David Adams, PhD | Senior Group Leader

David uses DNA sequencing of patients and genetic screens in human cells and mice to identify cancer genes and genetic interactions.

Dr. David Adams and his group study the mechanisms of cancer development, particularly skin cancer (melanoma) and colorectal cancer. They sequence DNA from families with a high incidence of cancer, and also tumours from patients to understand why some people are at greater risk of tumour development and how cancers evolve. The group also performs functional studies in cultured cells and in mice to understand how factors such as DNA mutations and the immune system influence tumour growth.

Publications

  • The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.

    Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG et al.

    Nature 2015;517;7535;489-92

  • BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.

    Perna D, Karreth FA, Rust AG, Perez-Mancera PA, Rashid M et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;6;E536-45

  • Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes.

    Rashid M, Fischer A, Wilson CH, Tiffen J, Rust AG et al.

    The Journal of pathology 2016;238;1;98-108

  • BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib.

    Ranzani M, Alifrangis C, Perna D, Dutton-Regester K, Pritchard A et al.

    Pigment cell & melanoma research 2015;28;1;117-9

  • The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

    Karreth FA, Reschke M, Ruocco A, Ng C, Chapuy B et al.

    Cell 2015;161;2;319-32

  • POT1 loss-of-function variants predispose to familial melanoma.

    Robles-Espinoza CD, Harland M, Ramsay AJ, Aoude LG, Quesada V et al.

    Nature genetics 2014;46;5;478-81

  • Inactivating CUX1 mutations promote tumorigenesis.

    Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C et al.

    Nature genetics 2014;46;1;33-8

  • Cancer gene discovery goes mobile.

    van der Weyden L, Ranzani M and Adams DJ

    Nature genetics 2014;46;9;928-9

  • Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G et al.

    PLoS genetics 2012;8;11;e1003022

  • Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.

    March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J et al.

    Nature genetics 2011;43;12;1202-9

  • Mouse genomic variation and its effect on phenotypes and gene regulation.

    Keane TM, Goodstadt L, Danecek P, White MA, Wong K et al.

    Nature 2011;477;7364;289-94

  • In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.

    Karreth FA, Tay Y, Perna D, Ala U, Tan SM et al.

    Cell 2011;147;2;382-95

  • Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.

    Chen L, Jenjaroenpun P, Pillai AM, Ivshina AV, Ow GS et al.

    Proceedings of the National Academy of Sciences of the United States of America 2017;114;11;E2215-E2224

  • A population-based analysis of germline BAP1 mutations in melanoma.

    O'Shea SJ, Robles-Espinoza CD, McLellan L, Harrigan J, Jacq X et al.

    Human molecular genetics 2017

  • Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

    Weyden LV, Arends MJ, Campbell AD, Bald T, Wardle-Jones H et al.

    Nature 2017

  • The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity.

    Cambridge EL, McIntyre Z, Clare S, Arends MJ, Goulding D et al.

    Experimental hematology 2017;45;64-68.e5

  • Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.

    Müller MF, Zhou Y, Adams DJ and Arends MJ

    The Journal of pathology 2016

  • Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency.

    Kuijpers TW, Tool AT, van der Bijl I, de Boer M, van Houdt M et al.

    The Journal of allergy and clinical immunology 2016

  • Synthetic lethality between PAXX and XLF in mammalian development.

    Balmus G, Barros AC, Wijnhoven PW, Lescale C, Hasse HL et al.

    Genes & development 2016;30;19;2152-2157

  • High-throughput discovery of novel developmental phenotypes.

    Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD et al.

    Nature 2016;537;7621;508-514

  • A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.

    McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N et al.

    G3 (Bethesda, Md.) 2016;6;8;2343-54

  • Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations.

    Doran AG, Wong K, Flint J, Adams DJ, Hunter KW and Keane TM

    Genome biology 2016;17;1;167

  • Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.

    Ahmad I, Mui E, Galbraith L, Patel R, Tan EH et al.

