Dr Gabriel Balmus, DVM | Postdoctoral associate

Balmus, Gabriel

As part of Steve Jackson's laboratory, Gabi is interested in the DNA damage response (DDR) and its connection to inborn disease, cancer and ageing.

1. Gabi is interested in the mechanisms of ageing and their connection to DDR. Together with Dr. Delphine Larrieu in the lab, Gabi is exploring the possibility of ameliorating Hutchinson-Gilford progeria phenotypes.

2. Within the "CRISPR-Cas9 revolution" together with Dr. Josep Forment in the lab, Gabi is exploring the mechanism governing genetic interactions within the DDR, including synthetic lethality and viability, via the use of whole genome CRISPR libraries.

3. Together with Dr. Andrew Blackford in the lab, Gabi is exploring the roles of a newly identified non-homologous end joining factor, PAXX, in physiology and disease.

4. A particular area of interest is the roles of the deubiquitinating enzymes (DUBs) in DDR. To this extent, Gabi is investigating the roles of specific DUBs in physiology and disease.

5. Together with Dr. David Adams's group, Gabi is performing a screen for genes involved in the formation of micronuclei, in vivo markers of genomic instability.

Publications

  • HUS1 regulates in vivo responses to genotoxic chemotherapies.

    Balmus G, Lim PX, Oswald A, Hume KR, Cassano A et al.

    Oncogene 2016;35;5;662-9

  • A high-throughput in vivo micronucleus assay for genome instability screening in mice.

    Balmus G, Karp NA, Ng BL, Jackson SP, Adams DJ and McIntyre RE

    Nature protocols 2015;10;1;205-15

  • Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

    Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR et al.

    Human molecular genetics 2012;21;15;3408-20

  • Cross-species chromosome painting among camel, cattle, pig and human: further insights into the putative Cetartiodactyla ancestral karyotype.

    Balmus G, Trifonov VA, Biltueva LS, O'Brien PC, Alkalaeva ES et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2007;15;4;499-515

  • HUS1 regulates in vivo responses to genotoxic chemotherapies.

    Balmus G, Lim PX, Oswald A, Hume KR, Cassano A et al.

    Oncogene 2016;35;5;662-9

  • A high-throughput in vivo micronucleus assay for genome instability screening in mice.

    Balmus G, Karp NA, Ng BL, Jackson SP, Adams DJ and McIntyre RE

    Nature protocols 2015;10;1;205-15

  • p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression.

    Okayama S, Kopelovich L, Balmus G, Weiss RS, Herbert BS et al.

    The Journal of biological chemistry 2014;289;10;6513-25

  • Genetic screens in mice for genome integrity maintenance and cancer predisposition.

    Balmus G and McIntyre RE

    Current opinion in genetics & development 2014;24;1-7

  • Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

    Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR et al.

    Human molecular genetics 2012;21;15;3408-20

  • The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.

    Daugherity EK, Balmus G, Al Saei A, Moore ES, Abi Abdallah D et al.

    Cell cycle (Georgetown, Tex.) 2012;11;10;1918-28

  • A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.

    Qi Q, Huang W, Bai Y, Balmus G, Weiss RS and August A

    Journal of immunology (Baltimore, Md. : 1950) 2012;188;8;3611-9

  • Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.

    Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A et al.

    PLoS genetics 2011;7;6;e1002094

  • Cross-species chromosome painting among camel, cattle, pig and human: further insights into the putative Cetartiodactyla ancestral karyotype.

    Balmus G, Trifonov VA, Biltueva LS, O'Brien PC, Alkalaeva ES et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2007;15;4;499-515

Career/Research Highlights

Balmus, Gabriel
Gabriel's Timeline
2013

Joined the Jackson Laboratory - Gurdon Institute, University of Cambridge, UK

Postdoctoral associate - Weiss Lab - College of Veterinary Medicine, Cornell University, USA

2012

PhD - Weiss Lab - College of Veterinary Medicine, Cornell University, USA

2007

DVM - Faculty of Veterinary Medicine, Iasi, Romania