I work in hematopoiesis and hematopoietic malignancies in human cell lines and mouse models. My area of expertise is analysis of high throughput genomics data and large scale data integration primarily ChIP-seq, DNase-seq and RNA-seq.
Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data.
Molecular cancer 2016;15;1;76
Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.
Developmental cell 2016;36;5;572-87
A histidine aspartate ionic lock gates the iron passage in miniferritins from Mycobacterium smegmatis.
The Journal of biological chemistry 2014;289;16;11042-58
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.
The EMBO journal 2012;31;22;4318-33
Insights into the fold organization of TIM barrel from interaction energy based structure networks.
PLoS computational biology 2012;8;5;e1002505
Interaction energy based protein structure networks.
Biophysical journal 2010;99;11;3704-15
Comparative analysis of thermophilic and mesophilic proteins using Protein Energy Networks.
BMC bioinformatics 2010;11 Suppl 1;S49