    Proceedings of the National Academy of Sciences of the United States of America 2016;113;29;8290-5

  • Germline MC1R status influences somatic mutation burden in melanoma.

    Robles-Espinoza CD, Roberts ND, Chen S, Leacy FP, Alexandrov LB et al.

    Nature communications 2016;7;12064

  • Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.

    Nicod J, Davies RW, Cai N, Hassett C, Goodstadt L et al.

    Nature genetics 2016

  • BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

    Kemper K, Krijgsman O, Kong X, Cornelissen-Steijger P, Shahrabi A et al.

    Cell reports 2016;16;1;263-77

  • Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole body energy expenditure.

    Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D et al.

    The Journal of pathology 2016

  • Desmoplastic melanoma: C>Ts and NF-κB.

    Rabbie R and Adams DJ

    Pigment cell & melanoma research 2016;29;2;120-1

  • Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes.

    Rashid M, Fischer A, Wilson CH, Tiffen J, Rust AG et al.

    The Journal of pathology 2016;238;1;98-108

  • Cross-species models of human melanoma.

    van der Weyden L, Patton EE, Wood GA, Foote AK, Brenn T et al.

    The Journal of pathology 2016;238;2;152-65

  • Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.

    Espana-Agusti J, Zou X, Wong K, Fu B, Yang F et al.

    PloS one 2016;11;2;e0148055

  • Germline TERT promoter mutations are rare in familial melanoma.

    Harland M, Petljak M, Robles-Espinoza CD, Ding Z, Gruis NA et al.

    Familial cancer 2016;15;1;139-44

  • Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.

    McCreery MQ, Halliwill KD, Chin D, Delrosario R, Hirst G et al.

    Nature medicine 2015;21;12;1514-20

  • A gene expression resource generated by genome-wide lacZ profiling in the mouse.

    Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA et al.

    Disease models & mechanisms 2015;8;11;1467-78

  • The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes.

    Adams DJ, Doran AG, Lilue J and Keane TM

    Mammalian genome : official journal of the International Mammalian Genome Society 2015;26;9-10;403-12

  • A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

    Giotopoulos G, van der Weyden L, Osaki H, Rust AG, Gallipoli P et al.

    The Journal of experimental medicine 2015;212;10;1551-69

  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

    Hrabě de Angelis M, Nicholson G, Selloum M, White JK, Morgan H et al.

    Nature genetics 2015;47;9;969-78

  • Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts.

    Kemper K, Krijgsman O, Cornelissen-Steijger P, Shahrabi A, Weeber F et al.

    EMBO molecular medicine 2015;7;9;1104-18

  • Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.

    van der Weyden L, Giotopoulos G, Wong K, Rust AG, Robles-Espinoza CD et al.

    BMC cancer 2015;15;585

  • Mouse models of colorectal cancer as preclinical models.

    McIntyre RE, Buczacki SJ, Arends MJ and Adams DJ

    BioEssays : news and reviews in molecular, cellular and developmental biology 2015;37;8;909-20

  • PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.

    Dang J, Wei L, de Ridder J, Su X, Rust AG et al.

    Blood 2015;125;23;3609-17

  • Synthetic viability genomic screening defines Sae2 function in DNA repair.

    Puddu F, Oelschlaegel T, Guerini I, Geisler NJ, Niu H et al.

    The EMBO journal 2015;34;11;1509-22

  • The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

    Karreth FA, Reschke M, Ruocco A, Ng C, Chapuy B et al.

    Cell 2015;161;2;319-32

  • CopywriteR: DNA copy number detection from off-target sequence data.

    Kuilman T, Velds A, Kemper K, Ranzani M, Bombardelli L et al.

    Genome biology 2015;16;49

  • BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.

    Perna D, Karreth FA, Rust AG, Perez-Mancera PA, Rashid M et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;6;E536-45

  • Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.

    Aoude LG, Pritchard AL, Robles-Espinoza CD, Wadt K, Harland M et al.

