News Archive

News Archive

Sanger scientists win £20 million ‘Grand Challenge’ funding from Cancer Research UK

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Sanger scientists win £20 million ‘Grand Challenge’ funding from Cancer Research UK

Professor Sir Mike Stratton will lead an international team to help transform our understanding of what causes cancer

The first Cancer Research UK Grand Challenge Project seeks to fill in the missing gaps to identify unknown cancer-causing factors and reveal how they lead to cancer. To do this 5,000 pancreatic, kidney, oesophageal and bowel cancer patients, from five continents will be studied and compared.

Malaria vaccine target’s invasion partner uncovered

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Malaria vaccine target’s invasion partner uncovered

This could help develop a more effective malaria vaccine

Researchers discover how a promising malarial vaccine target - the protein RH5 - uses a previously mysterious protein P113 to create a bridge between the parasite and red blood cell.

Genes linked to malaria parasites’ ability to persist in the body

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Genes linked to malaria parasites’ ability to persist in the body

The ability of malaria parasites to persist in the body for years is linked to the expression of a set of genes from the pir gene family

Mouse study shows that as few as 1 in 10 of the parasites that initially appear in the blood express this set of pir genes. But almost all the parasites found persisting in the body at later times express the genes. If the biological mechanisms involved can be targeted, long-lasting persistent malaria infection could be prevented, and prevent ongoing transmission.

Largest genetic study of inflammatory bowel disease provides clues on new drug targets

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Largest genetic study of inflammatory bowel disease provides clues on new drug targets

Genetic variant identified that doubles an individual’s risk of developing ulcerative colitis

Researchers have identified ADCY7, a genetic variant that heightens the risk of developing ulcerative colitis, one of the subtypes of a chronic disorder known as Inflammatory Bowel Disease (IBD). They also uncover a further 25 novel genetic associations to IBD risk.

Genome secrets of elusive human malaria species revealed

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Genome secrets of elusive human malaria species revealed

Improved surveillance and diagnosis of rarer malaria parasites possible

The genomes of the two least common species of human malaria parasites are revealed today (25 January 2017) in Nature by a team of scientists from the Wellcome Trust Sanger Institute and their international collaborators. These sequences will enable improved surveillance and diagnosis of these rarer parasites that still cause more than 10 million malaria cases every year.

Genetic study identifies 14 new developmental disorders in children

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Genetic study identifies 14 new developmental disorders in children

Study shows 400,000 children with developmental disorders born each year globally

The largest-ever genetic study of children with previously undiagnosed rare developmental disorders has discovered 14 new developmental disorders. Published today (25 January 2017) in Nature, the research led by scientists at the Wellcome Trust Sanger Institute also provided diagnoses of rare conditions for over a thousand children and their families. These diagnoses allow families with the same genetic conditions to connect and access support, and help inform better clinical management.

Study reveals new genetic mechanism driving breast cancer

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Study reveals new genetic mechanism driving breast cancer

This new mechanism found in 33 mutation hotspots in the genome.

Researchers at the Wellcome Trust Sanger Institute have discovered ‘hotspots’ of mutations in breast cancer genomes, where mutations thought to be inactive ‘passengers’ in the genome have now been shown to possibly drive further cancerous changes.

Sarah Teichmann given Helmholtz International Fellow Award

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Sarah Teichmann given Helmholtz International Fellow Award

Head of Cellular Genetics recognised with 20,000 Euros to further her research and an invitation to a research stay at Helmholtz Zentrum München (the German Research Centre for Environmental Health).

Dr Sarah Teichmann is one of five scientists to receive this year's Helmholtz International Fellow Award, and the only researcher from the medical sector to be honoured. The awards ceremony is scheduled for the 5 May 2017 at the Helmholtz Campus in Neuherberg near Munich.

Best treatment option written in cancer’s genetic script

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Best treatment option written in cancer’s genetic script

Acute myeloid leukaemia study finds personalised therapy is possible

An international collaboration led by clinical researchers at the Wellcome Trust Sanger Institute has shown proof-of-concept that truly personalised therapy will be possible in the future for people with cancer. Details of how a knowledge bank could be used to find the best treatment option for people with acute myeloid leukaemia (AML) are published today (16 January 2017) in Nature Genetics.

New genes identified that regulate the spread of cancers

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New genes identified that regulate the spread of cancers

Study reveals Spns2 gene as a new drug target

Research led by the Wellcome Trust Sanger Institute has discovered a new biological target for drugs to reduce the spread of tumours in cancer patients. Published in Nature today (11 January 2017), the study with genetically modified mice found 23 genes that are involved in regulating the spread of cancers. The researchers showed that targeting one of these genes – Spns2 – led to a three-quarters reduction in tumour spread.

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