Helen Beasley | Computer Biologist - Senior Genome Analyst

This person is a member of Sanger Institute Alumni.

Beasley, Helen

I manually improve the genome sequence of helminths as part of the Parasite Genomics Group - improving assemblies at the sequence level using software tools to close gaps and resolve mis-assemblies, and through the structural and functional curation of predicted genes models.

I joined the Sanger Institute as a finisher working on the Human Genome Project then other large genomes including zebrafish, mouse, pig, and tomato. In later years, I worked on finishing more problematic regions, alongside the coordination of projects from a broad range of sequencing collaborations.


  • The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode.

    Cotton JA, Lilley CJ, Jones LM, Kikuchi T, Reid AJ et al.

    Genome biology 2014;15;3;R43

  • The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery.

    Laing R, Kikuchi T, Martinelli A, Tsai IJ, Beech RN et al.

    Genome biology 2013;14;8;R88

  • The genomes of four tapeworm species reveal adaptations to parasitism.

    Tsai IJ, Zarowiecki M, Holroyd N, Garciarrubio A, Sánchez-Flores A et al.

    Nature 2013;496;7443;57-63

  • The zebrafish reference genome sequence and its relationship to the human genome.

    Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C et al.

    Nature 2013;496;7446;498-503

  • The tomato genome sequence provides insights into fleshy fruit evolution.

    Tomato Genome Consortium

    Nature 2012;485;7400;635-41

  • Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry.

    Joron M, Frezal L, Jones RT, Chamberlain NL, Lee SF et al.

    Nature 2011;477;7363;203-6

  • Genomic libraries: I. Construction and screening of fosmid genomic libraries.

    Quail MA, Matthews L, Sims S, Lloyd C, Beasley H and Baxter SW

    Methods in molecular biology (Clifton, N.J.) 2011;772;37-58

  • Genomic libraries: II. Subcloning, sequencing, and assembling large-insert genomic DNA clones.

    Quail MA, Matthews L, Sims S, Lloyd C, Beasley H and Baxter SW

    Methods in molecular biology (Clifton, N.J.) 2011;772;59-81

  • Characterization of a hotspot for mimicry: assembly of a butterfly wing transcriptome to genomic sequence at the HmYb/Sb locus.

    Ferguson L, Lee SF, Chamberlain N, Nadeau N, Joron M et al.

    Molecular ecology 2010;19 Suppl 1;240-54

  • The genomic sequence and analysis of the swine major histocompatibility complex.

    Renard C, Hart E, Sehra H, Beasley H, Coggill P et al.

    Genomics 2006;88;1;96-110

  • The DNA sequence and biological annotation of human chromosome 1.

    Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D et al.

    Nature 2006;441;7091;315-21

  • The DNA sequence and analysis of human chromosome 13.

    Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL et al.

    Nature 2004;428;6982;522-8

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