    Journal of the National Cancer Institute 2015;107;2

  • Telomere-regulating genes and the telomere interactome in familial cancers.

    Robles-Espinoza CD, Velasco-Herrera Mdel C, Hayward NK and Adams DJ

    Molecular cancer research : MCR 2015;13;2;211-22

  • Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.

    Takeda H, Wei Z, Koso H, Rust AG, Yew CC et al.

    Nature genetics 2015;47;2;142-50

  • The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.

    Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG et al.

    Nature 2015;517;7535;489-92

  • A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.

    Espana-Agusti J, Tuveson DA, Adams DJ and Matakidou A

    Scientific reports 2015;5;11061

  • The utility of transposon mutagenesis for cancer studies in the era of genome editing.

    DeNicola GM, Karreth FA, Adams DJ and Wong CC

    Genome biology 2015;16;229

  • BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib.

    Ranzani M, Alifrangis C, Perna D, Dutton-Regester K, Pritchard A et al.

    Pigment cell & melanoma research 2015;28;1;117-9

  • Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.

    Salsbury G, Cambridge EL, McIntyre Z, Arends MJ, Karp NA et al.

    Experimental hematology 2014;42;12;1053-8.e1

  • Mutation, clonal fitness and field change in epithelial carcinogenesis.

    Frede J, Adams DJ and Jones PH

    The Journal of pathology 2014;234;3;296-301

  • Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy.

    Weninger WJ, Geyer SH, Martineau A, Galli A, Adams DJ et al.

    Disease models & mechanisms 2014;7;10;1143-52

  • Cancer gene discovery goes mobile.

    van der Weyden L, Ranzani M and Adams DJ

    Nature genetics 2014;46;9;928-9

  • One patient, two lesions, two oncogenic drivers of gastric cancer.

    Alsinet C, Ranzani M and Adams DJ

    Genome biology 2014;15;8;444

  • A strategy to identify dominant point mutant modifiers of a quantitative trait.

    Dove WF, Shedlovsky A, Clipson L, Amos-Landgraf JM, Halberg RB et al.

    G3 (Bethesda, Md.) 2014;4;6;1113-21

  • POT1 loss-of-function variants predispose to familial melanoma.

    Robles-Espinoza CD, Harland M, Ramsay AJ, Aoude LG, Quesada V et al.

    Nature genetics 2014;46;5;478-81

  • Cross-species analysis of mouse and human cancer genomes.

    Robles-Espinoza CD and Adams DJ

    Cold Spring Harbor protocols 2014;2014;4;350-8

  • Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.

    Huser CA, Gilroy KL, de Ridder J, Kilbey A, Borland G et al.

    PLoS genetics 2014;10;2;e1004167

  • Editorial overview: cancer genomics: kill it. Kill it dead.

    Adams D and McDermott U

    Current opinion in genetics & development 2014;24;v-vi

  • Identification of structural variation in mouse genomes.

    Keane TM, Wong K, Adams DJ, Flint J, Reymond A and Yalcin B

    Frontiers in genetics 2014;5;192

  • Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

    Karp NA, Speak AO, White JK, Adams DJ, Hrabé de Angelis M et al.

    PloS one 2014;9;10;e111239

  • Inactivating CUX1 mutations promote tumorigenesis.

    Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C et al.

    Nature genetics 2014;46;1;33-8

  • Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

    Maguire S, Estabel J, Ingham N, Pearson S, Ryder E et al.

    PloS one 2014;9;3;e91807

  • Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.

    Bard-Chapeau EA, Nguyen AT, Rust AG, Sayadi A, Lee P et al.

    Nature genetics 2014;46;1;24-32

  • Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.

    Tachibana-Konwalski K, Godwin J, Borsos M, Rattani A, Adams DJ and Nasmyth K

    Current biology : CB 2013;23;24;2534-9

  • Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.

    Genovesi LA, Ng CG, Davis MJ, Remke M, Taylor MD et al.

    Proceedings of the National Academy of Sciences of the United States of America 2013;110;46;E4325-34

  • Cancer gene discovery: exploiting insertional mutagenesis.

