22 Mar 2016
Whole-genome sequencing and analysis has been used to explore and understand the origins of human malarial disease.
The chimpanzee parasite genomes contain a goldmine of information about the evolutionary origins of the malaria parasites infecting humans. One of the first things to emerge from genome-wide analyses was that the parasites represent distinct, non-interbreeding species that are approximately 10 times more genetically diverse than human parasites.
21 Mar 2016
Largest genetic study of the bacterium responsible for epidemic dysentery has revealed that the Shigella dysenteriae pathogen, which remains a real scourge in Africa and Asia, probably originated in Europe.
Research carried out by scientists from the Wellcome Trust Sanger Institute and Institut Pasteur in Paris, and published in the journal Nature Microbiology , charts the development of the S. dysenteriae's resistance to antibiotics.
14 Mar 2016
More than one hundred stakeholders will join parliamentarians to discuss the nature of personalised medicine and implications for the NHS.
The new All-Party Parliamentary Group (APPG) on Personalised Medicine will hold its official launch event in the House of Commons tomorrow. The Group aims to help the NHS and patients make best use of the increasing availability of cutting-edge technologies to provide more personalised health and care.
14 Mar 2016
Single-letter changes to the DNA code of one gene have been shown to have a substantial effect on the risk of schizophrenia.
An international consortium of researchers, led by a team at the Wellcome Trust Sanger Institute, has discovered conclusive evidence for the involvement of a gene called SETD1A in schizophrenia. Damaging changes to this gene, which occur rarely, increase the risk of schizophrenia 35-fold and also increase risk for a wide range of neurodevelopmental disorders.
8 Mar 2016
Sumana Sharma of the Wellcome Trust Sanger Institute and Robert Petryszak of the European Bioinformatics Institute (EMBL-EBI) have been recognised for their work to promote gender equality on the Wellcome Genome Campus
Mike Stratton, Ewan Birney and Rolf Apweiler today (8 March) acknowledged the contribution of two staff members to promoting gender equality in the life sciences, bestowing the second annual Sex in Science Best Practice Award on the Wellcome Genome Campus.
7 Mar 2016
A new computational approach in single-cell genomics reveals how different types of T cells detect, destroy and remember invaders.
Research from the Single-Cell Genomics Centre on the Wellcome Genome Campus could change the way we look at gene expression and immune response. Published in Nature Methods, the new method, TraCeR, provides a powerful tool for research into immune response, vaccination, cancer and autoimmunity.
25 Feb 2016
Genomic sequencing reveals link between STIs and leading cause of infectious blindness
For the first time, genome sequencing has been carried out on Chlamydia trachomatis (C. trachomatis), a bacteria responsible for the disease Trachoma - the world’s leading infectious cause of blindness, according to a study in Nature Communications.Researchers at the Wellcome Trust Sanger Institute and Menzies School of Health Research, Australia have discovered that genes can move from chlamydia strains in the eye to sexually transmitted strains of chlamydia, allowing them to then infect the eye and cause Trachoma – a neglected tropical disease.
25 Feb 2016
Researchers worked with Aboriginal Australian communities to explore heritage
The first complete sequences of the Y chromosomes of Aboriginal Australian men have revealed a deep indigenous genetic history tracing all the way back to the initial settlement of the continent 50 thousand years ago, according to a study published in the journal Current Biology.
16 Feb 2016
The bilharzia-causing parasite, Schistosoma mansoni, first infected humans as they fished in lakes in East Africa and was spread, first to West Africa and then to the New World, by slave traders in 16th-19th Centuries, genomics reveals
Exploring the full DNA sequences of Schistosoma mansoni parasites from Africa and the French Caribbean has allowed scientists to map the origin of the human-infecting blood fluke, trace its historic transmission and identify the secrets of its success. The findings show how the global slave trade transported the disease from Senegal and Cameroon to Guadeloupe. Further genomic comparison with a closely related schistosome species that infects rodents has revealed how the parasite has adapted to infecting human beings.
8 Feb 2016
The Centre for Therapeutic Target Validation welcomes new member Biogen, expanding its efforts to accelerate drug discovery research
Biogen has joined the Centre for Therapeutic Target Validation (CTTV), the pioneering public-private collaboration to improve the success rate for discovering new medicines. Originally formed by GSK, the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI), the CTTV fosters interactions between academic and industry members to select and validate novel targets in drug development.