News Archive

News Archive

Landmark project shows heart disease and rheumatoid arthritis risk raised by genetic changes in blood cells

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Landmark project shows heart disease and rheumatoid arthritis risk raised by genetic changes in blood cells

As part of BLUEPRINT, Wellcome Trust Sanger Institute led two of the six papers published in the journal Cell

The papers reveal how variation in blood cells’ characteristics and numbers can affect a person’s risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, coeliac disease and type 1 diabetes.

Multi-drug resistant infection spreading globally among cystic fibrosis patients

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Multi-drug resistant infection spreading globally among cystic fibrosis patients

Study reveals challenge to infection control practices in hospitals

A multi-drug resistant infection that can cause life-threatening illness in people with cystic fibrosis (CF) and can spread from patient to patient has spread globally and is becoming increasingly virulent, according to new research published today in the journal Science.

Newton's apple seeds to grow on Wellcome Genome Campus

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Newton's apple seeds to grow on Wellcome Genome Campus

Wellcome Genome Campus Connecting Science celebrate International Science Centre Day

Wellcome Genome Campus Connecting Science applied for the seeds so that they can grow their own Newton's Apple Tree under which they can share the Campus' science and stories with school children and the public.

Genetic marker found for resistance to malaria treatment in Cambodia

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Genetic marker found for resistance to malaria treatment in Cambodia

Resistance to the key anti-malarial drug piperaquine has recently emerged in Cambodia, this research will help health officials to monitor its spread

Reporting in Lancet Infectious Diseases, scientists at the Wellcome Trust Sanger Institute and their collaborators have discovered genetic markers in malaria parasites linked with resistance to piperaquine.

Smoking a pack a day for a year causes 150 mutations in lung cells

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Smoking a pack a day for a year causes 150 mutations in lung cells

Genetic damage caused by smoking measured in different organs of the body

Scientists have measured the catastrophic genetic damage caused by smoking in different organs of the body and identified several different mechanisms by which tobacco smoking causes mutations in DNA. Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory and their collaborators found smokers accumulated an average of 150 extra mutations in every lung cell for each year of smoking one packet of cigarettes a day.

Ancient interbreeding between chimpanzees and bonobos revealed

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Ancient interbreeding between chimpanzees and bonobos revealed

Genome study creates new conservation opportunities

Genome sequencing has revealed ancient gene mixing between chimpanzees and bonobos, mankind’s closest relatives, showing parallels with Neanderthal mixing in human ancestry. The study showed that 1% of chimpanzee genomes are derived from bonobos. It also found that genomics could aid chimpanzee conservation, by helping reveal the country of origin of individual chimpanzees.

Sanger Institute Researcher Sam Behjati given the inaugural St. Baldrick’s Foundation Robert J Arceci International Award

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Sanger Institute Researcher Sam Behjati given the inaugural St. Baldrick’s Foundation Robert J Arceci International Award

The revolutionary award will allow Dr Behjati to focus on finding treatments for childhood cancers without typical research restrictions

The Robert J. Arceci Innovation Award gives Dr Behjati the ability to pursue whatever leads he uncovers, and to focus on discovery and making a difference for patients. Dr Behjati plans to continue his work on understanding the cancer genome – the genetic changes that give rise to childhood cancer. He hopes to explore single cell sequencing technologies to understand where cancer cells come from and what the alternative fate of cancer cells might be. By understanding this path, Dr Behjati believes it might be possible to redirect a cancer cell to become something less harmful.

Vulnerabilities of leukaemia cells revealed using genome editing technique

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Vulnerabilities of leukaemia cells revealed using genome editing technique

Researchers have uncovered approximately 500 genes that are essential for cancer cell survival, including more than 200 for which drugs could be designed.

Researchers from the Wellcome Trust Sanger Institute and their collaborators have adapted a CRISPR gene editing technique and used it to find new therapeutic targets for acute myeloid leukaemia (AML).

International Human Cell Atlas Initiative

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International Human Cell Atlas Initiative

An ambitious global initiative to create a Human Cell Atlas - a description of every cell in the human body as a reference map to accelerate progress in biomedical science - was discussed at an International meeting in London on 13-14 October. Ultimately, the Human Cell Atlas would revolutionise how doctors and researchers understand, diagnose and treat disease.

The Human Cell Atlas initiative seeks to bring in a new era of cellular understanding, founded on the discovery of new cell types, and investigating how these cells change across time, during development and disease, to gain a better understanding of biology.

New drug target for asthma

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New drug target for asthma

PD-1 marker found in immune cells that can trigger asthma

A new therapeutic target for inflammatory diseases such as asthma and autoimmune disorders has been identified by scientists at the Wellcome Trust Sanger Institute. Published in Nature, the researchers found that the PD-1 protein is a marker for developing Innate Lymphoid Cells that can trigger asthma. PD-1 is a drug target for some cancers. These findings show that drugs that target PD-1 could also be developed for treating asthma and other inflammatory diseases.

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