    Ranzani M, Annunziato S, Adams DJ and Montini E

    Molecular cancer research : MCR 2013;11;10;1141-58

  • Cake: a bioinformatics pipeline for the integrated analysis of somatic variants in cancer genomes.

    Rashid M, Robles-Espinoza CD, Rust AG and Adams DJ

    Bioinformatics (Oxford, England) 2013;29;17;2208-10

  • Mutational genomics for cancer pathway discovery

    De Ridder,J., Kool,J, Uren,A.G., Bot,J., De Jong,J. et al.

    Lecture Notes in Computer Science  2013;7986;35-46

  • The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains.

    Takada T, Ebata T, Noguchi H, Keane TM, Adams DJ et al.

    Genome research 2013;23;8;1329-38

  • Cooperativity and rapid evolution of cobound transcription factors in closely related mammals.

    Stefflova K, Thybert D, Wilson MD, Streeter I, Aleksic J et al.

    Cell 2013;154;3;530-40

  • Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.

    Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M et al.

    Cell 2013;154;3;691-703

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.

    Rat Genome Sequencing and Mapping Consortium, Baud A, Hermsen R, Guryev V, Stridh P et al.

    Nature genetics 2013;45;7;767-75

  • Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

    Ryder E, Wong K, Gleeson D, Keane TM, Sethi D et al.

    Genesis (New York, N.Y. : 2000) 2013;51;7;523-8

  • Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.

    Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T et al.

    Glia 2013;61;5;679-93

  • Cancer of mice and men: old twists and new tails.

    van der Weyden L and Adams DJ

    The Journal of pathology 2013;230;1;4-16

  • Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice.

    Mohun T, Adams DJ, Baldock R, Bhattacharya S, Copp AJ et al.

    Disease models & mechanisms 2013;6;3;562-6

  • Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening.

    Adams D, Baldock R, Bhattacharya S, Copp AJ, Dickinson M et al.

    Disease models & mechanisms 2013;6;3;571-9

  • RetroSeq: transposable element discovery from next-generation sequencing data.

    Keane TM, Wong K and Adams DJ

    Bioinformatics (Oxford, England) 2013;29;3;389-90

  • Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

    Klijn C, Koudijs MJ, Kool J, ten Hoeve J, Boer M et al.

    PloS one 2013;8;5;e62113

  • Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents.

    Halligan DL, Kousathanas A, Ness RW, Harr B, Eöry L et al.

    PLoS genetics 2013;9;12;e1003995

  • Go retro and get a GRIP.

    Wong K, Adams DJ and Keane TM

    Genome biology 2013;14;3;108

  • Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.

    Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H et al.

    American journal of human genetics 2012;91;6;998-1010

  • Generation of the Sotos syndrome deletion in mice.

    Migdalska AM, van der Weyden L, Ismail O, Sanger Mouse Genetics Project, Rust AG et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;11-12;749-57

  • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

    Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB et al.

    Nature 2012;491;7424;399-405

  • Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells.

    Koso H, Takeda H, Yew CC, Ward JM, Nariai N et al.

    Proceedings of the National Academy of Sciences of the United States of America 2012;109;44;E2998-3007

  • Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

    Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;600-10

  • Next-generation sequencing of experimental mouse strains.

    Yalcin B, Adams DJ, Flint J and Keane TM

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;490-8

  • Sequencing and characterization of the FVB/NJ mouse genome.

    Wong K, Bumpstead S, Van Der Weyden L, Reinholdt LG, Wilming LG et al.

    Genome biology 2012;13;8;R72

  • Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

    van der Weyden L, Papaspyropoulos A, Poulogiannis G, Rust AG, Rashid M et al.

    Cancer research 2012;72;15;3817-27

  • The genomic landscape shaped by selection on transposable elements across 18 mouse strains.

    Nellåker C, Keane TM, Yalcin B, Wong K, Agam A et al.

