan EP, Li Y, Velasco-Herrera Mdel C, Yusa K and Bradley A

    Genesis (New York, N.Y. : 2000) 2015;53;2;225-36

  • A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

    Rad R, Rad L, Wang W, Strong A, Ponstingl H et al.

    Nature genetics 2015;47;1;47-56

  • High-density P300 enhancers control cell state transitions.

    Witte S, Bradley A, Enright AJ and Muljo SA

    BMC genomics 2015;16;903

  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

    Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C et al.

    Nature medicine 2014;20;11;1340-7

  • Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

    DiTommaso T, Jones LK, Cottle DL, WTSI Mouse Genetics Program, Gerdin AK et al.

    PLoS genetics 2014;10;10;e1004705

  • Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

    Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N et al.

    Proceedings of the National Academy of Sciences of the United States of America 2014;111;37;13427-32

  • Genetic background drives transcriptional variation in human induced pluripotent stem cells.

    Rouhani F, Kumasaka N, de Brito MC, Bradley A, Vallier L and Gaffney D

    PLoS genetics 2014;10;6;e1004432

  • Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.

    Lee EC, Liang Q, Ali H, Bayliss L, Beasley A et al.

    Nature biotechnology 2014;32;4;356-63

  • MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.

    Mok Y, Schwierzeck V, Thomas DC, Vigorito E, Rayner TF et al.

    Journal of immunology (Baltimore, Md. : 1950) 2013;191;6;3037-48

  • A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.

    Mupo A, Celani L, Dovey O, Cooper JL, Grove C et al.

    Leukemia 2013;27;9;1917-20

  • Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture.

    Conte N, Varela I, Grove C, Manes N, Yusa K et al.

    Leukemia 2013;27;9;1820-5

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

    Rad R, Cadiñanos J, Rad L, Varela I, Strong A et al.

    Cancer cell 2013;24;1;15-29

  • Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.

    Dovey OM, Foster CT, Conte N, Edwards SA, Edwards JM et al.

    Blood 2013;121;8;1335-44

  • Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

    de la Rosa J, Freije JM, Cabanillas R, Osorio FG, Fraga MF et al.

    Nature communications 2013;4;2268

  • Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

    Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;600-10

  • Genetic screens using the piggyBac transposon.

    Chew SK, Rad R, Futreal PA, Bradley A and Liu P

    Methods (San Diego, Calif.) 2011;53;4;366-71

  • A hyperactive piggyBac transposase for mammalian applications.

    Yusa K, Zhou L, Li MA, Bradley A and Craig NL

    Proceedings of the National Academy of Sciences of the United States of America 2011;108;4;1531-6

  • PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.

    Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G et al.

    Science (New York, N.Y.) 2010;330;6007;1104-7

  • An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

    Pardo M, Lang B, Yu L, Prosser H, Bradley A et al.

    Cell stem cell 2010;6;4;382-95

  • Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

    Dietrich MF, van der Weyden L, Prosser HM, Bradley A, Herz J and Adams DJ

    PloS one 2010;5;4;e9960

  • Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.

    Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ et al.

    PLoS genetics 2009;5;12;e1000759

  • Agouti C57BL/6N embryonic stem cells for mouse genetic resources.

    Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM et al.

    Nature methods 2009;6;7;493-5

  • Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.

    Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H et al.

    Cell 2009;137;7;1235-46

  • Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons.

    Liang Q, Kong J, Stalker J and Bradley A

    Genesis (New York, N.Y. : 2000) 2009;47;6;404-8

  • Transposon-mediated genome manipulation in vertebrates.

    Ivics Z, Li MA, Mátés L, Boeke JD, Nagy A et al.

    Nature methods 2009;6;6;415-22

  • Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.

    Yusa K, Rad R, Takeda J and Bradley A

    Nature methods 2009;6;5;363-9

  • A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells.

    Wang W, Bradley A and Huang Y

    Genome research 2009;19;4;667-73

  • A DNA transposon-based approach to validate oncogenic mutations in the mouse.

    Su Q, Prosser HM, Campos LS, Ortiz M, Nakamura T et al.

    Proceedings of the National Academy of Sciences of the United States of America 2008;105;50;19904-9

  • Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.

    Lange UC, Adams DJ, Lee C, Barton S, Schneider R et al.

    Molecular and cellular biology 2008;28;15;4688-96

  • Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.

    van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G et al.

    Oncogene 2008;27;32;4503-8

  • Chromosomal transposition of PiggyBac in mouse embryonic stem cells.

    Wang W, Lin C, Lu D, Ning Z, Cox T et al.

    Proceedings of the National Academy of Sciences of the United States of America 2008;105;27;9290-5

  • Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.

    Prosser HM, Rzadzinska AK, Steel KP and Bradley A

    Molecular and cellular biology 2008;28;5;1702-12

  • microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

    Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z et al.

    Immunity 2007;27;6;847-59

  • Requirement of bic/microRNA-155 for normal immune function.

    Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P et al.

    Science (New York, N.Y.) 2007;316;5824;608-11

  • Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.

    van der Weyden L, Wei L, Luo J, Yang X, Birk DE et al.

    The American journal of pathology 2006;169;2;515-27

  • TranscriptSNPView: a genome-wide catalog of mouse coding variation.

    Cunningham F, Rios D, Griffiths M, Smith J, Ning Z et al.

    Nature genetics 2006;38;8;853

  • Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.

    Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M et al.

    Genes & development 2006;20;14;1880-4

  • Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.

    van der Weyden L, Arends MJ, Chausiaux OE, Ellis PJ, Lange UC et al.

    Molecular and cellular biology 2006;26;9;3595-609

  • A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice.

    Yu YE, Morishima M, Pao A, Wang DY, Wen XY et al.

    Genetics 2006;173;1;297-307

  • DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

    Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J et al.

    Nature 2006;440;7087;1045-9

  • A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction.

    Adams DJ, Quail MA, Cox T, van der Weyden L, Gorick BD et al.

    Genomics 2005;86;6;753-8

  • The molecular clock mediates leptin-regulated bone formation.

    Fu L, Patel MS, Bradley A, Wagner EF and Karsenty G

    Cell 2005;122;5;803-15

  • The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis.

    van der Weyden L, Tachibana KK, Gonzalez MA, Adams DJ, Ng BL et al.

    Molecular and cellular biology 2005;25;18;8356-67

  • Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector.

    van der Weyden L, Adams DJ, Harris LW, Tannahill D, Arends MJ and Bradley A

    Genesis (New York, N.Y. : 2000) 2005;41;4;171-8

  • BRCTx is a novel, highly conserved RAD18-interacting protein.

    Adams DJ, van der Weyden L, Gergely FV, Arends MJ, Ng BL et al.

    Molecular and cellular biology 2005;25;2;779-88

  • Identification of mammalian microRNA host genes and transcription units.

    Rodriguez A, Griffiths-Jones S, Ashurst JL and Bradley A

    Genome research 2004;14;10A;1902-10

  • The European dimension for the mouse genome mutagenesis program.

    Auwerx J, Avner P, Baldock R, Ballabio A, Balling R et al.

    Nature genetics 2004;36;9;925-7

  • The knockout mouse project.

    Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M et al.

    Nature genetics 2004;36;9;921-4

  • Mutagenic insertion and chromosome engineering resource (MICER).

    Adams DJ, Biggs PJ, Cox T, Davies R, van der Weyden L et al.

    Nature genetics 2004;36;8;867-71

  • Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.

    Guo G, Wang W and Bradley A

    Nature 2004;429;6994;891-5

  • Functional genetic analysis of mouse chromosome 11.

    Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP et al.

    Nature 2003;425;6953;81-6

  • Mining the mouse genome.

    Bradley A

    Nature 2002;420;6915;512-4

  • Tools for targeted manipulation of the mouse genome.

    van der Weyden L, Adams DJ and Bradley A

    Physiological genomics 2002;11;3;133-64

  • Cancer: stuck at first base.

    van der Weyden L, Jonkers J and Bradley A

    Nature 2002;419;6903;127-8

  • p53 mutant mice that display early ageing-associated phenotypes.

    Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N et al.

    Nature 2002;415;6867;45-53

  • Induced mitotic recombination: a switch in time.

    Adams DJ and Bradley A

    Nature genetics 2002;30;1;6-7

  • An SSLP marker-anchored BAC framework map of the mouse genome.

    Cai WW, Chow CW, Damani S, Gregory SG, Marra M and Bradley A

    Nature genetics 2001;29;2;133-4

  • Engineering chromosomal rearrangements in mice.

    Yu Y and Bradley A

    Nature reviews. Genetics 2001;2;10;780-90

  • Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice.

    Cleary MA, van Raamsdonk CD, Levorse J, Zheng B, Bradley A and Tilghman SM

    Nature genetics 2001;29;1;78-82

  • Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.

    Lindsay EA, Vitelli F, Su H, Morishima M, Huynh T et al.

    Nature 2001;410;6824;97-101

  • Cancer predisposition caused by elevated mitotic recombination in Bloom mice.

    Luo G, Santoro IM, McDaniel LD, Nishijima I, Mills M et al.

    Nature genetics 2000;26;4;424-9

  • Requirement for Wnt3 in vertebrate axis formation.

    Liu P, Wakamiya M, Shea MJ, Albrecht U, Behringer RR and Bradley A

    Nature genetics 1999;22;4;361-5

  • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.

    Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E et al.

    Nature 1997;386;6627;804-10

Bradley, Allan
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Allan's Timeline
2014

Publication of Complete humanization of immunoglobulin loci in mice

Chief Technical Officer Kymab Limited (part time)

2012

Chief Scientific Officer Kymab Limited (part time

ISTT Prize

2010

Founded Kymab Limited

Stepped down as Director of the Sanger Institute

2006

Elected EMBO Member

2004

Peter Debye Prize

2002

Elected Fellow of The Royal Society

Elected Fellow of Academy of Medical Sciences

2000

Founded Spectral Genomics Inc

Appointed Director of the Sanger Centre

1997

Appointed Howard Hughes Medical Institute Investigator

1995

Appointed Full Professor, Baylor College of Medicine

Publication of Chromosome Engineering

Founded Lexicon Genetics

1992

Publication of p53 and Rb knockouts

Appointed Assistant Investigator, Howard Hughes Medical Institute

Appointed Associate Professor, Baylor College of Medicine

1987

Appointed Assistant Professor, Baylor College of Medicine

Publication of first knockout generated via ES cells

1984

PhD Genetics, Cambridge UK

Beit Memorial Fellow

Publication of germ line transmission of ES cells

1981

BA Genetics, Cambridge UK