12 Sep 2016

Two characteristic patterns of DNA damage found

For the first time, researchers from the Wellcome Trust Sanger Institute and their collaborators have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionising radiation. These fingerprint patterns may now enable doctors to identify which tumours have been caused by radiation, and investigate if they should be treated differently.

22 Aug 2016

Two novel African types differ genetically to Western Salmonella Enteritidis

Salmonella Enteritidis is a major cause of blood poisoning and death in Africa and food poisoning in the Western World. The first global-scale genetic study of has discovered that there are in fact three separate types. Two novel African types look the same, but are genetically different from the common Western type.

22 Aug 2016

Oesophageal cancers driven by 'marginal gain' rather than speed

New study finds that unexpectedly, oesophageal cancer cells do not divide faster than their normal neighbours. But unlike normal cells, the tumour cells produce slightly more dividing daughter cells than non-dividing ones, forming a tumour.

1 Aug 2016

The international study sequenced and analysed the protein-coding segments of the genome of 1,900 congenital heart disease patients and their parents

In one of the largest international genetic studies of congenital heart disease (CHD), researchers have discovered gene mutations linked to three new rare congenital heart disorders. Published in Nature Genetics today (1 August), the researchers also found the first clear evidence of genetic differences between two forms of the disease, and that one form can be traced back to healthy parents.

21 Jul 2016

Study explains genetic effect on cognition

Researchers have found a gene responsible for an intellectual disability disorder and proven how it works. Published in the American Journal of Human Genetics, the study details the role of a gene called BCL11A in a new intellectual disability syndrome.

12 Jul 2016

The burden of mutations is comparable to an extra 21 years of sun exposure

Researchers have proved that gene variants associated with red hair, pale skin and freckles are linked to a higher number of genetic mutations in skin cancers. The burden of mutations associated with these variants is comparable to an extra 21 years of sun exposure in people without this variant. 

11 Jul 2016

Human Cancer Models Initiative (HCMI) will create globally accessible bank of around 1,000 cancer cell models.

An international project to develop a large, globally accessible, bank of new cancer cell culture models for the research community has been launched. The Human Cancer Models Initiative (HCMI) will bring together expertise from around the world to make around 1,000 cancer cell models.

11 Jul 2016

Head of the Cellular Genetics Programme at the Wellcome Trust Sanger Institute is honoured for her work in computational biology and bioinformatics

Dr Sarah Teichmann, has been honoured with a Fellowship by the International Society for Computational Biology (ISCB) in recognition of her exceptional contributions to the fields of computational biology and bioinformatics. As part of the award, the head of the Cellular Generation Programme and group leader at the Wellcome Trust Sanger Institute and EMBL-European Bioinformatics Institute (EMBL-EBI) will give a keynote talk on "Understanding Cellular Heterogeneity" at the Intelligent Systems for Molecular Biology conference today (Monday 11 July) in Orlando. 

7 Jul 2016

Large-scale study could increase success rate of developing personalised cancer treatments

Research published in Cell has shown that patient-derived cancer cell lines harbour most of the same genetic changes found in patients’ tumours, and could be used to learn how tumours are likely to respond to new drugs, increasing the success rate for developing new personalised cancer treatments.

6 Jul 2016

A new atlas of gene expression during the earliest stages of life boosts studies of development

In the first genome-scale experiment of its kind, researchers have gained new insights into how a mouse embryo first begins to transform from a ball of unfocussed cells into a small, structured entity. Published on 6 July in Nature, the single-cell genomics study was led by the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust–MRC Cambridge Stem Cell Institute.