    Genome biology 2012;13;6;R45

  • Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1.

    van der Weyden L, Arends MJ, Rust AG, Poulogiannis G, McIntyre RE and Adams DJ

    Molecular cancer 2012;11;29

  • The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.

    Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A et al.

    Nature 2012;486;7402;266-70

  • A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.

    Bagley BN, Keane TM, Maklakova VI, Marshall JG, Lester RA et al.

    PLoS genetics 2012;8;11;e1003034

  • Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G et al.

    PLoS genetics 2012;8;11;e1003022

  • Sequence-based characterization of structural variation in the mouse genome.

    Yalcin B, Wong K, Agam A, Goodson M, Keane TM et al.

    Nature 2011;477;7364;326-9

  • Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

    Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PH et al.

    Nature genetics 2011;43;2;147-52

  • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

    Varela I, Tarpey P, Raine K, Huang D, Ong CK et al.

    Nature 2011;469;7331;539-42

  • Genomics in 2011: challenges and opportunities.

    Adams DJ, Berger B, Harismendy O, Huttenhower C, Liu XS et al.

    Genome biology 2011;12;12;137

  • Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.

    Tachibana-Konwalski K, Godwin J, van der Weyden L, Champion L, Kudo NR et al.

    Genes & development 2010;24;22;2505-16

  • Slingshot: a PiggyBac based transposon system for tamoxifen-inducible 'self-inactivating' insertional mutagenesis.

    Kong J, Wang F, Brenton JD and Adams DJ

    Nucleic acids research 2010;38;18;e173

  • Commercially available outbred mice for genome-wide association studies.

    Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J et al.

    PLoS genetics 2010;6;9;e1001085

  • PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

    Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH et al.

    Proceedings of the National Academy of Sciences of the United States of America 2010;107;34;15145-50

  • The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.

    Wilson CH, McIntyre RE, Arends MJ and Adams DJ

    Oncogene 2010;29;32;4567-75

  • Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens.

    Wood HM, Belvedere O, Conway C, Daly C, Chalkley R et al.

    Nucleic acids research 2010;38;14;e151

  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.

    Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF et al.

    PLoS genetics 2010;6;7;e1001023

  • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.

    Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J et al.

    Nature structural & molecular biology 2010;17;6;688-95

  • Copy number variant detection in inbred strains from short read sequence data.

    Simpson JT, McIntyre RE, Adams DJ and Durbin R

    Bioinformatics (Oxford, England) 2010;26;4;565-7

  • Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes.

    Steward CA, Humphray S, Plumb B, Jones MC, Quail MA et al.

    Genomics 2010;95;2;105-10

  • Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.

    Mattison J, Kool J, Uren AG, de Ridder J, Wessels L et al.

    Cancer research 2010;70;3;883-95

  • Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.

    Kool J, Uren AG, Martins CP, Sie D, de Ridder J et al.

    Cancer research 2010;70;2;520-31

  • A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors.

    Evers B, Schut E, van der Burg E, Braumuller TM, Egan DA et al.

    Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16;1;99-108

  • Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

    Dietrich MF, van der Weyden L, Prosser HM, Bradley A, Herz J and Adams DJ

    PloS one 2010;5;4;e9960

  • Identification of networks of co-occurring, tumor-related DNA copy number changes using a genome-wide scoring approach.

    Klijn C, Bot J, Adams DJ, Reinders M, Wessels L and Jonkers J

    PLoS computational biology 2010;6;1;e1000631

  • The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

    Brass AL, Huang IC, Benita Y, John SP, Krishnan MN et al.

    Cell 2009;139;7;1243-54

  • Cancer gene discovery in mouse and man.

    Mattison J, van der Weyden L, Hubbard T and Adams DJ

    Biochimica et biophysica acta 2009;1796;2;140-61

  • Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.

    Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ et al.

    PLoS genetics 2009;5;12;e1000759

  • Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.

    Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K et al.

    Cancer research 2009;69;21;8429-37

  • Next-generation sequencing of vertebrate experimental organisms.

