Dr Lara Bossini-Castillo | Postdoctoral Fellow

Bossini-Castillo, Lara

Lara is a Postdoctoral Fellow in the Trynka Lab. Lara’s research is focused in how human genetic variability shapes the control of the immune system and contributes to the onset of complex immune-related diseases. She is particularly interested in deciphering the functional meaning of the genetic polymorphisms that have been associated with autoimmune diseases in genome-wide association studies (GWAS).

I shifted towards immunogenomics after joining Prof. Javier Martín’s group (Granada, Spain) for PhD training in medical-population genetics with focus on complex immune traits. During my PhD, I studied the genetic basis of autoimmune diseases, with a particular emphasis on systemic sclerosis. In this period, I combined my background as a biologist and my training in immunology with my interests in informatics and addressed computationally driven research problems. I was a co-lead analyst in an Immunochip-based study in systemic sclerosis and several GWAS and GWAS follow-up studies in different diseases. These studies contributed to the identification of a number of genetic regions associated with autoimmune diseases.

As a Postdoctoral Fellow my main aim is to evolve from locus discovery towards identification of causal variants by using computational and functional genomics.

Publications

  • Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

    López-Isac E, Campillo-Davo D, Bossini-Castillo L, Guerra SG, Assassi S et al.

    Annals of the rheumatic diseases 2016;75;8;1521-6

  • Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways.

    Bossini-Castillo L, López-Isac E and Martín J

    Journal of autoimmunity 2015;64;53-65

  • Genetics of systemic sclerosis.

    Bossini-Castillo L, López-Isac E, Mayes MD and Martín J

    Seminars in immunopathology 2015;37;5;443-51

  • A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.

    Carmona FD, Mackie SL, Martín JE, Taylor JC, Vaglio A et al.

    American journal of human genetics 2015;96;4;565-80

  • HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.

    Guéant JL, Romano A, Cornejo-Garcia JA, Oussalah A, Chery C et al.

    The Journal of allergy and clinical immunology 2015;135;1;253-9

  • A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.

    Bossini-Castillo L, de Kovel C, Kallberg H, van 't Slot R, Italiaander A et al.

    Annals of the rheumatic diseases 2015;74;3;e15

  • Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

    Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X et al.

    American journal of human genetics 2014;94;1;47-61

  • Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study.

    Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L et al.

    Annals of the rheumatic diseases 2013;72;4;602-7

  • A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.

    Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeón CP et al.

    Human molecular genetics 2012;21;4;926-33

  • A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.

    Bossini-Castillo L, Broen JC, Simeon CP, Beretta L, Vonk MC et al.

    Annals of the rheumatic diseases 2011;70;4;638-41

  • Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

    López-Isac E, Campillo-Davo D, Bossini-Castillo L, Guerra SG, Assassi S et al.

    Annals of the rheumatic diseases 2016;75;8;1521-6

  • Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways.

    Bossini-Castillo L, López-Isac E and Martín J

    Journal of autoimmunity 2015;64;53-65

  • Genetics of systemic sclerosis.

    Bossini-Castillo L, López-Isac E, Mayes MD and Martín J

    Seminars in immunopathology 2015;37;5;443-51

  • A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.

    Carmona FD, Mackie SL, Martín JE, Taylor JC, Vaglio A et al.

    American journal of human genetics 2015;96;4;565-80

  • A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.

    Bossini-Castillo L, de Kovel C, Kallberg H, van 't Slot R, Italiaander A et al.

    Annals of the rheumatic diseases 2015;74;3;e15

  • HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.

    Guéant JL, Romano A, Cornejo-Garcia JA, Oussalah A, Chery C et al.

    The Journal of allergy and clinical immunology 2015;135;1;253-9

  • Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus.

    López-Isac E, Bossini-Castillo L, Guerra SG, Denton C, Fonseca C et al.

    Arthritis & rheumatology (Hoboken, N.J.) 2014;66;12;3521-3

  • Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

    Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X et al.

    American journal of human genetics 2014;94;1;47-61

  • Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study.

    Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L et al.

    Annals of the rheumatic diseases 2013;72;4;602-7

  • IRF5 polymorphism predicts prognosis in patients with systemic sclerosis.

    Sharif R, Mayes MD, Tan FK, Gorlova OY, Hummers LK et al.

    Annals of the rheumatic diseases 2012;71;7;1197-202

  • Unraveling the genetic component of systemic sclerosis.

    Martín JE, Bossini-Castillo L and Martín J

    Human genetics 2012;131;7;1023-37

  • Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis.

    Coustet B, Bouaziz M, Dieudé P, Guedj M, Bossini-Castillo L et al.

    The Journal of rheumatology 2012;39;5;997-1003

  • A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.

    Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeón CP et al.

    Human molecular genetics 2012;21;4;926-33

  • Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.

    Bossini-Castillo L, Simeon CP, Beretta L, Vonk MC, Callejas-Rubio JL et al.

    Rheumatology (Oxford, England) 2011;50;11;1976-81

  • A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.

    Bossini-Castillo L, Broen JC, Simeon CP, Beretta L, Vonk MC et al.

    Annals of the rheumatic diseases 2011;70;4;638-41

  • [Genetics in scleroderma].

    Bossini-Castillo L, Martín JE, Díaz-Gallo LM, Rueda B and Martín J

    Reumatología clinica 2010;6 Suppl 2;12-5

Bossini-Castillo, Lara
Lara's Timeline
2015

PostDoc in Computational Genomics, Wellcome Trust Sanger Institute

2014

PhD in Medical Genetics, University of Granada

2011

MSc in Research and Advances in Molecular and Cellular Immunology, University of Granada

2009

BS in Biology, University of Granada (Spain)