News Archive

News Archive

Launch of new European Stem Cell Bank

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Launch of new European Stem Cell Bank

Sanger Institute's stem cells pipeline contributes HiPSCi cell lines to international resource.

EBiSC, the European Bank for induced pluripotent Stem Cells, has launched its on-line catalogue of induced Pluripotent Stem Cells (iPSCs) for academic and commercial use in modelling disease and for other forms of pre-clinical research. ( https://cells.ebisc.org)

Genomes of chimpanzee parasite species reveal evolution of human malaria

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Genomes of chimpanzee parasite species reveal evolution of human malaria

Whole-genome sequencing and analysis has been used to explore and understand the origins of human malarial disease.

The chimpanzee parasite genomes contain a goldmine of information about the evolutionary origins of the malaria parasites infecting humans. One of the first things to emerge from genome-wide analyses was that the parasites represent distinct, non-interbreeding species that are approximately 10 times more genetically diverse than human parasites.

Black fever beats drugs by adding just two DNA bases to its genome

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Black fever beats drugs by adding just two DNA bases to its genome

For drug resistance, sometimes it just takes two (extra DNA base pairs)

In eLife, Wellcome Trust Sanger Institute scientists identify how certain strains of the fatal neglected tropical parasite Leishmania donovani have become immune to drug treatment. The addition of just two bases of DNA to the gene LdAQP1 stops the organism from absorbing antimonial drugs.

Genomic study of epidemic dysentery reveals how Europe exported a scourge worldwide

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Genomic study of epidemic dysentery reveals how Europe exported a scourge worldwide

Largest genetic study of the bacterium responsible for epidemic dysentery has revealed that the Shigella dysenteriae pathogen, which remains a real scourge in Africa and Asia, probably originated in Europe.

Research carried out by scientists from the Wellcome Trust Sanger Institute and Institut Pasteur in Paris, and published in the journal Nature Microbiology ,  charts the development of the S. dysenteriae's resistance to antibiotics.

Strongest single gene conclusively implicated in schizophrenia

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Strongest single gene conclusively implicated in schizophrenia

Single-letter changes to the DNA code of one gene have been shown to have a substantial effect on the risk of schizophrenia.

An international consortium of researchers, led by a team at the Wellcome Trust Sanger Institute, has discovered conclusive evidence for the involvement of a gene called SETD1A in schizophrenia. Damaging changes to this gene, which occur rarely, increase the risk of schizophrenia 35-fold and also increase risk for a wide range of neurodevelopmental disorders.

Politicians want to make the most of personalised medicine for the NHS

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Politicians want to make the most of personalised medicine for the NHS

More than one hundred stakeholders will join parliamentarians to discuss the nature of personalised medicine and implications for the NHS.

The new All-Party Parliamentary Group (APPG) on Personalised Medicine will hold its official launch event in the House of Commons tomorrow. The Group aims to help the NHS and patients make best use of the increasing availability of cutting-edge technologies to provide more personalised health and care.

Immunology meets single-cell sequencing

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Immunology meets single-cell sequencing

A new computational approach in single-cell genomics reveals how different types of T cells detect, destroy and remember invaders.

Research from the Single-Cell Genomics Centre on the Wellcome Genome Campus could change the way we look at gene expression and immune response. Published in Nature Methods, the new method, TraCeR, provides a powerful tool for research into immune response, vaccination, cancer and autoimmunity.

Leading the way for gender equality

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Leading the way for gender equality

Sumana Sharma of the Wellcome Trust Sanger Institute and Robert Petryszak of the European Bioinformatics Institute (EMBL-EBI) have been recognised for their work to promote gender equality on the Wellcome Genome Campus

Mike Stratton, Ewan Birney and Rolf Apweiler today (8 March) acknowledged the contribution of two staff members to promoting gender equality in the life sciences, bestowing the second annual Sex in Science Best Practice Award on the Wellcome Genome Campus.

Genetic study reveals 50 thousand years of independent history of Aboriginal Australian people

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Genetic study reveals 50 thousand years of independent history of Aboriginal Australian people

Researchers worked with Aboriginal Australian communities to explore heritage

The first complete sequences of the Y chromosomes of Aboriginal Australian men have revealed a deep indigenous genetic history tracing all the way back to the initial settlement of the continent 50 thousand years ago, according to a study published in the journal Current Biology.

Casting light on the neglected tropical disease Trachoma

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Casting light on the neglected tropical disease Trachoma

Genomic sequencing reveals link between STIs and leading cause of infectious blindness

For the first time, genome sequencing has been carried out on Chlamydia trachomatis (C. trachomatis), a bacteria responsible for the disease Trachoma - the world’s leading infectious cause of blindness, according to a study in Nature Communications.Researchers at the Wellcome Trust Sanger Institute and Menzies School of Health Research, Australia have discovered that genes can move from chlamydia strains in the eye to sexually transmitted strains of chlamydia, allowing them to then infect the eye and cause Trachoma – a neglected tropical disease.

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