News Archive

News Archive

Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type

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Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type

Two new methods will allow researchers world-wide to rapidly and accurately explore the changing role of genes as the cells develop into tissues such as liver, skin or heart, and discover how this contributes to health and disease.

Wellcome Trust Sanger Institute and University of Cambridge researchers have created sOPTiKO, a more efficient and controllable CRISPR genome editing platform. Today (29 November), in the journal Development, they describe how the freely available single-step system works in every cell in the body and at every stage of development. This new approach will aid researchers in developmental biology, tissue regeneration and cancer.

Sanger spin-out secures $100 million

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Sanger spin-out secures $100 million

Company founded on Institute technology goes from strength to strength.

Kymab is a company founded on genetic technologies developed at the Wellcome Trust Sanger Institute by Professor Allan Bradley. Its focus is discovering, developing and delivering new monoclonal antibody medicines to treat a variety of diseases.

River blindness worm’s genome reveals unique fatal flaws

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River blindness worm’s genome reveals unique fatal flaws

In Nature Microbiology, Wellcome Trust Sanger Institute researchers revealed the whole genome of Onchocerca volvulus, and within it key differences to its evolutionary partner in crime

River blindness is a common chronic infectious neglected disease that blights many communities near water in remote areas of the Amazon basin in South America and in Africa. It is caused by the worm Onchocerca volvulus, whose larvae migrate through the body, including into the eyes of infected people, making them blind. The parasite is a major socioeconomic issue in the villages and families it affects because sufferers are no longer able to work. In addition other family members, often children, have to give up their studies or work to care for them, further depriving the family of income or future development.

Prime Minister opened £42M Biodata Innovation Centre and new Sequencing Facility

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Prime Minister opened £42M Biodata Innovation Centre and new Sequencing Facility

The UK Prime Minister Rt Hon Theresa May today (21 November) joined key stakeholders from across the life sciences sector to open the Wellcome Trust Sanger Institute’s new Bridget Ogilvie Building and the Biodata Innovation Centre at the Wellcome Genome Campus in Cambridge.

Together these new buildings will house one of the world’s most advanced gene sequencing facilities and a unique innovation space for global genomics and biodata businesses. These buildings will be home to a powerful collaboration between academia, businesses large and small, charities and Government.

Landmark project shows heart disease and rheumatoid arthritis risk raised by genetic changes in blood cells

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Landmark project shows heart disease and rheumatoid arthritis risk raised by genetic changes in blood cells

As part of BLUEPRINT, Wellcome Trust Sanger Institute led two of the six papers published in the journal Cell

The papers reveal how variation in blood cells’ characteristics and numbers can affect a person’s risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, coeliac disease and type 1 diabetes.

Multi-drug resistant infection spreading globally among cystic fibrosis patients

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Multi-drug resistant infection spreading globally among cystic fibrosis patients

Study reveals challenge to infection control practices in hospitals

A multi-drug resistant infection that can cause life-threatening illness in people with cystic fibrosis (CF) and can spread from patient to patient has spread globally and is becoming increasingly virulent, according to new research published today in the journal Science.

Newton's apple seeds to grow on Wellcome Genome Campus

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Newton's apple seeds to grow on Wellcome Genome Campus

Wellcome Genome Campus Connecting Science celebrate International Science Centre Day

Wellcome Genome Campus Connecting Science applied for the seeds so that they can grow their own Newton's Apple Tree under which they can share the Campus' science and stories with school children and the public.

Genetic marker found for resistance to malaria treatment in Cambodia

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Genetic marker found for resistance to malaria treatment in Cambodia

Resistance to the key anti-malarial drug piperaquine has recently emerged in Cambodia, this research will help health officials to monitor its spread

Reporting in Lancet Infectious Diseases, scientists at the Wellcome Trust Sanger Institute and their collaborators have discovered genetic markers in malaria parasites linked with resistance to piperaquine.

Smoking a pack a day for a year causes 150 mutations in lung cells

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Smoking a pack a day for a year causes 150 mutations in lung cells

Genetic damage caused by smoking measured in different organs of the body

Scientists have measured the catastrophic genetic damage caused by smoking in different organs of the body and identified several different mechanisms by which tobacco smoking causes mutations in DNA. Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory and their collaborators found smokers accumulated an average of 150 extra mutations in every lung cell for each year of smoking one packet of cigarettes a day.

Ancient interbreeding between chimpanzees and bonobos revealed

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Ancient interbreeding between chimpanzees and bonobos revealed

Genome study creates new conservation opportunities

Genome sequencing has revealed ancient gene mixing between chimpanzees and bonobos, mankind’s closest relatives, showing parallels with Neanderthal mixing in human ancestry. The study showed that 1% of chimpanzee genomes are derived from bonobos. It also found that genomics could aid chimpanzee conservation, by helping reveal the country of origin of individual chimpanzees. 

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