    Turner DJ, Keane TM, Sudbery I and Adams DJ

    Mammalian genome : official journal of the International Mammalian Genome Society 2009;20;6;327-38

  • Megaoesophagus in Rassf1a-null mice.

    van der Weyden L, Happerfield L, Arends MJ and Adams DJ

    International journal of experimental pathology 2009;90;2;101-8

  • A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.

    Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH et al.

    Nature protocols 2009;4;5;789-98

  • iMapper: a web application for the automated analysis and mapping of insertional mutagenesis sequence data against Ensembl genomes.

    Kong J, Zhu F, Stalker J and Adams DJ

    Bioinformatics (Oxford, England) 2008;24;24;2923-5

  • Contemporary approaches for modifying the mouse genome.

    Adams DJ and van der Weyden L

    Physiological genomics 2008;34;3;225-38

  • Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.

    Lange UC, Adams DJ, Lee C, Barton S, Schneider R et al.

    Molecular and cellular biology 2008;28;15;4688-96

  • Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.

    van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G et al.

    Oncogene 2008;27;32;4503-8

  • Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

    Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J et al.

    Cell 2008;133;4;727-41

  • Renin enhancer is crucial for full response in Renin expression to an in vivo stimulus.

    Markus MA, Goy C, Adams DJ, Lovicu FJ and Morris BJ

    Hypertension (Dallas, Tex. : 1979) 2007;50;5;933-8

  • The Ras-association domain family (RASSF) members and their role in human tumourigenesis.

    van der Weyden L and Adams DJ

    Biochimica et biophysica acta 2007;1776;1;58-85

  • Renin enhancer is critical for control of renin gene expression and cardiovascular function.

    Adams DJ, Head GA, Markus MA, Lovicu FJ, van der Weyden L et al.

    The Journal of biological chemistry 2006;281;42;31753-61

  • Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.

    van der Weyden L, Wei L, Luo J, Yang X, Birk DE et al.

    The American journal of pathology 2006;169;2;515-27

  • TranscriptSNPView: a genome-wide catalog of mouse coding variation.

    Cunningham F, Rios D, Griffiths M, Smith J, Ning Z et al.

    Nature genetics 2006;38;8;853

  • Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.

    Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M et al.

    Genes & development 2006;20;14;1880-4

  • Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.

    van der Weyden L, Arends MJ, Chausiaux OE, Ellis PJ, Lange UC et al.

    Molecular and cellular biology 2006;26;9;3595-609

  • DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

    Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J et al.

    Nature 2006;440;7087;1045-9

  • A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction.

    Adams DJ, Quail MA, Cox T, van der Weyden L, Gorick BD et al.

    Genomics 2005;86;6;753-8

  • The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis.

    van der Weyden L, Tachibana KK, Gonzalez MA, Adams DJ, Ng BL et al.

    Molecular and cellular biology 2005;25;18;8356-67

  • Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector.

    van der Weyden L, Adams DJ, Harris LW, Tannahill D, Arends MJ and Bradley A

    Genesis (New York, N.Y. : 2000) 2005;41;4;171-8

  • BRCTx is a novel, highly conserved RAD18-interacting protein.

    Adams DJ, van der Weyden L, Gergely FV, Arends MJ, Ng BL et al.

    Molecular and cellular biology 2005;25;2;779-88

  • Mutagenic insertion and chromosome engineering resource (MICER).

    Adams DJ, Biggs PJ, Cox T, Davies R, van der Weyden L et al.

    Nature genetics 2004;36;8;867-71

  • Tools for targeted manipulation of the mouse genome.

    van der Weyden L, Adams DJ and Bradley A

    Physiological genomics 2002;11;3;133-64

  • Induced mitotic recombination: a switch in time.

    Adams DJ and Bradley A

    Nature genetics 2002;30;1;6-7

Career/Research Highlights

Adams, David
David's Timeline
2012

Senior Group Leader

2006

Group Leader

2001

Join the Sanger Institute

PhD University of Sydney